First case of SARS-COV-2 sequencing in cerebrospinal fluid of a patient with suspected demyelinating disease

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art_DOMINGUES_First_case_of_SARSCOV2_sequencing_in_cerebrospinal_fluid_2020.PDF.pdf (628.06 KB)
Citações na Scopus
105
Tipo de produção
article
Data de publicação
2020
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER HEIDELBERG
Autores
DOMINGUES, Renan Barros
LEITE, Fernando Brunale Vilela de Moura
SALARINI, Diego Zanotti
SANTOS, Daniel Wagner
Citação
JOURNAL OF NEUROLOGY, v.267, n.11, p.3154-3156, 2020
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The association between coronaviruses and central nervous system (CNS) demyelinating lesions has been previously shown. However, no case has been described of an association between the novel coronavirus (SARS-COV-2) and CNS demyelinating disease so far. SARS-COV-2 was previously detected in cerebrospinal fluid (CSF) sample of a patient with encephalitis. However, the virus identity was not confirmed by deep sequencing of SARS-COV-2 detected in the CSF. Here, we report a case of a patient with mild respiratory symptoms and neurological manifestations compatible with clinically isolated syndrome. The viral genome of SARS-COV-2 was detected and sequenced in CSF with 99.74-100% similarity between the patient virus and worldwide sequences. This report suggests a possible association of SARS-COV-2 infection with neurological symptoms of demyelinating disease, even in the absence of relevant upper respiratory tract infection signs.
Palavras-chave
COVID-19, SARS-COV-2, Clinically isolated syndrome, Cerebrospinal fluid
URI
https://observatorio.fm.usp.br/handle/OPI/38360
Referências
  1. Arbour N, 1999, J VIROL, V73, P3338, DOI 10.1128/JVI.73.4.3338-3350.1999
  2. Boucher A, 2007, CLIN IMMUNOL, V123, P258, DOI 10.1016/j.clim.2007.02.002
  3. Desforges M, 2014, VIRUS RES, V194, P145, DOI 10.1016/j.virusres.2014.09.011
  4. Dessau RB, 2001, ACTA NEUROPATHOL, V101, P601
  5. Gu J, 2005, J EXP MED, V202, P415, DOI 10.1084/jem.20050828
  6. HOVANEC DL, 1983, INFECT IMMUN, V41, P426, DOI 10.1128/IAI.41.1.426-429.1983
  7. Moriguchi T, 2020, INT J INFECT DIS, V94, P55, DOI 10.1016/j.ijid.2020.03.062
  8. Netland J, 2008, J VIROL, V82, P7264, DOI 10.1128/JVI.00737-08
  9. Thompson AJ, 2018, LANCET NEUROL, V17, P162, DOI 10.1016/S1474-4422(17)30470-2
  10. Zubair AS, 2020, JAMA NEUROL, V77, P1018, DOI 10.1001/jamaneurol.2020.2065

Coleções
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/46
Artigos e Materiais de Revistas Científicas - LIM/52
Artigos e Materiais de Revistas Científicas - ODS/03