Acquisition, Persistence, and Clearance of Human Papillomavirus Infection Among Male Virgins Residing in Brazil, Mexico, and the United States

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLIU, Zhiyue
dc.contributor.authorNYITRAY, Alan G.
dc.contributor.authorHWANG, Lu-Yu
dc.contributor.authorSWARTZ, Michael D.
dc.contributor.authorABRAHAMSEN, Martha
dc.contributor.authorLAZCANO-PONCE, Eduardo
dc.contributor.authorVILLA, Luisa L.
dc.contributor.authorGIULIANO, Anna R.
dc.date.accessioned2018-05-08T14:31:16Z
dc.date.available2018-05-08T14:31:16Z
dc.date.issued2018
dc.description.abstractBackground. Little is known about the natural history of human papillomavirus (HPV) infection in male virgins. This study estimated the incidence and clearance of genital HPV infection and the factors associated with these measures among men who denied at baseline ever having penetrative sex. Methods. A cohort of 4123 men residing in Brazil, Mexico, and the United States were followed every 6 months for up to 10 visits. Genital exfoliated cells were collected and genotyped for 36 HPV types. Eighty-seven men were classified as virgins and included for analysis. Cox proportional hazards models identified factors associated with the incidence and clearance of genital HPV infection. Results. The incidence rates for any HPV infection among virgins who did and those who did not initiate sex during follow-up were 26.2 and 14.6 cases/1000 person-months, respectively. After penetrative sex initiation, 45.5% of men acquired HPV within 24 months. Younger age, current smoking, no recent female sex partners, and prevalent HPV infection were associated with high-risk HPV clearance. Conclusion. Virgins who did not initiate sex during follow-up still acquired HPV infection, possibly through nonpenetrative sexual contact. Further prospective cohort studies are needed to better understand factors associated with HPV acquisition and clearance in male virgins and recent nonvirgins.
dc.description.indexMEDLINE
dc.description.sponsorshipNational Cancer Institute, National Institutes of Health [R01CA09880301-A1]
dc.description.sponsorshipCancer Prevention Research Institute of Texas [CPRIT RP170668]
dc.identifier.citationJOURNAL OF INFECTIOUS DISEASES, v.217, n.5, p.767-776, 2018
dc.identifier.doi10.1093/infdis/jix588
dc.identifier.eissn1537-6613
dc.identifier.issn0022-1899
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/26304
dc.language.isoeng
dc.publisherOXFORD UNIV PRESS INC
dc.relation.ispartofJournal of Infectious Diseases
dc.rightsrestrictedAccess
dc.rights.holderCopyright OXFORD UNIV PRESS INC
dc.subjectHuman papillomavirus
dc.subjectmale
dc.subjectvirgins
dc.subjectincidence
dc.subjectpersistence
dc.subjectclearance
dc.subject.othervaginal intercourse
dc.subject.othersexual-behavior
dc.subject.otherhpv infection
dc.subject.othermen him
dc.subject.othercohort
dc.subject.otherprevalence
dc.subject.otherstudents
dc.subject.wosImmunology
dc.subject.wosInfectious Diseases
dc.subject.wosMicrobiology
dc.titleAcquisition, Persistence, and Clearance of Human Papillomavirus Infection Among Male Virgins Residing in Brazil, Mexico, and the United States
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryMéxico
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisomx
hcfmusp.author.externalLIU, Zhiyue:Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA
hcfmusp.author.externalNYITRAY, Alan G.:Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA; Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Infect Dis, Houston, TX 77030 USA
hcfmusp.author.externalHWANG, Lu-Yu:Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA; Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Infect Dis, Houston, TX 77030 USA
hcfmusp.author.externalSWARTZ, Michael D.:Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Biostat, Houston, TX 77030 USA
hcfmusp.author.externalABRAHAMSEN, Martha:H Lee Moffitt Canc Ctr & Res Inst, Ctr Infect Res Canc, Tampa, FL USA
hcfmusp.author.externalLAZCANO-PONCE, Eduardo:Inst Nacl Salud Publ, Cuernavaca, Morelos, Mexico
hcfmusp.author.externalGIULIANO, Anna R.:H Lee Moffitt Canc Ctr & Res Inst, Ctr Infect Res Canc, Tampa, FL USA
hcfmusp.citation.scopus14
hcfmusp.contributor.author-fmusphcLUISA LINA VILLA
hcfmusp.description.beginpage767
hcfmusp.description.endpage776
hcfmusp.description.issue5
hcfmusp.description.volume217
hcfmusp.origemWOS
hcfmusp.origem.pubmed29165581
hcfmusp.origem.scopus2-s2.0-85044532825
hcfmusp.origem.wosWOS:000425390100011
hcfmusp.publisher.cityCARY
hcfmusp.publisher.countryUSA
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