Postmenopausal hormone therapy in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): who still uses it?

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorAQUINO, Estela M. L.
dc.contributor.authorALMEIDA, Maria-da-Conceicao C.
dc.contributor.authorMENEZES, Greice M. S.
dc.contributor.authorFIGUEIREDO, Roberta Carvalho de
dc.contributor.authorBENSENOR, Isabela M.
dc.contributor.authorMENGUE, Sotero Serrate
dc.contributor.authorFONSECA, Maria de Jesus M. da
dc.contributor.authorGABRIELLI, Ligia
dc.date.accessioned2016-10-17T16:35:35Z
dc.date.available2016-10-17T16:35:35Z
dc.date.issued2016
dc.description.abstractPurposeWe aim to investigate the patterns of hormone therapy (HT) use and associated factors in women participating in the Brazilian Longitudinal Study of Adult Health. MethodsThis study included 3281 naturally menopausal women of 40 to 74years of age at enrollment to the Brazilian Longitudinal Study of Adult Health study, who answered questions regarding their use and discontinuation of HT. Prevalence rates of current and previous HT use were calculated, and a multinomial logistic regression model was constructed to simultaneously analyze the associated factors. ResultsThe prevalence of HT use increased from 1995 onwards, peaking at 55.7% in 1997. A sharp decline occurred in the decade beginning in 2000, reaching 11.1% at the study baseline interview (2008-2010). Current use was associated with being 60years of age (Relative Risk Ratio (RRR): 1.81; 95%CI: 1.10-2.96), divorced (RRR: 1.72; 95%CI: 1.14-2.60), or married (RRR: 2.09; 95%CI: 1.41-3.10); having a university education (RRR: 1.66; 95%CI: 1.14-2.40) or postgraduate degree (RRR: 2.45; 95%CI: 1.80-3.35); and having private health insurance (RRR: 2.86; 95%CI: 2.00-4.09). Body mass index 30kg/m(2) was inversely associated with HT use (RRR: 0.37; 95%CI: 0.26-0.53) as was the presence of at least one contraindication to HT use (RRR: 0.63; 95%CI: 0.44-0.89). Of the current users 60years of age, 79.1% had been using HT for at least 5years, and 73.6% had been menopausal for at least 10years. ConclusionAlthough the use of HT has declined in Brazil, the women who continue using it are largely exceeding evidence-based limits of age, time since menopause, and time of use.
dc.description.indexMEDLINE
dc.description.sponsorshipDepartment of Science and Technology of the Brazilian Ministry of Health
dc.description.sponsorshipBrazilian Ministry of Science and Technology
dc.description.sponsorshipNational Research Council/CNPq [01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ]
dc.identifier.citationPHARMACOEPIDEMIOLOGY AND DRUG SAFETY, v.25, n.6, p.609-617, 2016
dc.identifier.doi10.1002/pds.3992
dc.identifier.eissn1099-1557
dc.identifier.issn1053-8569
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/16096
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofPharmacoepidemiology and Drug Safety
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY-BLACKWELL
dc.subjectpostmenopause
dc.subjecthormone therapy
dc.subjectinappropriate use
dc.subjectdrug use
dc.subjectdeveloping countries
dc.subjectpharmacoepidemiology
dc.subjectpharmacoepidemiology
dc.subject.otherestrogen plus progestin
dc.subject.otherreplacement therapy
dc.subject.otherbreast-cancer
dc.subject.othermillion women
dc.subject.othercare
dc.subject.othergynecologists
dc.subject.othermenopause
dc.subject.otherstatement
dc.subject.othertrial
dc.subject.otherpublication
dc.subject.wosPublic, Environmental & Occupational Health
dc.subject.wosPharmacology & Pharmacy
dc.titlePostmenopausal hormone therapy in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): who still uses it?
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalAQUINO, Estela M. L.:Univ Fed Bahia, Inst Saude Colet, Salvador, BA, Brazil
hcfmusp.author.externalALMEIDA, Maria-da-Conceicao C.:Fundacao Oswaldo Cruz Fiocruz, Ctr Pesquisas Goncalo Moniz, Salvador, BA, Brazil
hcfmusp.author.externalMENEZES, Greice M. S.:Univ Fed Bahia, Inst Saude Colet, Salvador, BA, Brazil
hcfmusp.author.externalFIGUEIREDO, Roberta Carvalho de:Univ Fed Sao Joao Del Rei, Campus Ctr Oeste Dona Lindu, Divinopolis, MG, Brazil
hcfmusp.author.externalMENGUE, Sotero Serrate:Univ Fed Rio Grande do Sul, Fac Med, Programa Posgrad Epidemiol, Porto Alegre, RS, Brazil
hcfmusp.author.externalFONSECA, Maria de Jesus M. da:Fiocruz MS, Escola Nacl Saude Publ, BR-21045900 Rio De Janeiro, RJ, Brazil
hcfmusp.author.externalGABRIELLI, Ligia:Univ Fed Bahia, Inst Saude Colet, Salvador, BA, Brazil; Secretaria Saude Estado Bahia, Ctr Diabet & Endocrinol Estado Bahia, Salvador, BA, Brazil
hcfmusp.citation.scopus3
hcfmusp.contributor.author-fmusphcISABELA JUDITH MARTINS BENSEñOR
hcfmusp.description.beginpage609
hcfmusp.description.endpage617
hcfmusp.description.issue6
hcfmusp.description.volume25
hcfmusp.origemWOS
hcfmusp.origem.pubmed27028575
hcfmusp.origem.scopus2-s2.0-84973460165
hcfmusp.origem.wosWOS:000378548800001
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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