Interleukin 10 (IL10) and transforming growth factor beta 1 (TGF beta 1) gene polymorphisms in persistent IgE-mediated cow's milk allergy

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorJACOB, Cristina Miuki Abe
dc.contributor.authorPASTORINO, Antonio Carlos
dc.contributor.authorOKAY, Thelma Suely
dc.contributor.authorCASTRO, Ana Paula B. M.
dc.contributor.authorGUSHKEN, Andrea Keiko F.
dc.contributor.authorWATANABE, Leticia Aki
dc.contributor.authorFRUCCHI, Vanessa C. Z.
dc.contributor.authorOLIVEIRA, Lea Campos de
dc.date.accessioned2014-01-28T22:25:56Z
dc.date.available2014-01-28T22:25:56Z
dc.date.issued2013
dc.description.abstractOBJECTIVES: The aim of this cross-sectional study was to evaluate whether interleukin 10 (IL10) and transforming growth factor beta 1 (TGF beta 1) gene polymorphisms were associated with persistent IgE-mediated cow's milk allergy in 50 Brazilian children. The diagnostic criteria were anaphylaxis triggered by cow's milk or a positive double-blind, placebo-controlled food challenge. Tolerance was defined as the absence of a clinical response to a double-blind, placebo-controlled food challenge or cow's milk exposure. METHOD: The genomic DNA of the 50 patients and 224 healthy controls (HCs) was used to investigate five IL10 gene polymorphisms (-3575A/T, -2849A/G, -2763A/C, -1082G/A, -592C/A) and one TGF beta 1 polymorphism (-509C/T). RESULTS: Among the five IL10 polymorphisms analyzed, homozygosis for the G allele at the -1082 position was significantly higher in the patients compared with the healthy controls (p = 0.027) and in the persistent cow's milk allergy group compared with the healthy controls (p = 0.001). CONCLUSIONS: Homozygosis for the G allele at the IL10 -1082G/A polymorphism is associated with the persistent form of cow's milk allergy.
dc.description.indexMEDLINE
dc.description.sponsorshipConselho Nacional de Pesquisa - CNPq [475707/2007-9 - Edital - MCT/CNPq 15/2007, 308105/2012-5]
dc.identifier.citationCLINICS, v.68, n.7, p.1004-1009, 2013
dc.identifier.doi10.6061/clinics/2013(07)19
dc.identifier.issn1807-5932
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/4174
dc.language.isoeng
dc.publisherHOSPITAL CLINICAS, UNIV SAO PAULO
dc.relation.ispartofClinics
dc.rightsopenAccess
dc.rights.holderCopyright HOSPITAL CLINICAS, UNIV SAO PAULO
dc.subjectFood Hypersensitivity
dc.subjectCow's Milk Allergy
dc.subjectClinical Outcome
dc.subjectGene Polymorphism
dc.subjectInterleukin 10
dc.subjectTransforming Growth Factor beta 1
dc.subject.othersingle nucleotide polymorphisms
dc.subject.otherfood allergy
dc.subject.otherpromoter polymorphisms
dc.subject.otheratopic-dermatitis
dc.subject.othert-cells
dc.subject.otherchildren
dc.subject.otherasthma
dc.subject.otherassociation
dc.subject.otheril-10
dc.subject.otherpopulation
dc.subject.wosMedicine, General & Internal
dc.titleInterleukin 10 (IL10) and transforming growth factor beta 1 (TGF beta 1) gene polymorphisms in persistent IgE-mediated cow's milk allergy
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalGUSHKEN, Andrea Keiko F.:Univ Sao Paulo, Fac Med, Dept Pediat, Allergy & Immunol Unit, Sao Paulo, Brazil
hcfmusp.author.externalWATANABE, Leticia Aki:Univ Sao Paulo, Fac Med, Dept Pediat, Allergy & Immunol Unit, Sao Paulo, Brazil
hcfmusp.author.externalFRUCCHI, Vanessa C. Z.:Univ Sao Paulo, Fac Med, Dept Pediat, Allergy & Immunol Unit, Sao Paulo, Brazil
hcfmusp.citation.scopus15
hcfmusp.contributor.author-fmusphcCRISTINA MIUKI ABE JACOB
hcfmusp.contributor.author-fmusphcANTONIO CARLOS PASTORINO
hcfmusp.contributor.author-fmusphcTHELMA SUELY OKAY
hcfmusp.contributor.author-fmusphcANA PAULA BELTRAN MOSCHIONE CASTRO
hcfmusp.contributor.author-fmusphcLEA CAMPOS DE OLIVEIRA
hcfmusp.description.beginpage1004
hcfmusp.description.endpage1009
hcfmusp.description.issue7
hcfmusp.description.volume68
hcfmusp.origemWOS
hcfmusp.origem.pubmed23917667
hcfmusp.origem.scieloSCIELO:S1807-59322013000701004
hcfmusp.origem.scopus2-s2.0-84881035185
hcfmusp.origem.wosWOS:000322601600019
hcfmusp.publisher.citySAO PAULO
hcfmusp.publisher.countryBRAZIL
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hcfmusp.remissive.sponsorshipCNPq
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