Attention deficit hyperactivity disorder in the light of the epigenetic paradigm

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSCHUCH, Viviane
dc.contributor.authorUTSUMI, Daniel Augusto
dc.contributor.authorCOSTA, Thais Virginia Moura Machado
dc.contributor.authorKULIKOWSKI, Leslie Domenici
dc.contributor.authorMUSZKATI, Mauro
dc.date.accessioned2016-07-04T14:06:22Z
dc.date.available2016-07-04T14:06:22Z
dc.date.issued2015
dc.description.abstractAttention deficit hyperactivity disorder (ADHD) is a highly prevalent neurodevelopmental disorder characterized by a definite behavioral pattern that might lead to performance problems in the social, educational, or work environments. In the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, the symptoms of ADHD were restricted to those associated with cognitive (attention deficit) and behavioral (hyperactivity/impulsivity) deficits, while deficient emotional self-regulation, a relevant source of morbidity, was left out. The etiology of it is complex, as its exact causes have not yet been fully elucidated. ADHD seems to arise from a combination of various genetic and environmental factors that alter the developing brain, resulting in structural and functional abnormalities. The aim of this paper was to review epigenetics and ADHD focused on how multidimensional mechanisms influence the behavioral phenotype.
dc.description.indexPubMed
dc.identifier.citationFRONTIERS IN PSYCHIATRY, v.6, article ID 126, 7p, 2015
dc.identifier.doi10.3389/fpsyt.2015.00126
dc.identifier.issn1664-0640
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/14073
dc.language.isoeng
dc.publisherFRONTIERS MEDIA SA
dc.relation.ispartofFrontiers in Psychiatry
dc.rightsopenAccess
dc.rights.holderCopyright FRONTIERS MEDIA SA
dc.subjectADHD
dc.subjectexecutive functions
dc.subjectemotional self-regulation
dc.subjectDESR
dc.subjectgenetic factors
dc.subjectenvironmental factors
dc.subjectepigenetics
dc.subject.otheremotional self-regulation
dc.subject.otherdopamine transporter genotype
dc.subject.othergene-environment interactions
dc.subject.othercool executive function
dc.subject.otherdeficit/hyperactivity disorder
dc.subject.othersib-pairs
dc.subject.otherneuropsychological profile
dc.subject.otherpsychiatric-disorders
dc.subject.otherprenatal smoking
dc.subject.otherlinkage analysis
dc.titleAttention deficit hyperactivity disorder in the light of the epigenetic paradigm
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSCHUCH, Viviane:Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, Ctr Paulista Neuropsicol, Nucleo Atendimento Neuropsicol Infantil Interdisc, BR-04039060 Sao Paulo, Brazil
hcfmusp.author.externalUTSUMI, Daniel Augusto:Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, Ctr Paulista Neuropsicol, Nucleo Atendimento Neuropsicol Infantil Interdisc, BR-04039060 Sao Paulo, Brazil
hcfmusp.author.externalMUSZKATI, Mauro:Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, Ctr Paulista Neuropsicol, Nucleo Atendimento Neuropsicol Infantil Interdisc, BR-04039060 Sao Paulo, Brazil
hcfmusp.citation.scopus46
hcfmusp.contributor.author-fmusphcTHAIS VIRGINIA MOURA MACHADO COSTA
hcfmusp.contributor.author-fmusphcLESLIE DOMENICI KULIKOWSKI
hcfmusp.description.articlenumber126
hcfmusp.description.volume6
hcfmusp.origemWOS
hcfmusp.origem.pubmed26441687
hcfmusp.origem.scopus2-s2.0-84944736980
hcfmusp.origem.wosWOS:000364994900001
hcfmusp.publisher.cityLAUSANNE
hcfmusp.publisher.countrySWITZERLAND
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