A Model-Based Strategy to Control the Spread of Carbapenem-Resistant Enterobacteriaceae: Simulate and Implement

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art_DALBEN_A_ModelBased_Strategy_to_Control_the_Spread_of_2016.PDF (481.3 KB)
Citações na Scopus
19
Tipo de produção
article
Data de publicação
2016
DOI
Scopus
Web of Science
PubMed
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Editora
CAMBRIDGE UNIV PRESS
Autores
FIGUEIREDO, Walquiria Barcelos de
Citação
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, v.37, n.11, p.1315-1322, 2016
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Resumo
OBJECTIVE. To reduce transmission of carbapenem-resistant Enterobacteriaceae (CRE) in an intensive care unit with interventions based on simulations by a developed mathematical model. DESIGN. Before-after trial with a 44-week baseline period and 24-week intervention period. SETTING. Medical intensive care unit of a tertiary care teaching hospital. PARTICIPANTS. All patients admitted to the unit. METHODS. We developed a model of transmission of CRE in an intensive care unit and measured all necessary parameters for the model input. Goals of compliance with hand hygiene and with isolation precautions were established on the basis of the simulations and an intervention was focused on reaching those metrics as goals. Weekly auditing and giving feedback were conducted. RESULTS. The goals for compliance with hand hygiene and contact precautions were reached on the third week of the intervention period. During the baseline period, the calculated R0 was 11; the median prevalence of patients colonized by CRE in the unit was 33%, and 3 times it exceeded 50%. In the intervention period, the median prevalence of colonized CRE patients went to 21%, with a median weekly Rn of 0.42 (range, 0-2.1). CONCLUSIONS. The simulations helped establish and achieve specific goals to control the high prevalence rates of CRE and reduce CRE transmission within the unit. The model was able to predict the observed outcomes. To our knowledge, this is the first study in infection control to measure most variables of a model in real life and to apply the model as a decision support tool for intervention.
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https://observatorio.fm.usp.br/handle/OPI/17182
Referências
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - FM/MLS
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/01
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