The validity and reliability of the CAMDEX-DS for assessing dementia in adults with Down syndrome in Brazil

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art_FONSECA_The_validity_and_reliability_of_the_CAMDEXDS_for_2019.PDF (246.8 KB)
Citações na Scopus
14
Tipo de produção
article
Data de publicação
2019
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ASSOC BRASILEIRA PSIQUIATRIA
Autores
HADDAD, Glenda G.
OLIVEIRA, Melaine C. de
ZAMAN, Shahid
HOLLAND, Anthony J.
Citação
REVISTA BRASILEIRA DE PSIQUIATRIA, v.41, n.3, p.225-233, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: Alzheimer's disease occurs at a higher prevalence and an earlier age in individuals with Down syndrome (DS) than typically developing individuals. However, diagnosing dementia in individuals with intellectual disability remains a challenge due to pre-existing cognitive deficits. The aim of this study was to investigate the validity and reliability of the Brazilian version of the Cambridge Examination for Mental Disorders of Older People with Down's syndrome and Others with Intellectual Disabilities (CAMDEX-DS) for individuals with DS. Methods: Two psychiatrists, working independently, evaluated 92 adults with DS >= 30 years of age. The concurrent validity of the CAMDEX-DS was analyzed in relation to the gold standard of established international criteria. In a subgroup of 20 subjects, the concurrent validity of the CAM DEX-DS was analyzed in relation to an independent objective assessment of cognitive decline over three years. We analyzed the inter-rater reliability of cognitive assessment. Results: The diagnostic accuracy of the CAMDEX-DS compared to the gold standard was 96.7%. CAMDEX-DS-based diagnosis was considered consistent with cognitive decline. The probability of a participant with dementia having cognitive decline was 83%. Inter-rater reliability for the participant assessment was good, with a kappa of > 0.8 for 93% of the CAMDEX-DS items. Conclusion: The CAMDEX-DS can be considered the first valid and reliable instrument for evaluating dementia in adults with DS in Brazil. Its use in such individuals could improve clinical practice and research.
Palavras-chave
Alzheimer disease, Down syndrome, diagnosis, dementia, intellectual disability
URI
https://observatorio.fm.usp.br/handle/OPI/33175
Referências
  1. American Psychiatric Association, 2013, DIAGN STAT MAN MENT
  2. Annus T, 2017, NEUROBIOL AGING, V53, P11, DOI 10.1016/j.neurobiolaging.2017.01.009
  3. Annus T, 2016, ALZHEIMERS DEMENT, V12, P538, DOI 10.1016/j.jalz.2015.07.490
  4. Gili JA, 2016, BIRTH DEFECTS RES A, V106, P257, DOI 10.1002/bdra.23481
  5. Aprahamian I, 2011, J ALZHEIMERS DIS, V26, P221, DOI 10.3233/JAD-2011-110125
  6. Azevedo D, 2008, DEMENT GERIATR COGN, V25, P491, DOI 10.1159/000128275
  7. Ball SL, 2008, BRIT J CLIN PSYCHOL, V47, P1, DOI 10.1348/014466507X230967
  8. Ball SL, 2004, J INTELL DISABIL RES, V48, P611, DOI 10.1111/j.1365-2788.2004.00630.x
  9. Beacher F, 2005, ARCH GEN PSYCHIAT, V62, P1360, DOI 10.1001/archpsyc.62.12.1360
  10. Bottino C. M. C., 2001, ARQ NEUROPSIQUIAT S3, V59, pS20
  11. Cole JH, 2017, NEUROBIOL AGING, V56, P41, DOI 10.1016/j.neurobiolaging.2017.04.006
  12. CUMMINGS JL, 1994, NEUROLOGY, V44, P2308, DOI 10.1212/WNL.44.12.2308
  13. Deb S, 2007, BRIT J PSYCHIAT, V190, P440, DOI 10.1192/bjp.bp.106.024984
  14. Esteba-Castillo S, 2013, REV NEUROLOGIA, V57, P337, DOI 10.33588/rn.5708.2013259
  15. EVENHUIS HM, 1992, J INTELL DISABIL RES, V36, P337
  16. Fletcher R, 2007, DIAGNOSTIC MANUAL IN
  17. Fonseca LM, 2016, CAMDEX DS EXAME CAMB
  18. Fonseca LM, 2018, NEUROPSYCHOLOGICAL A, P123
  19. Fonseca LM, 2016, DEMENT GERIATR COGN, V41, P123, DOI 10.1159/000442941
  20. Fonseca LM, 2014, NEUROPSYCH DIS TREAT, V10, P2209, DOI 10.2147/NDT.S68831
  21. Forlenza OV, 2005, PSYCHOPHARMACOLOGY, V180, P359, DOI 10.1007/s00213-005-2168-8
  22. GRACE J, 2001, FRONTAL SYSTEMS BEHA
  23. Harris PA, 2009, J BIOMED INFORM, V42, P377, DOI 10.1016/j.jbi.2008.08.010
  24. Hon J, 1999, BRIT J CLIN PSYCHOL, V38, P155, DOI 10.1348/014466599162719
  25. JORM AF, 1989, PSYCHOL MED, V19, P1015, DOI 10.1017/S0033291700005742
  26. Kimura R, 2007, HUM MOL GENET, V16, P15, DOI 10.1093/hmg/ddl437
  27. Landt J, 2011, J NEUROENDOCRINOL, V23, P450, DOI 10.1111/j.1365-2826.2011.02118.x
  28. LEJEUNE J, 1959, CR HEBD ACAD SCI, V248, P1721
  29. Lipnicki DM, 2017, PLOS MED, V14, DOI 10.1371/journal.pmed.1002261
  30. McPaul A, 2017, J APPL RES INTELLECT, V30, P824, DOI 10.1111/jar.12273
  31. Neale N, 2018, NEUROIMAGE-CLIN, V17, P263, DOI 10.1016/j.nicl.2017.10.022
  32. Parker SE, 2010, BIRTH DEFECTS RES A, V88, P1008, DOI 10.1002/bdra.20735
  33. Petersen RC, 2014, J INTERN MED, V275, P214, DOI 10.1111/joim.12190
  34. Prasher V, 2004, RES DEV DISABIL, V25, P385, DOI 10.1016/j.ridd.2003.12.002
  35. ROTH M, 1986, BRIT J PSYCHIAT, V149, P698, DOI 10.1192/bjp.149.6.698
  36. Vardarajan BN, 2014, JAMA NEUROL, V71, P315, DOI 10.1001/jamaneurol.2013.5570
  37. Wechsler D., 1981, MANUAL WECHSLER ADUL
  38. WISNIEWSKI KE, 1985, ANN NEUROL, V17, P278, DOI 10.1002/ana.410170310
  39. World Health Organization (WHO), 1992, ICD10 INT STAT CLASS
  40. Wu JH, 2013, EUR J HUM GENET, V21, P943, DOI 10.1038/ejhg.2012.288
  41. Zigman WB, 2013, DEV DISABIL RES REV, V18, P51, DOI 10.1002/ddrr.1128

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/21
Artigos e Materiais de Revistas Científicas - LIM/23