Periodic limb movements during sleep and restless legs syndrome in patients with ASIA A spinal cord injury

Objective: To establish the occurrence of Periodic Leg Movements (PLM) and Restless Legs Syndrome (RLS) in Spinal Cord Injury (SCI) subjects. Methods: In this study, twenty four patients were submitted to a full night polysomnography and were assessed with Epworth Sleepiness Scale and an adapted form of International Restless Legs Syndrome Scale Rating Scale (IRLS Rating Scale). Control Group (CG) was composed of 16 subjects, 50% of each sex, age: 24.38 +/- 4 years old. Spinal Cord Injury Group (SCIG) was composed of 8 subjects (29 +/- 5 years old) with a complete SCI (ASIA A) of about three and a half years of duration, 100% males. Results: 100% of SCIG had RLS compared to 17% in CG ( p < 0.0001). SCIG had 18.11 +/- 20.07 of PLM index while CG had 5.96 +/- 11.93 (p = 0.01). Arousals related to PLM were recorded in CG and SCIG. There was a positive moderate correlation between RLS and age (r = 0.5; p = 0.01), RLS and PLM (r = 0.49; p = 0.01), adapted IRLS Rating Scale and PLM index (r = 0.64; p = 0.03) and also a negative moderate correlation between Epworth Sleepiness Scale and PLM index (r = -0.4; p = 0.04) in both groups. Conclusion: RLS and PLM are common findings in SCI patients with a complete injury.

Palavras-chave

Spinal cord injury, Restless legs syndrome, Periodic leg movements, Central pattern generator

URI

https://observatorio.fm.usp.br/handle/OPI/23122

Referências

*AM AC SLEEP MED, 2001, INT CLASS SLEEP DIS, P208
Molinari M, 2009, BRAIN RES BULL, V78, P22, DOI 10.1016/j.brainresbull.2008.02.030
Darian-Smith C, 2009, NEUROSCIENTIST, V15, P149, DOI 10.1177/1073858408331372
Lai YY, 2008, NEUROSCIENCE, V154, P431, DOI 10.1016/j.neuroscience.2008.03.085
Paulus W, 2006, SLEEP MED REV, V10, P185, DOI 10.1016/j.smrv.2006.01.004
Tassinari CA, 2009, REV NEUROL-FRANCE, V165, P762, DOI 10.1016/j.neurol.2009.08.002
Waxman SG, 2006, TRENDS NEUROSCI, V29, P207, DOI 10.1016/j.tins.2006.02.003
Tang JS, 2009, PROG NEUROBIOL, V89, P383, DOI 10.1016/j.pneurobio.2009.10.002
Wrigley PJ, 2009, PAIN, V141, P52, DOI 10.1016/j.pain.2008.10.007
Ferri R, 2007, CLIN NEUROPHYSIOL, V118, P438, DOI 10.1016/j.clinph.2006.10.007
Sforza E, 2002, CLIN NEUROPHYSIOL, V113, P883, DOI 10.1016/S1388-2457(02)00066-4
WALTERS AS, 1995, MOVEMENT DISORD, V10, P634, DOI 10.1002/mds.870100517
Lapointe NP, 2009, J PHYSIOL-LONDON, V587, P1499, DOI 10.1113/jphysiol.2008.166314
Aguilar J, 2010, J NEUROSCI, V30, P7528, DOI 10.1523/JNEUROSCI.0379-10.2010
Barriere G, 2005, PROG NEUROBIOL, V77, P139, DOI 10.1016/j.pneurobio.2005.10.007
Endo T, 2007, BRAIN, V130, P2951, DOI 10.1093/brain/awm237
Kang SG, 2007, PROG NEURO-PSYCHOPH, V31, P1078, DOI 10.1016/j.pnpbp.2007.03.011
Montplaisir J, 1996, SLEEP, V19, P196
Masuko AH, 2008, ARQ NEURO-PSIQUIAT, V66, P832, DOI 10.1590/S0004-282X2008000600011
de Mello MT, 1999, SPINAL CORD, V37, P634, DOI 10.1038/sj.sc.3100909
deMello MT, 1996, SPINAL CORD, V34, P294
DICKEL MJ, 1994, SLEEP, V17, P733
Endo T, 2009, NEUROSCIENTIST, V15, P291, DOI 10.1177/1073858408329508
Esteves AM, 2007, SPINAL CORD, V45, P360, DOI 10.1038/sj.sc.3101971
Giummarra MJ, 2010, MED HYPOTHESES, V74, P968, DOI 10.1016/j.mehy.2009.12.009
Haggstram FM, 2009, ARQ NEURO-PSIQUIAT, V67, P822, DOI 10.1590/S0004-282X2009000500008
JOHNS MW, 1991, SLEEP, V14, P540
Lai YY, 1999, NEUROSCIENCE, V90, P469, DOI 10.1016/S0306-4522(98)00429-1
Mello MT, 1997, SPINAL CORD, V35, P248, DOI 10.1038/sj.sc.3100408
Rechtschaffen A, 1968, MANUAL STANDARDISED
Skidmore FM, 2009, J NEUROL NEUROSUR PS, V80, P569, DOI 10.1136/jnnp.2008.152652
van Hedel HJA, 2010, RESTOR NEUROL NEUROS, V28, P123, DOI 10.3233/RNN-2010-0508
Wu M, 2009, EXP BRAIN RES, V193, P225, DOI 10.1007/s00221-008-1614-3
Yezierski RP, 2009, J REHABIL RES DEV, V46, P95, DOI 10.1682/JRRD.2008.06.0074

Coleções

Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/45

Página do item completo