Factors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazil

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFERRUFINO, Rosario Quiroga
dc.contributor.authorRODRIGUES, Camila
dc.contributor.authorFIGUEIREDO, Gerusa Maria
dc.contributor.authorGLEISON, Daniel
dc.contributor.authorYAPURA, Silvia
dc.contributor.authorMATOS, Maria Laura Mariano de
dc.contributor.authorWITKIN, Steven S. S.
dc.contributor.authorMENDES-CORREA, Maria Cassia
dc.date.accessioned2023-04-14T18:00:47Z
dc.date.available2023-04-14T18:00:47Z
dc.date.issued2023
dc.description.abstractIntroduction: The objective of the present study was to describe the clinical and epidemiological aspects of recently acquired hepatitis C virus (HCV) infection and the frequency of its spontaneous clearance in a people living with the human immunodeficiency virus (PLWH) cohort. Methods: We reviewed the medical records from all PLWH at the human immunodeficiency virus (HIV) outpatient reference clinic affiliated with the University of Sao Paulo, Brazil, and identified, by immunoassays and RNA-PCR individuals who acquired HCV infection between January 2015 and December 2017. The factors associated with subsequent spontaneous clearance of the infection in this group were identified and analyzed. Results: Among 3143 PLWH individuals, 362 (11.5%) were coinfected with HCV. Forty-eight (13.2%) of these subjects first became HCV-positive between January 2015 and December 2017. Spontaneous HCV clearance was documented in 23 individuals (47.9%). The majority of this latter group were male (83.3%), and the median age was 31 years (23-39). The main risk group for HCV acquisition was men who had sex with men (MSM) (89.5%). In a multivariate analysis, only an elevated CD4+ T lymphocyte count at the time of seroconversion was found to be associated with subsequent HCV clearance (p = 0.025). Conclusions: In HIV-infected individuals in Sao Paulo, Brazil, most cases of recent HCV transmission were by sexual exposure. In PLWH, particularly in MSM, the individual's CD4+ T lymphocyte count is a determinant of whether an acquired HCV infection will be prolonged or will spontaneously clear.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.identifier.citationVIRUSES-BASEL, v.15, n.2, article ID 314, 10p, 2023
dc.identifier.doi10.3390/v15020314
dc.identifier.eissn1999-4915
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/53052
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofViruses-Basel
dc.rightsopenAccesseng
dc.rights.holderCopyright MDPIeng
dc.subjectHIVeng
dc.subjectcoinfectioneng
dc.subjectrecently acquired hepatitis C infectioneng
dc.subjectspontaneous clearanceeng
dc.subjectimmunityeng
dc.subjectacute HCVeng
dc.subject.otherinjecting drug-userseng
dc.subject.othersexual transmissioneng
dc.subject.otherinfectioneng
dc.subject.otherhcveng
dc.subject.otherreinfectioneng
dc.subject.otherresponseseng
dc.subject.othercoupleseng
dc.subject.othercohorteng
dc.subject.otheril28beng
dc.subject.otherhosteng
dc.subject.wosVirologyeng
dc.titleFactors Associated with Spontaneous Clearance of Recently Acquired Hepatitis C Virus among HIV-Positive Men in Brazileng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus2
hcfmusp.contributor.author-fmusphcROSARIO QUIROGA FERRUFINO
hcfmusp.contributor.author-fmusphcCAMILA RODRIGUES
hcfmusp.contributor.author-fmusphcGERUSA MARIA FIGUEIREDO
hcfmusp.contributor.author-fmusphcDANIEL GLEISON CARVALHO
hcfmusp.contributor.author-fmusphcSILVIA MONICA YAPURA JALDIN
hcfmusp.contributor.author-fmusphcMARIA LAURA MARIANO DE MATOS
hcfmusp.contributor.author-fmusphcSTEVEN SOL WITKIN
hcfmusp.contributor.author-fmusphcMARIA CASSIA JACINTHO MENDES CORREA
hcfmusp.description.articlenumber314
hcfmusp.description.issue2
hcfmusp.description.volume15
hcfmusp.origemWOS
hcfmusp.origem.pubmed36851529
hcfmusp.origem.scopus2-s2.0-85148971184
hcfmusp.origem.wosWOS:000942004700001
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
hcfmusp.relation.referenceAbdel-Hakeem MS, 2014, GASTROENTEROLOGY, V147, P870, DOI 10.1053/j.gastro.2014.07.005eng
hcfmusp.relation.referenceAisyah DN, 2018, J VIRAL HEPATITIS, V25, P680, DOI 10.1111/jvh.12866eng
hcfmusp.relation.referenceAmerican Association for the Study of Liver Diseases and Infectios Diseases Society of America, REC TEST MAN TREAT Heng
hcfmusp.relation.referenceARCA, 3 LEV NAC US DROG PEeng
hcfmusp.relation.referenceBenova L, 2014, CLIN INFECT DIS, V59, P765, DOI 10.1093/cid/ciu447eng
hcfmusp.relation.referenceBlach S, 2022, LANCET GASTROENTEROL, V7, P396, DOI 10.1016/S2468-1253(21)00472-6eng
hcfmusp.relation.referenceBrasil Ministerio da Saude, 2013, IMPL ROT TEST DEAC N, V1steng
hcfmusp.relation.referenceBrasil. Ministerio da Saude, 2021, B EP HEP VIReng
hcfmusp.relation.referenceDanta M, 2008, J INFECT DIS, V197, P1558, DOI 10.1086/587843eng
hcfmusp.relation.referenceGrebely J, 2012, LANCET INFECT DIS, V12, P408, DOI 10.1016/S1473-3099(12)70010-5eng
hcfmusp.relation.referenceKenny-Walsh E, 1999, NEW ENGL J MED, V340, P1228, DOI 10.1056/NEJM199904223401602eng
hcfmusp.relation.referenceLemon SM, 2010, J BIOL CHEM, V285, P22739, DOI 10.1074/jbc.R109.099556eng
hcfmusp.relation.referenceLuetkemeyer A, 2006, JAIDS-J ACQ IMM DEF, V41, P31, DOI 10.1097/01.qai.0000191281.77954.27eng
hcfmusp.relation.referenceMarincovich B, 2003, SEX TRANSM INFECT, V79, P160, DOI 10.1136/sti.79.2.160eng
hcfmusp.relation.referenceMarx MA, 2003, CLIN INFECT DIS, V37, P514, DOI 10.1086/376639eng
hcfmusp.relation.referenceMatthews GV, 2008, J HEPATOL, V49, P305, DOI 10.1016/j.jhep.2008.06.005eng
hcfmusp.relation.referenceMatthews GV, 2007, AIDS, V21, P2112, DOI 10.1097/QAD.0b013e3282ef3873eng
hcfmusp.relation.referenceVieira PCM, 2017, TRANSFUSION, V57, P1968, DOI 10.1111/trf.14146eng
hcfmusp.relation.referenceNascimbeni M, 2003, J VIROL, V77, P4781, DOI 10.1128/JVI.77.8.4781-4793.2003eng
hcfmusp.relation.referenceOliveira AB, 2019, BMC INFECT DIS, V19, DOI 10.1186/s12879-019-4270-2eng
hcfmusp.relation.referenceRoudot-Thoraval F, 2021, CLIN RES HEPATOL GAS, V45, DOI 10.1016/j.clinre.2020.101596eng
hcfmusp.relation.referenceRoy K, 2002, EPIDEMIOL INFECT, V129, P577, DOI 10.1017/S0950268802007902eng
hcfmusp.relation.referenceSeaberg EC, 2015, CLIN INFECT DIS, V61, P1381, DOI 10.1093/cid/civ562eng
hcfmusp.relation.referenceSerpaggi J, 2006, AIDS, V20, P233, DOI 10.1097/01.aids.0000200541.40633.56eng
hcfmusp.relation.referenceSilva FQ, 2018, ARCH VIROL, V163, P617, DOI 10.1007/s00705-017-3656-yeng
hcfmusp.relation.referenceSoriano V, 2008, J INFECT DIS, V198, P1337, DOI 10.1086/592171eng
hcfmusp.relation.referenceTengan FM, 2016, BMC INFECT DIS, V16, DOI 10.1186/s12879-016-1988-yeng
hcfmusp.relation.referenceTerrault NA, 2013, HEPATOLOGY, V57, P881, DOI 10.1002/hep.26164eng
hcfmusp.relation.referenceThomas DL, 2009, NATURE, V461, P798, DOI 10.1038/nature08463eng
hcfmusp.relation.referenceThomas DL, 2000, JAMA-J AM MED ASSOC, V284, P450, DOI 10.1001/jama.284.4.450eng
hcfmusp.relation.referenceThursz M, 2014, NAT REV GASTRO HEPAT, V11, P28, DOI 10.1038/nrgastro.2013.179eng
hcfmusp.relation.referenceTillmann HL, 2010, GASTROENTEROLOGY, V139, P1586, DOI 10.1053/j.gastro.2010.07.005eng
hcfmusp.relation.referenceUrbani S, 2006, HEPATOLOGY, V44, P126, DOI 10.1002/hep.21242eng
hcfmusp.relation.referencevan de Laar T, 2009, GASTROENTEROLOGY, V136, P1609, DOI 10.1053/j.gastro.2009.02.006eng
hcfmusp.relation.referencevan de Laar TJW, 2007, J INFECT DIS, V196, P230, DOI 10.1086/518796eng
hcfmusp.relation.referencevan den Berg CHBS, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0027555eng
hcfmusp.relation.referenceVandelli C, 2004, AM J GASTROENTEROL, V99, P855, DOI 10.1111/j.1572-0241.2004.04150.xeng
hcfmusp.relation.referenceWang CC, 2007, J INFECT DIS, V196, P1474, DOI 10.1086/522608eng
hcfmusp.relation.referenceWiese M, 2005, J HEPATOL, V43, P590, DOI 10.1016/j.jhep.2005.04.007eng
hcfmusp.scopus.lastupdate2024-05-10
relation.isAuthorOfPublication139dc0c4-4c38-41be-9f51-35d52a4f8bfa
relation.isAuthorOfPublication64cbb30e-fc31-46f2-b3bb-4f3709ccc161
relation.isAuthorOfPublicationcde5ba58-0f39-401e-b12f-5b57134621f4
relation.isAuthorOfPublicationf346d323-8807-4734-abea-de03d8396f36
relation.isAuthorOfPublicatione7d9d9f4-9f0e-489d-8d92-3e27ea2a3edb
relation.isAuthorOfPublication96feb27e-a571-4891-a59e-d86593902d01
relation.isAuthorOfPublication1b8dfcc8-906a-4df2-91c2-3c7c7b08f46d
relation.isAuthorOfPublication4ec4044d-75d1-4d30-8176-efd04b22c8d6
relation.isAuthorOfPublication.latestForDiscovery139dc0c4-4c38-41be-9f51-35d52a4f8bfa
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
art_FERRUFINO_Factors_Associated_with_Spontaneous_Clearance_of_Recently_Acquired_.PDF
Tamanho:
282.96 KB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - FM/MPR
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/52
Artigos e Materiais de Revistas Científicas - ODS/03
Artigos e Materiais de Revistas Científicas - ODS/05