Ambient levels of concentrated PM2.5 affects cell kinetics in adrenal glands: an experimental study in mice

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFUCHS, Luiz Fernando Portugal
dc.contributor.authorVERAS, Mariana Matera
dc.contributor.authorSALDIVA, Paulo Hilario Nascimento
dc.contributor.authorSASSO, Gisela Rodrigues da Silva
dc.contributor.authorCARVALHO, Katia Candido
dc.contributor.authorSIMOES, Manuel de Jesus
dc.contributor.authorSOARES JR., Jose Maria
dc.contributor.authorBARACAT, Edmund Chada
dc.date.accessioned2017-10-24T13:21:54Z
dc.date.available2017-10-24T13:21:54Z
dc.date.issued2017
dc.description.abstractWe evaluated the effects of air pollution on the adrenal cortex using 30 female mice divided into two groups of fifteen animals each. One group was conditioned daily in a chamber with exposure to particulate matter (PM) 2.5 mu m (GExp). Animals were exposed on daily basis in an ambient particles concentrator during the period of time enough to reach an accumulated dose of 600 mu g/m(3), which corresponds to a 24-h exposure of 25 mu g/m(3) that approximates to the annual mean of PM2.5 in Sao Paulo. The other group was allocated to another chamber with filtered air (GCrt). After euthanasia, the adrenals underwent histological processing and immunohistochemistry staining for Ki-67 and cleaved caspase-3. Histomorphometry of the adrenal glands in GExp showed increased thickness of the zona glomerulosa, while in GCrt; the adrenal glands from GExp had higher Ki-67 immunostaining scores in the zona reticularis than those from GCrt. The adrenal from GExp showed higher cleaved caspase-3 immunoreactivity in the zona fasciculata than the unexposed group (GCrt). The homeostasis index indicated higher cell proliferation in the zona glomerulosa and zona reticularis in GExp than in GCrt. Our data indicate that PM2.5 air pollution induces alterations on cell kinetics in mouse adrenal glands.
dc.description.indexMEDLINE
dc.identifier.citationGYNECOLOGICAL ENDOCRINOLOGY, v.33, n.6, p.490-495, 2017
dc.identifier.doi10.1080/09513590.2017.1291617
dc.identifier.eissn1473-0766
dc.identifier.issn0951-3590
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/22020
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofGynecological Endocrinology
dc.rightsrestrictedAccess
dc.rights.holderCopyright TAYLOR & FRANCIS LTD
dc.subjectAdrenal
dc.subjectmouse
dc.subjectPM2.5
dc.subjecttraffic
dc.subjecturban pollution
dc.subject.otherair-pollution
dc.subject.otherparticulate matter
dc.subject.otheroxidative stress
dc.subject.othergene-expression
dc.subject.otherhealth
dc.subject.othertoxicity
dc.subject.othercortex
dc.subject.otherlead
dc.subject.wosEndocrinology & Metabolism
dc.subject.wosObstetrics & Gynecology
dc.titleAmbient levels of concentrated PM2.5 affects cell kinetics in adrenal glands: an experimental study in mice
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalFUCHS, Luiz Fernando Portugal:Univ Sao Paulo FMUSP, Dept Obstet & Ginecol, Lab Invest Med LIM 58, Disciplina Ginecol,Hosp Clin,Fac Med, Sao Paulo, Brazil
hcfmusp.author.externalSASSO, Gisela Rodrigues da Silva:Univ Fed Sao Paulo, Escola Paulista Med, Disciplina Histol & Biol Estrutural, Dept Morfol & Genet, Sao Paulo, Brazil
hcfmusp.author.externalSIMOES, Manuel de Jesus:Univ Fed Sao Paulo, Escola Paulista Med, Disciplina Histol & Biol Estrutural, Dept Morfol & Genet, Sao Paulo, Brazil
hcfmusp.citation.scopus8
hcfmusp.contributor.author-fmusphcMARIANA MATERA VERAS
hcfmusp.contributor.author-fmusphcPAULO HILARIO NASCIMENTO SALDIVA
hcfmusp.contributor.author-fmusphcKATIA CANDIDO CARVALHO
hcfmusp.contributor.author-fmusphcJOSE MARIA SOARES JUNIOR
hcfmusp.contributor.author-fmusphcEDMUND CHADA BARACAT
hcfmusp.description.beginpage490
hcfmusp.description.endpage495
hcfmusp.description.issue6
hcfmusp.description.volume33
hcfmusp.origemWOS
hcfmusp.origem.pubmed28277123
hcfmusp.origem.scopus2-s2.0-85014450506
hcfmusp.origem.wosWOS:000407685700017
hcfmusp.publisher.cityABINGDON
hcfmusp.publisher.countryENGLAND
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