Accumulation of trace element content in the lungs of Sao Paulo city residents and its correlation to lifetime exposure to air pollution

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSANTOS, Nathalia Villa dos
dc.contributor.authorVIEIRA, Carolina Leticia Zilli
dc.contributor.authorSALDIVA, Paulo Hilario Nascimento
dc.contributor.authorANDRE, Carmen Diva Saldiva De
dc.contributor.authorMAZZILLI, Barbara Paci
dc.contributor.authorANDRADE, Maria de Fatima
dc.contributor.authorSAUEIA, Catia Heloisa
dc.contributor.authorSAIKI, Mitiko
dc.contributor.authorVERAS, Mariana Matera
dc.contributor.authorKOUTRAKIS, Petros
dc.date.accessioned2023-08-16T18:02:50Z
dc.date.available2023-08-16T18:02:50Z
dc.date.issued2022
dc.description.abstractHeavy metals are natural and essential elements of the environment and living beings, produced from natural (e.g. volcanic activity and cosmic ray-induced spallation) and anthropogenic processes (e.g. industrial and fossil fuel combustion). High-concentrations of heavy metals and radionuclides are also originated from anthropogenic activities in urban and industrial areas. In this preliminary study, we analyzed the levels of heavy metals and Polonium-210 (Po-210) in lung tissues in autopsies from residents of the city of Sao Paulo, SP, Brazil. In order to identify the link among sources of the heavy metals in lungs, factor analysis was performed. Of the first four factors, which explain 66% of the total variability, three were associated with vehicular sources. The fitting of a regression model with Po-210 as the response variable and with the four factors as explanatory variables, controlling for age, sex and tobacco, showed a significant association between the concentration of polonium and the first factor that is generated by catalysts and brakes (coefficient = 0.90, standard error = 0.33, p = 0.016). Our findings suggest an association between traffic-related trace metals and Po-210 in lung autopsies.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP) [13/21728-2, 16/23129-7, 16/22793-0, 16/03461-7]
dc.description.sponsorshipConselho Nacional de DesenvolvimentoCientifico e Tecnologico (CNPq) [304126/2015-2, 300835/957]
dc.description.sponsorshipU.S. Environmental Protection Agency (U.S. EPA) [RD-83479801, RD-83587201]
dc.identifier.citationSCIENTIFIC REPORTS, v.12, n.1, 2022
dc.identifier.doi10.1038/s41598-022-15048-2
dc.identifier.issn2045-2322
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/54798
dc.language.isoeng
dc.publisherNATURE PORTFOLIOeng
dc.relation.ispartofScientific Reports
dc.rightsopenAccesseng
dc.rights.holderCopyright NATURE PORTFOLIOeng
dc.subjectAcidente Vascular Cerebral
dc.subjectAlta do Paciente
dc.subjectEncaminhamento e Consulta Reabilitação
dc.subject.otherfine particulate mattereng
dc.subject.otherheavy-metalseng
dc.subject.otherradoneng
dc.subject.othercomponentseng
dc.subject.otherimpacteng
dc.subject.wosMultidisciplinary Scienceseng
dc.titleAccumulation of trace element content in the lungs of Sao Paulo city residents and its correlation to lifetime exposure to air pollutioneng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalVIEIRA, Carolina Leticia Zilli:Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA
hcfmusp.author.externalANDRE, Carmen Diva Saldiva De:Univ Sao Paulo, Inst Math & Stat, Sao Paulo, Brazil
hcfmusp.author.externalMAZZILLI, Barbara Paci:IPEN CNEN, Nucl & Energy Res Inst, Sao Paulo, SP, Brazil
hcfmusp.author.externalANDRADE, Maria de Fatima:Univ Sao Paulo, Inst Astron Geophys & Atmospher Sci, Atmospher Sci Dept, Sao Paulo, Brazil
hcfmusp.author.externalSAUEIA, Catia Heloisa:IPEN CNEN, Nucl & Energy Res Inst, Sao Paulo, SP, Brazil
hcfmusp.author.externalSAIKI, Mitiko:IPEN CNEN, Nucl & Energy Res Inst, Sao Paulo, SP, Brazil
hcfmusp.author.externalKOUTRAKIS, Petros:Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA
hcfmusp.citation.scopus3
hcfmusp.contributor.author-fmusphcNATHALIA VILLA DOS SANTOS
hcfmusp.contributor.author-fmusphcPAULO HILARIO NASCIMENTO SALDIVA
hcfmusp.contributor.author-fmusphcMARIANA MATERA VERAS
hcfmusp.description.issue1
hcfmusp.description.volume12
hcfmusp.origemWOS
hcfmusp.origem.pubmed35773451
hcfmusp.origem.scopus2-s2.0-85133252813
hcfmusp.origem.wosWOS:001014944000033
hcfmusp.publisher.cityBERLINeng
hcfmusp.publisher.countryGERMANYeng
hcfmusp.relation.referenceAdams K, 2015, J AIR WASTE MANAGE, V65, P544, DOI 10.1080/10962247.2014.1001884eng
hcfmusp.relation.referenceAmbiente M. D. M., 2018, RESOLUCAO 491 DE 19eng
hcfmusp.relation.referenceBourotte Christine Laure Marie, 2011, Rev. bras. meteorol., V26, P419, DOI 10.1590/S0102-77862011000300008eng
hcfmusp.relation.referenceBradl HB, 2005, INTERFACE SCI TECHNO, V6, P1eng
hcfmusp.relation.referenceCatalani Simona, 2008, Acta Biomed, V79 Suppl 1, P52eng
hcfmusp.relation.referenceCooper Ross G, 2008, Indian J Occup Environ Med, V12, P10, DOI 10.4103/0019-5278.40809eng
hcfmusp.relation.referenceTakano APC, 2019, ENVIRON RES, V173, P23, DOI 10.1016/j.envres.2019.03.006eng
hcfmusp.relation.referenceda Saude M., 2013, RESOLUCAO RDC 42 DEeng
hcfmusp.relation.referenceDarby S, 2001, ANN ONCOL, V12, P1341, DOI 10.1023/A:1012518223463eng
hcfmusp.relation.referenceDavis JA, 2011, SCI TOTAL ENVIRON, V409, P5129, DOI 10.1016/j.scitotenv.2011.08.013eng
hcfmusp.relation.referencede Miranda RM, 2018, J CLEAN PROD, V202, P253, DOI 10.1016/j.jclepro.2018.08.100eng
hcfmusp.relation.referenceDesMarias Thomas Liborio, 2019, Current Opinion in Toxicology, V14, P1, DOI 10.1016/j.cotox.2019.05.003eng
hcfmusp.relation.referenceEnvironmental T, ENV BEH POLeng
hcfmusp.relation.referenceFajersztajn L, 2013, NAT REV CANCER, V13, P674, DOI 10.1038/nrc3572eng
hcfmusp.relation.referenceFlora SJS, 2008, INDIAN J MED RES, V128, P501eng
hcfmusp.relation.referenceFortoul TI, 1996, ENVIRON HEALTH PERSP, V104, P630, DOI 10.2307/3433092eng
hcfmusp.relation.referenceGenchi G, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17030679eng
hcfmusp.relation.referenceGrigoratos T. M. G., PUBLICATIONS OFFICE, P225, DOI [10.4324/9781315596198-20, DOI 10.4324/9781315596198-20]eng
hcfmusp.relation.referenceHamidatou L., 2013, IMAGING RADIOANALYTI, DOI 10.5772/53686eng
hcfmusp.relation.referenceHuffman GP, 2000, J AIR WASTE MANAGE, V50, P1106, DOI 10.1080/10473289.2000.10464157eng
hcfmusp.relation.referenceIqbal M, 2018, INDO AM J PHARM SCI, V5, P6236, DOI 10.5281/zenodo.1307376eng
hcfmusp.relation.referenceJaishankar Monisha, 2014, Interdiscip Toxicol, V7, P60, DOI 10.2478/intox-2014-0009eng
hcfmusp.relation.referenceJohnson R.A., 2007, APPL MULTIVARIATE ST, V6th ed.eng
hcfmusp.relation.referenceJoint WHWHO., 2007, HLTH RISKS HEAV METeng
hcfmusp.relation.referenceKOLLMEIER H, 1990, BRIT J IND MED, V47, P682eng
hcfmusp.relation.referenceLevy JI, 2012, AM J EPIDEMIOL, V175, P1091, DOI 10.1093/aje/kwr457eng
hcfmusp.relation.referenceMacCallum RC, 1999, PSYCHOL METHODS, V4, P84, DOI 10.1037/1082-989x.4.1.84eng
hcfmusp.relation.referenceMDM AMBIENTE, RES 491 DE 19 DE NOVeng
hcfmusp.relation.reference( NSCEP) NSC for EP, AIR POLL ASP ASP ZINeng
hcfmusp.relation.referenceNyhan MM, 2019, ENVIRON INT, V130, DOI 10.1016/j.envint.2019.04.066eng
hcfmusp.relation.referencePereira GM, 2017, ATMOS CHEM PHYS, V17, P11943, DOI 10.5194/acp-17-11943-2017eng
hcfmusp.relation.referencePopoola LT, 2018, INT J ENVIRON SCI TE, V15, P935, DOI 10.1007/s13762-017-1454-4eng
hcfmusp.relation.referencePORSTENDORFER J, 1994, J AEROSOL SCI, V25, P219, DOI 10.1016/0021-8502(94)90077-9eng
hcfmusp.relation.referencePrasher D, 2009, NOISE HEALTH, V11, P141, DOI 10.4103/1463-1741.53358eng
hcfmusp.relation.referenceR Core Team, 2018, R CORE TEAM R LAND Eeng
hcfmusp.relation.referenceRehman K, 2018, J CELL BIOCHEM, V119, P157, DOI 10.1002/jcb.26234eng
hcfmusp.relation.referenceSchlesinger RB, 2007, INHAL TOXICOL, V19, P811, DOI 10.1080/08958370701402382eng
hcfmusp.relation.referenceTsuchiyama F, 1997, INT ARCH OCC ENV HEA, V70, P77, DOI 10.1007/s004200050190eng
hcfmusp.relation.referenceTurner MC, 2012, EUR RESPIR J, V39, P1113, DOI 10.1183/09031936.00058211eng
hcfmusp.relation.referenceU.S. Department of Health and Human Services, 2004, TOXICOLOGICAL PROFILeng
hcfmusp.relation.referenceVilla N., 2020, LEVELS POLONIUM 210, P1, DOI [10.1038/s41598-019-56973-z, DOI 10.1038/S41598-019-56973-Z]eng
hcfmusp.relation.referenceWEITZENFELD H, 1992, Boletin de la Oficina Sanitaria Panamericana, V112, P97eng
hcfmusp.relation.referenceWong CSC, 2006, ENVIRON POLLUT, V142, P1, DOI 10.1016/j.envpol.2005.09.004eng
hcfmusp.scopus.lastupdate2024-05-17
relation.isAuthorOfPublicationab185f19-b3f7-4f94-9c99-bb2b7811cbf9
relation.isAuthorOfPublicationcb8ac601-f702-4f9a-9d07-7f10579e68d5
relation.isAuthorOfPublication85bcd09e-21bd-4181-9ad6-4076f04aa019
relation.isAuthorOfPublication.latestForDiscoveryab185f19-b3f7-4f94-9c99-bb2b7811cbf9
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
art_SANTOS_Accumulation_of_trace_element_content_in_the_lungs_2022.PDF
Tamanho:
1.36 MB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - ODS/03
Artigos e Materiais de Revistas Científicas - ODS/11