Young ""Healthy"" Smokers Have Functional and Inflammatory Changes in the Nasal and the Lower Airways

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorNICOLA, Marina Lazzari
dc.contributor.authorCARVALHO, Heraclito Barbosa de
dc.contributor.authorYOSHIDA, Carolina Tieko
dc.contributor.authorANJOS, Fabyana Maria dos
dc.contributor.authorNAKAO, Mayumi
dc.contributor.authorSANTOS, Ubiratan de Paula
dc.contributor.authorCARDOZO, Karina Helena Morais
dc.contributor.authorCARVALHO, Valdemir Melechco
dc.contributor.authorPINTO, Ernani
dc.contributor.authorFARSKY, Sandra Helena Poliselli
dc.contributor.authorSALDIVA, Paulo Hilario Nascimento
dc.contributor.authorRUBIN, Bruce K.
dc.contributor.authorNAKAGAWA, Naomi Kondo
dc.date.accessioned2014-09-30T14:45:16Z
dc.date.available2014-09-30T14:45:16Z
dc.date.issued2014
dc.description.abstractBackground: Smoking is responsible for most COPD. Although people with COPD often have concomitant nasal disease, there are few studies that report physiologic or inflammatory changes in the upper airways in young asymptomatic smokers. We investigated physiologic and inflammatory changes in the nasal and lower airways of young smokers and if these changes were related to smoking history. Methods: Seventy-two subjects aged between 18 and 35 years (32 healthy nonsmokers and 40 young smokers) participated in this study. We measured nasal mucociliary clearance (MCC), nasal mucus surface contact angle, cell counts, myeloperoxidase and cytokine concentrations in nasal lavage fluid, exhaled breath condensate (EBC) pH, and lung function. Results: Smokers had faster MCC, an increased number of cells (macrophages, ciliated cells, and goblet cells), increased lavage myeloperoxidase concentration, and decreased EBC pH compared with nonsmokers. There was a significant inverse relationship between pack-year smoking history and EBC pH. There were no differences in lung function or mucus surface properties comparing smokers to nonsmokers. Conclusions: Young adult smokers have functional and inflammatory changes in the nasal and lower airways and these correlate with smoking history. However, in these young smokers, smoking history was not associated with pulmonary function decline, probably because it is unlikely that spirometry detects early physiologic changes in the airways.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP] [13/13598-1, 13/11401-6]
dc.identifier.citationCHEST, v.145, n.5, p.998-1005, 2014
dc.identifier.doi10.1378/chest.13-1355
dc.identifier.issn0012-3692
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/7682
dc.language.isoeng
dc.publisherAMER COLL CHEST PHYSICIANS
dc.relation.ispartofChest
dc.rightsrestrictedAccess
dc.rights.holderCopyright AMER COLL CHEST PHYSICIANS
dc.subject.otherobstructive pulmonary-disease
dc.subject.otherexhaled breath condensate
dc.subject.otherciliary beat frequency
dc.subject.othermucociliary clearance
dc.subject.othersystemic inflammation
dc.subject.othercigarette-smoking
dc.subject.othertobacco-smoke
dc.subject.otherlavage
dc.subject.othersputum
dc.subject.othermacrophages
dc.subject.wosCritical Care Medicine
dc.subject.wosRespiratory System
dc.titleYoung ""Healthy"" Smokers Have Functional and Inflammatory Changes in the Nasal and the Lower Airways
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalANJOS, Fabyana Maria dos:Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-01246903 Sao Paulo, Brazil
hcfmusp.author.externalCARDOZO, Karina Helena Morais:Fleury Med & Hlth Inst, Sao Paulo, Brazil
hcfmusp.author.externalCARVALHO, Valdemir Melechco:Fleury Med & Hlth Inst, Sao Paulo, Brazil
hcfmusp.author.externalPINTO, Ernani:Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-01246903 Sao Paulo, Brazil
hcfmusp.author.externalFARSKY, Sandra Helena Poliselli:Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-01246903 Sao Paulo, Brazil
hcfmusp.author.externalRUBIN, Bruce K.:Virginia Commonwealth Univ, Sch Med, Dept Pediat, Richmond, VA USA
hcfmusp.citation.scopus40
hcfmusp.contributor.author-fmusphcMARINA LAZZARI NICOLA
hcfmusp.contributor.author-fmusphcHERACLITO BARBOSA DE CARVALHO
hcfmusp.contributor.author-fmusphcCAROLINA TIEKO YOSHIDA
hcfmusp.contributor.author-fmusphcMAYUMI NAKAO
hcfmusp.contributor.author-fmusphcUBIRATAN DE PAULA SANTOS
hcfmusp.contributor.author-fmusphcPAULO HILARIO NASCIMENTO SALDIVA
hcfmusp.contributor.author-fmusphcNAOMI KONDO NAKAGAWA
hcfmusp.description.beginpage998
hcfmusp.description.endpage1005
hcfmusp.description.issue5
hcfmusp.description.volume145
hcfmusp.origemWOS
hcfmusp.origem.pubmed24307008
hcfmusp.origem.scopus2-s2.0-84899791594
hcfmusp.origem.wosWOS:000336532100016
hcfmusp.publisher.cityNORTHBROOK
hcfmusp.publisher.countryUSA
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