Characteristics of aquaporin 1, 3, and 5 expression during early murine salivary gland development

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPAULA, Fernanda de
dc.contributor.authorTUCKER, Abigail S.
dc.contributor.authorTESHIMA, Tathyane Harumi N.
dc.contributor.authorSOUZA, Milena Monteiro de
dc.contributor.authorCOUTINHO-CAMILLO, Claudia Malheiros
dc.contributor.authorNICO, Marcello Menta S.
dc.contributor.authorLOURENCO, Silvia Vanessa
dc.date.accessioned2021-02-18T13:28:32Z
dc.date.available2021-02-18T13:28:32Z
dc.date.issued2021
dc.description.abstractAquaporins (AQPs) are essential to coordinate the transit of water and ions through the cell membrane. In salivary glands (SGs), AQPs have been associated with saliva formation, facilitating water absorption through the epithelium during the formation of hypotonic saliva, which is then secreted into the oral cavity. Different members of the AQP family have been suggested to play distinct roles during embryonic development, highlighted by their specific expression patterns. Here, we have investigated the expression patterns of AQP-1, AQP-3 and AQP-5 by immunofluorescence at key stages of salivary gland development, utilising cultured mouse embryonic submandibular (SMG) and sublingual (SLG) glands. The expression of AQPs was compared to a mitotic marker, phospho-histone 3 (PH3), a myoepithelial marker, smooth muscle actin (SMA), and a vascular marker, CD31. Qualitative analysis revealed that AQP-1 and AQP-3 were primarily expressed during the earlier phases of SG morphogenesis and were associated with cells undergoing mitotic processes (PH3-positive). AQP-5, in contrast, was not associated to mitotic figures, but was predominantly expressed during late stages of SG morphogenesis. Our results highlight that AQPs are expressed from early stages of SG morphogenesis and exhibit complimentary expression patterns that may contribute to the morphogenesis of salivary glands.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel SuperiorCAPES [88881.188920/2018-01]
dc.identifier.citationJOURNAL OF ANATOMY, v.238, n.3, p.794-806, 2021
dc.identifier.doi10.1111/joa.13336
dc.identifier.eissn1469-7580
dc.identifier.issn0021-8782
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/39158
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofJournal of Anatomy
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright WILEYeng
dc.subjectaquaporineng
dc.subjectdevelopmenteng
dc.subjectexpressioneng
dc.subjectmitosiseng
dc.subjectsalivary glandeng
dc.subject.otherwater channeleng
dc.subject.othercell-migrationeng
dc.subject.otherproliferationeng
dc.subject.otherlocalizationeng
dc.subject.othersecretioneng
dc.subject.otherroleseng
dc.subject.othercycleeng
dc.subject.otheraqp5eng
dc.subject.othermiceeng
dc.subject.wosAnatomy & Morphologyeng
dc.titleCharacteristics of aquaporin 1, 3, and 5 expression during early murine salivary gland developmenteng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryisogb
hcfmusp.author.externalPAULA, Fernanda de:Univ Sao Paulo, Dent Sch, Gen Pathol Dept, Av Prof Lineu Prestes 2227, BR-05508000 Sao Paulo, SP, Brazil
hcfmusp.author.externalTUCKER, Abigail S.:Kings Coll London, Ctr Craniofacial & Regenerat Biol, London, England
hcfmusp.author.externalTESHIMA, Tathyane Harumi N.:UCL Eastman Dent Inst, NIHR Clin Lecturer Oral Med, London, England
hcfmusp.author.externalSOUZA, Milena Monteiro de:AC Camargo Canc Ctr, Int Res Ctr, Sao Paulo, Brazil
hcfmusp.author.externalCOUTINHO-CAMILLO, Claudia Malheiros:AC Camargo Canc Ctr, Int Res Ctr, Sao Paulo, Brazil
hcfmusp.citation.scopus7
hcfmusp.contributor.author-fmusphcMARCELLO MENTA SIMONSEN NICO
hcfmusp.contributor.author-fmusphcSILVIA VANESSA LOURENCO
hcfmusp.description.beginpage794
hcfmusp.description.endpage806
hcfmusp.description.issue3
hcfmusp.description.volume238
hcfmusp.origemWOS
hcfmusp.origem.pubmed33078411
hcfmusp.origem.scopus2-s2.0-85092660790
hcfmusp.origem.wosWOS:000579341300001
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceAgre Peter, 2006, Proc Am Thorac Soc, V3, P5, DOI 10.1513/pats.200510-109JHeng
hcfmusp.relation.referenceAkamatsu T, 2003, PFLUG ARCH EUR J PHY, V446, P641, DOI 10.1007/s00424-003-1109-9eng
hcfmusp.relation.referenceAure MH, 2014, J MOL HISTOL, V45, P69, DOI 10.1007/s10735-013-9526-3eng
hcfmusp.relation.referenceAure MH, 2011, J MOL HISTOL, V42, P401, DOI 10.1007/s10735-011-9343-5eng
hcfmusp.relation.referenceBreslin JW, 2019, COMPR PHYSIOL, V9, P207, DOI 10.1002/cphy.c180015eng
hcfmusp.relation.referenceCalamita G, 2018, FRONT PHYSIOL, V9, DOI 10.3389/fphys.2018.00851eng
hcfmusp.relation.referenceChauvigne F, 2019, COMMUN BIOL, V2, DOI 10.1038/s42003-019-0713-yeng
hcfmusp.relation.referencede Paula F, 2017, J MOL HISTOL, V48, P329, DOI 10.1007/s10735-017-9731-6eng
hcfmusp.relation.referenceDelporte C, 1996, BIOCHEM BIOPH RES CO, V228, P223, DOI 10.1006/bbrc.1996.1645eng
hcfmusp.relation.referenceDelporte C, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17020166eng
hcfmusp.relation.referenceDelporte C, 2006, BBA-BIOMEMBRANES, V1758, P1061, DOI 10.1016/j.bbamem.2006.01.022eng
hcfmusp.relation.referenceGalan-Cobo A, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0137692eng
hcfmusp.relation.referenceGalan-Cobo A, 2016, J CELL PHYSIOL, V231, P243, DOI 10.1002/jcp.25078eng
hcfmusp.relation.referenceGresz V, 2001, AM J PHYSIOL-GASTR L, V281, pG247eng
hcfmusp.relation.referenceHara-Chikuma M, 2005, BIOL CELL, V97, P479eng
hcfmusp.relation.referenceHara-Chikuma M, 2008, J MOL MED-JMM, V86, P221, DOI 10.1007/s00109-007-0272-4eng
hcfmusp.relation.referenceHara-Chikuma M, 2006, J AM SOC NEPHROL, V17, P39, DOI 10.1681/ASN.2005080846eng
hcfmusp.relation.referenceHosseini ZF, 2018, J CELL SCI, V131, DOI 10.1242/jcs.208728eng
hcfmusp.relation.referenceHu J, 2006, FASEB J, V20, P1892, DOI 10.1096/fj.06-5930fjeeng
hcfmusp.relation.referenceHua Y, 2019, BIOSCIENCE REP, V39, DOI 10.1042/BSR20182303eng
hcfmusp.relation.referenceIanez RF, 2010, HISTOPATHOLOGY, V57, P410, DOI 10.1111/j.1365-2559.2010.03645.xeng
hcfmusp.relation.referenceIchiyama T, 2018, J ORAL SCI, V60, P212, DOI 10.2334/josnusd.17-0150eng
hcfmusp.relation.referenceKida H, 2005, J MEMBRANE BIOL, V208, P55, DOI 10.1007/s00232-005-0819-7eng
hcfmusp.relation.referenceKrane CM, 2001, J BIOL CHEM, V276, P23413, DOI 10.1074/jbc.M008760200eng
hcfmusp.relation.referenceLarsen HS, 2011, J MOL HISTOL, V42, P71, DOI 10.1007/s10735-010-9308-0eng
hcfmusp.relation.referenceLarsen HS, 2009, EUR J ORAL SCI, V117, P655, DOI 10.1111/j.1600-0722.2009.00695.xeng
hcfmusp.relation.referenceMa TH, 1999, J BIOL CHEM, V274, P20071, DOI 10.1074/jbc.274.29.20071eng
hcfmusp.relation.referenceMatsuki N, 2005, J MEMBRANE BIOL, V203, P119, DOI 10.1007/s00232-005-0736-9eng
hcfmusp.relation.referenceMatsuzaki T, 1999, CELL TISSUE RES, V295, P513, DOI 10.1007/s004410051257eng
hcfmusp.relation.referenceMatsuzaki T, 2012, ACTA HISTOCHEM CYTOC, V45, P251, DOI 10.1267/ahc.12018eng
hcfmusp.relation.referenceNakamura Moriyoshi, 2013, Kurume Med J, V60, P7eng
hcfmusp.relation.referenceQin YY, 2019, GENE EXPR PATTERNS, V32, P38, DOI 10.1016/j.gep.2019.04.001eng
hcfmusp.relation.referenceSaadoun S, 2005, NATURE, V434, P786, DOI 10.1038/nature03460eng
hcfmusp.relation.referenceSapmaz E, 2016, ACTA OTO-LARYNGOL, V136, P937, DOI 10.3109/00016489.2016.1165353eng
hcfmusp.relation.referenceTeymoortash A, 2012, IN VIVO, V26, P951eng
hcfmusp.relation.referenceTucker AS, 2007, SEMIN CELL DEV BIOL, V18, P237, DOI 10.1016/j.semcdb.2007.01.006eng
hcfmusp.relation.referenceVerkman AS, 2002, J ANAT, V200, P617, DOI 10.1046/j.1469-7580.2002.00058.xeng
hcfmusp.relation.referenceWang D, 2009, J MED INVESTIG, V56, P350, DOI 10.2152/jmi.56.350eng
hcfmusp.relation.referenceWang W, 2003, CALCIFIED TISSUE INT, V72, P222, DOI 10.1007/s00223-002-1014-9eng
hcfmusp.relation.referenceWellner RB, 2006, PFLUG ARCH EUR J PHY, V451, P642, DOI 10.1007/s00424-005-1489-0eng
hcfmusp.relation.referenceYang BX, 2005, AM J PHYSIOL-CELL PH, V288, pC1161, DOI 10.1152/ajpcell.00564.2004eng
hcfmusp.scopus.lastupdate2024-05-10
relation.isAuthorOfPublication9a2ec109-cd27-4dd8-b807-1404eb4e3d06
relation.isAuthorOfPublication5daa3ec5-b62d-4637-93ed-cc9082669dd4
relation.isAuthorOfPublication.latestForDiscovery9a2ec109-cd27-4dd8-b807-1404eb4e3d06
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
art_PAULA_Characteristics_of_aquaporin_1_3_and_5_expression_2021.PDF
Tamanho:
3.68 MB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - FM/MDT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/06