Significance of Aspergillus spp. isolation in defining cases of COVID-19 Associated Pulmonary Aspergillosis - CAPA

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCOCIO, Tiago Alexandre
dc.contributor.authorSIQUEIRA, Lumena Pereira Machado
dc.contributor.authorRICILUCA, Katie Cristina Takeuti
dc.contributor.authorGIMENES, Viviane Mazo Favero
dc.contributor.authorANDRADE, Tania Sueli de
dc.contributor.authorBENARD, Gil
dc.contributor.authorMARTINEZ, Roberto
dc.contributor.authorBOLLELA, Valdes Roberto
dc.date.accessioned2023-10-30T14:27:15Z
dc.date.available2023-10-30T14:27:15Z
dc.date.issued2023
dc.description.abstractCOVID-19-Associated Pulmonary Aspergillosis (CAPA) is a relatively common complica-tion in patients with severe forms of the disease caused by the SARS-CoV-2 virus. Diag-nosing and confirming CAPA is challenging. In this study, Aspergillus spp. isolation in respiratory specimens from patients with COVID-19 was evaluated for identifying cases of CAPA. In 2020-2021, 17 Aspergillus spp. were isolated from 15 COVID-19 patients admit-ted to a university hospital in Brazil. Patient records were retrospectively reviewed to obtain clinical-epidemiological data and other markers of Aspergillus spp. infection and then compared with the ECMM/ISHAM criteria for defining CAPA. Probable CAPA was defined in 5/10 patients, who had Aspergillus spp. isolated from Bronchoalveolar Lavage (BAL) or a positive galactomannan blood test. Additionally, anti-Aspergillus antibodies were detected in two of these patients, during active or follow-up phases of CAPA. In another seven patients with Aspergillus spp. isolated from tracheobronchial aspirate or sputum, CAPA was presumed, mainly due to deterioration of clinical conditions and new lung imaging suggestive of fungal infection. Antifungal agents to control CAPA, particu-larly voriconazole, were used in 9/15 cases. In cases of probable CAPA and remaining patients, clinical conditions and comorbidities were similar, with lethality being high, at 60% and 71%, respectively. The number of CAPA cases defined by scientific criteria was lower than that assumed in the clinical context. This was largely due to the lack of BAL collection for fungal culture and the non-intensive use of other markers of invasive asper-gillosis. The isolation of Aspergillus spp. in different respiratory specimens should alert clinicians to the diagnosis of CAPA.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipFoundation for the Support of Teaching, Research, and Medical Assistance of the Hospital das Clinicas of the Ribeirao Preto Medical School - FAEPA
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorship[150639/2022-8]
dc.identifier.citationBRAZILIAN JOURNAL OF INFECTIOUS DISEASES, v.27, n.4, article ID 102793, 10p, 2023
dc.identifier.doi10.1016/j.bjid.2023.102793
dc.identifier.eissn1678-4391
dc.identifier.issn1413-8670
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/56051
dc.language.isoeng
dc.publisherELSEVIER BRAZILeng
dc.relation.ispartofBrazilian Journal of Infectious Diseases
dc.rightsopenAccesseng
dc.rights.holderCopyright ELSEVIER BRAZILeng
dc.subjectCAPAeng
dc.subjectCOVID-19eng
dc.subjectMatrix-assisted laser desorptioneng
dc.subjectionizationeng
dc.subjectAspergillus sppeng
dc.subjectSARS-CoV-2eng
dc.subjectInvasive aspergillosiseng
dc.subject.wosInfectious Diseaseseng
dc.titleSignificance of Aspergillus spp. isolation in defining cases of COVID-19 Associated Pulmonary Aspergillosis - CAPAeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalRICILUCA, Katie Cristina Takeuti:Adolfo Lutz Inst, Dept Colecao Cultura, Sao Paulo, SP, Brazil
hcfmusp.author.externalANDRADE, Tania Sueli de:Adolfo Lutz Inst, Dept Colecao Cultura, Sao Paulo, SP, Brazil
hcfmusp.author.externalMARTINEZ, Roberto:Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, Ribeirao Preto, SP, Brazil
hcfmusp.author.externalBOLLELA, Valdes Roberto:Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, Ribeirao Preto, SP, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcTIAGO ALEXANDRE COCIO
hcfmusp.contributor.author-fmusphcLUMENA PEREIRA MACHADO SIQUEIRA
hcfmusp.contributor.author-fmusphcVIVIANE MAZO FAVERO GIMENES
hcfmusp.contributor.author-fmusphcGIL BENARD
hcfmusp.description.articlenumber102793
hcfmusp.description.issue4
hcfmusp.description.volume27
hcfmusp.origemWOS
hcfmusp.origem.pubmed37507102
hcfmusp.origem.scopus2-s2.0-85166344168
hcfmusp.origem.wosWOS:001057219500001
hcfmusp.publisher.cityRIO DE JANEIROeng
hcfmusp.publisher.countryBRAZILeng
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Artigos e Materiais de Revistas Científicas - FM/MDT
Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/53
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