Polymyxin-resistant Pseudomonas aeruginosa assigned as ST245: First report in an intensive care unit in Sao Paulo, Brazil

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorORSI, Tatiana D'Annibale
dc.contributor.authorPERDIGAO NETO, Lauro Vieira
dc.contributor.authorMARTINS, Roberta Cristina Ruedas
dc.contributor.authorLEVIN, Anna S.
dc.contributor.authorCOSTA, Silvia Figueiredo
dc.date.accessioned2019-05-30T13:35:32Z
dc.date.available2019-05-30T13:35:32Z
dc.date.issued2019
dc.description.abstractObjectives: Pseudomonas aeruginosa is a Gram-negative bacterium that causes severe infections, especially in hospitalised and immunocompromised patients. Polymyxins are the last therapeutic option to treat infections caused by this micro-organism. Here we describe a polymyxin-resistant P. aeruginosa assigned as sequence type (ST) 245 for the first time in Brazil. Methods: Antimicrobial susceptibility testing of the isolate was performed. In addition, whole-genome sequencing was performed and its virulence and resistance genes were analysed. Results: The P. aeruginosa ST245 isolate was identified for the first time in Brazil in a patient with ventilator-associated pneumonia hospitalised at Hospital das Clinicas, Sao Paulo. Analysis of the genome showed the presence of several resistance and virulence genes. Mutations in beta-lactam resistance genes were found in beta-lactamases, outer membrane proteins, efflux pump and penicillin-binding proteins. Polymorphisms related to pathways leading to polymyxin resistance are also present, such as lipid A or keto-deoxyoctulosonate modification with aminoarabinose as well as activation of lipopolysaccharide (LPS). Conclusion: Such findings may represent an alert for the spread of an unusual profile in the country.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipCAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
dc.identifier.citationJOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, v.16, p.147-149, 2019
dc.identifier.doi10.1016/j.jgar.2018.12.021
dc.identifier.eissn2213-7173
dc.identifier.issn2213-7165
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/31725
dc.language.isoeng
dc.publisherELSEVIER SCI LTDeng
dc.relation.ispartofJournal of Global Antimicrobial Resistance
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIER SCI LTDeng
dc.subjectPseudomonas aeruginosaeng
dc.subjectFosfomycineng
dc.subjectPolymyxin resistanceeng
dc.subject.othervirulenceeng
dc.subject.wosInfectious Diseaseseng
dc.subject.wosPharmacology & Pharmacyeng
dc.titlePolymyxin-resistant Pseudomonas aeruginosa assigned as ST245: First report in an intensive care unit in Sao Paulo, Brazileng
dc.typearticleeng
dc.type.categoryeditorial materialeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus4
hcfmusp.contributor.author-fmusphcTATIANA D'ANNIBALE ORSI
hcfmusp.contributor.author-fmusphcLAURO VIEIRA PERDIGAO NETO
hcfmusp.contributor.author-fmusphcROBERTA CRISTINA RUEDAS MARTINS
hcfmusp.contributor.author-fmusphcANNA SARA SHAFFERMAN LEVIN
hcfmusp.contributor.author-fmusphcSILVIA FIGUEIREDO COSTA
hcfmusp.description.beginpage147
hcfmusp.description.endpage149
hcfmusp.description.volume16
hcfmusp.origemWOS
hcfmusp.origem.pubmed30634055
hcfmusp.origem.scopus2-s2.0-85060197465
hcfmusp.origem.wosWOS:000461770500029
hcfmusp.publisher.cityOXFORDeng
hcfmusp.publisher.countryENGLANDeng
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hcfmusp.scopus.lastupdate2024-05-10
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