DSpace Collection: LIM/52 - Laboratório de VirologiaLIM/52 - Laboratório de Virologiahttps://observatorio.fm.usp.br/handle/OPI/38032024-03-28T13:50:17Z2024-03-28T13:50:17ZCone-beam computed tomography texture analysis can help differentiate odontogenic and non-odontogenic maxillary sinusitisCOSTA, Andre Luiz FerreiraFARDIM, Karolina Aparecida CastilhoRIBEIRO, Isabela TeixeiraJARDINI, Maria Aparecida NevesBRAZ-SILVA, Paulo HenriqueORHAN, KaanLOPES, Sergio Lucio Pereira de Castrohttps://observatorio.fm.usp.br/handle/OPI/582932024-02-15T15:01:10Z2023-01-01T00:00:00ZTitle: Cone-beam computed tomography texture analysis can help differentiate odontogenic and non-odontogenic maxillary sinusitis
Authors: COSTA, Andre Luiz Ferreira; FARDIM, Karolina Aparecida Castilho; RIBEIRO, Isabela Teixeira; JARDINI, Maria Aparecida Neves; BRAZ-SILVA, Paulo Henrique; ORHAN, Kaan; LOPES, Sergio Lucio Pereira de Castro
Abstract: Purpose: This study aimed to assess texture analysis (TA) of cone-beam computed tomography (CBCT) images as a quantitative tool for the differential diagnosis of odontogenic and non-odontogenic maxillary sinusitis (OS and NOS, respectively).Materials and Methods: CBCT images of 40 patients diagnosed with OS (N = 20) and NOS (N = 20) were evaluated. The gray level co-occurrence (GLCM) matrix parameters, and gray level run length matrix texture (GLRLM) parameters were extracted using manually placed regions of interest on lesion images. Seven texture parameters were calculated using GLCM and 4 parameters using GLRLM. The Mann-Whitney test was used for comparisons between the groups, and the Levene test was performed to confirm the homogeneity of variance (alpha = 5%).Results: The results showed statistically significant differences (P<0.05) between the OS and NOS patients regarding 3 TA parameters. NOS patients presented higher values for contrast, while OS patients presented higher values for correlation and inverse difference moment. Greater textural homogeneity was observed in the OS patients than in the NOS patients, with statistically significant differences in standard deviations between the groups for correlation, sum of squares, sum of entropy, and entropy.Conclusion: TA enabled quantitative differentiation between OS and NOS on CBCT images by using the parameters of contrast, correlation, and inverse difference moment. (Imaging Sci Dent 20220166)2023-01-01T00:00:00ZNoninvasive Techniques for Management of Erythema MultiformeMARTINS, FabianaPALLOS, DeboraCANDEIA, JodkandlysZERBINATI, RodrigoBRAZ-SILVA, Paulo HenriqueCAMPOS, Luanahttps://observatorio.fm.usp.br/handle/OPI/582942024-02-15T15:01:10Z2023-01-01T00:00:00ZTitle: Noninvasive Techniques for Management of Erythema Multiforme
Authors: MARTINS, Fabiana; PALLOS, Debora; CANDEIA, Jodkandlys; ZERBINATI, Rodrigo; BRAZ-SILVA, Paulo Henrique; CAMPOS, Luana
Abstract: An 18-year-old man was referred for a diagnosis of extensive oral lesions. During the interview, he reported a medical history of ganglionic tuberculosis, type 2 herpes infection, and significant weight loss due to dysphagia. Intraoral exam revealed multiple painful and ulcerated lesions covered by pseudomembrane. Lesions were observed on the labial and buccal mucosa, tongue, and soft palate. The laboratory findings included serum positivity for the Epstein-Barr virus, and salivary tests showed positive values for herpes simplex virus (HSV-2) and human herpesvirus (HHV-7). The diagnostic hypothesis was based on clinical findings and viral infection detected in the saliva, which triggered an immunological disorder, that is, erythema multiforme (EM). The treatment consisted of antimicrobial photodynamic therapy (aPDT), with substantial improvement in pain and healing as seen in the following twenty-four hours. Complete resolution of the lesions was achieved five days after the first session. Once the diagnosis of virus-induced EM was confirmed, noninvasive techniques (e.g., salivary tests and aPDT) were very successful and can be indicated for managing these lesions.2023-01-01T00:00:00ZTorquetenovirus: predictive biomarker or innocent bystander in pathogenesisTOZETTO-MENDOZA, Tania ReginaBRAZ-SILVA, Paulo HenriqueGIANNECCHINI, SimoneWITKIN, Steven S.https://observatorio.fm.usp.br/handle/OPI/577432024-03-07T06:08:28Z2023-01-01T00:00:00ZTitle: Torquetenovirus: predictive biomarker or innocent bystander in pathogenesis
Authors: TOZETTO-MENDOZA, Tania Regina; BRAZ-SILVA, Paulo Henrique; GIANNECCHINI, Simone; WITKIN, Steven S.2023-01-01T00:00:00ZImmunoglobulin A Antibodies Against Myelin Oligodendrocyte Glycoprotein in a Subgroup of Patients With Central Nervous System DemyelinationGOMES, Ana Beatriz Ayroza Galvao RibeiroKULSVEHAGEN, LailaLIPPS, PatrickCAGOL, AlessandroCERDA-FUERTES, NuriaNEZIRAJ, TraditeFLAMMER, JuliaLERNER, JasmineLECOURT, Anne-CatherineSIEBENBORN, Nina De Oliveira S.CORTESE, RosaSCHAEDELIN, SabineSCHOEPS, Vinicius AndreoliMATOS, Aline de Moura BrasilMENDES, Natalia TrombiniPEREIRA, Clarissa dos ReisMONTEIRO, Mario Luiz RibeiroAPOSTOLOS-PEREIRA, Samira Luisa dosSCHINDLER, PatrickCHIEN, ClaudiaSCHWAKE, CarolinSCHNEIDER, RuthPAKEERATHAN, ThivyaAKTAS, OrhanFISCHER, UrsMEHLING, MatthiasDERFUSS, TobiasKAPPOS, LudwigAYZENBERG, IlyaRINGELSTEIN, MariusPAUL, FriedemannCALLEGARO, DagobertoKUHLE, JensPAPADOPOULOU, AthinaGRANZIERA, CristinaPROBSTEL, Anne-Katrinhttps://observatorio.fm.usp.br/handle/OPI/574622024-03-06T06:07:45Z2023-01-01T00:00:00ZTitle: Immunoglobulin A Antibodies Against Myelin Oligodendrocyte Glycoprotein in a Subgroup of Patients With Central Nervous System Demyelination
Authors: GOMES, Ana Beatriz Ayroza Galvao Ribeiro; KULSVEHAGEN, Laila; LIPPS, Patrick; CAGOL, Alessandro; CERDA-FUERTES, Nuria; NEZIRAJ, Tradite; FLAMMER, Julia; LERNER, Jasmine; LECOURT, Anne-Catherine; SIEBENBORN, Nina De Oliveira S.; CORTESE, Rosa; SCHAEDELIN, Sabine; SCHOEPS, Vinicius Andreoli; MATOS, Aline de Moura Brasil; MENDES, Natalia Trombini; PEREIRA, Clarissa dos Reis; MONTEIRO, Mario Luiz Ribeiro; APOSTOLOS-PEREIRA, Samira Luisa dos; SCHINDLER, Patrick; CHIEN, Claudia; SCHWAKE, Carolin; SCHNEIDER, Ruth; PAKEERATHAN, Thivya; AKTAS, Orhan; FISCHER, Urs; MEHLING, Matthias; DERFUSS, Tobias; KAPPOS, Ludwig; AYZENBERG, Ilya; RINGELSTEIN, Marius; PAUL, Friedemann; CALLEGARO, Dagoberto; KUHLE, Jens; PAPADOPOULOU, Athina; GRANZIERA, Cristina; PROBSTEL, Anne-Katrin
Abstract: IMPORTANCE Differential diagnosis of patients with seronegative demyelinating central nervous system (CNS) disease is challenging. In this regard, evidence suggests that immunoglobulin (Ig) A plays a role in the pathogenesis of different autoimmune diseases. Yet little is known about the presence and clinical relevance of IgA antibodies against myelin oligodendrocyte glycoprotein (MOG) in CNS demyelination. OBJECTIVE To investigate the frequency of MOG-IgA and associated clinical features in patients with demyelinating CNS disease and healthy controls. DESIGN, SETTING, AND PARTICIPANTS This longitudinal study comprised 1 discovery and 1 confirmation cohort derived from 5 centers. Participants included patients with suspected or confirmed demyelinating diseases and healthy controls. MOG-IgA, MOG-IgG, and MOG-IgM were measured in serum samples and cerebrospinal fluid (CSF) of patients, who were assessed from September 2012 to April 2022. MAIN OUTCOMES AND MEASURES Frequency and clinical features of patients who were seropositive for MOG-IgA and double-seronegative for aquaporin 4 (AQP4) IgG and MOG-IgG. RESULTS After the exclusion of 5 participants with coexisting AQP4-IgG and MOG-IgA, MOG-IgG, and/or MOG-IgM, 1339 patients and 110 healthy controls were included; the median follow-up time was 39 months (range, 0-227 months). Of included patients with isolated MOG-IgA, 11 of 18 were female (61%), and the median age was 31.5 years (range, 3-76 years). Among patients double-seronegative for AQP4-IgG and MOG-IgG (1126/1339; 84%), isolated MOG-IgA was identified in 3 of 50 patients (6%) with neuromyelitis optica spectrum disorder, 5 of 228 patients (2%) with other CNS demyelinating diseases, and 10 of 848 patients (1%) with multiple sclerosis but in none of the healthy controls (0/110). The most common disease manifestation in patients seropositive for isolated MOG-IgA was myelitis (11/17 [65%]), followed by more frequent brainstem syndrome (7/16 [44%] vs 14/75 [19%], respectively; P =.048), and infrequent manifestation of optic neuritis (4/15 [27%] vs 46/73 [63%], respectively; P =.02) vs patients with MOG-IgG. Among patients fulfilling 2017 McDonald criteria for multiple sclerosis, MOG-IgA was associated with less frequent CSF-specific oligoclonal bands (4/9 [44%] vs 325/351 [93%], respectively; P <.001) vs patients with multiple sclerosis who were MOG-IgG/IgA seronegative. Further, most patients with isolated MOG-IgA presented clinical attacks after recent infection or vaccination (7/11 [64%]). CONCLUSION AND RELEVANCE In this study, MOG-specific IgA was identified in a subgroup of patients who were double-seronegative for AQP4-/MOG-IgG, suggesting that MOG-IgA may be a novel diagnostic biomarker for patients with CNS demyelination.2023-01-01T00:00:00Z