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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | CAPPI, Carolina | - |
dc.contributor.author | MUNIZ, Renan Kawano | - |
dc.contributor.author | SAMPAIO, Aline Santos | - |
dc.contributor.author | CORDEIRO, Quirino | - |
dc.contributor.author | BRENTANI, Helena | - |
dc.contributor.author | PALACIOS, Selma A. | - |
dc.contributor.author | MARQUES, Andrea H. | - |
dc.contributor.author | VALLADA, Homero | - |
dc.contributor.author | MIGUEL, Euripedes Constantino | - |
dc.contributor.author | GUILHERME, Luiza | - |
dc.contributor.author | HOUNIE, Ana Gabriela | - |
dc.date.accessioned | 2013-07-30T15:18:57Z | - |
dc.date.available | 2013-07-30T15:18:57Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | ARQUIVOS DE NEURO-PSIQUIATRIA, v.70, n.2, p.87-90, 2012 | - |
dc.identifier.issn | 0004-282X | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/1092 | - |
dc.description.abstract | Obsessive-compulsive disorder (OCD) is a prevalent psychiatric disorder of unknown etiology. However, there is some evidence that the immune system may play an important role in its pathogenesis. In the present study, two polymorphisms (rs1800795 and rs361525) in the promoter region of the cytokine tumor necrosis factor-alpha (TNFA) gene were genotyped in 183 OCD patients and in 249 healthy controls. The statistical tests were performed using the PLINK (R) software. We found that the A allele of the TNFA rs361525 polymorphism was significantly associated with OCD subjects, according to the allelic x association test (p=0.007). The presence of genetic markers, such as inflammatory cytokines genes linked to OCD, may represent additional evidence supporting the rote of the immune system in its pathogenesis. | - |
dc.description.abstract | O transtorno obsessivo-compulsivo (TOC) é um quadro psiquiátrico de prevalência considerável na população e de etiologia desconhecida. No entanto, há evidências de que o sistema imunológico pode desempenhar um papel importante em sua patogênese. No presente estudo, dois polimorfismos (rs1800795 e rs361525), localizados na região promotora do gene que codifica a citocina conhecida como fator de necrose tumoral alfa (TNFA), foram genotipados em 183 pacientes com TOC e 249 controles saudáveis. Os testes estatísticos foram realizados utilizando-se o software PLINK®. Assim, evidenciou-se que o alelo A do polimorfismo rs361525 apresentava associação estatisticamente significante com o TOC (p=0,007). A presença de marcadores genéticos, tais como genes que codificam citocinas inflamatórias, associados com TOC, confere suporte adicional ao papel do sistema imunológico na patogênese desse transtorno. | - |
dc.description.sponsorship | CAPES/PRODOC | - |
dc.description.sponsorship | FAPESP [98/15-013-9, 2005/55628-8] | - |
dc.description.sponsorship | CNPq | - |
dc.language.iso | eng | - |
dc.publisher | ASSOC ARQUIVOS NEURO- PSIQUIATRIA | - |
dc.relation.ispartof | Arquivos de Neuro-Psiquiatria | - |
dc.rights | openAccess | - |
dc.subject | cytokines | - |
dc.subject | genetic markers | - |
dc.subject | mental disorder | - |
dc.subject | polymorphism | - |
dc.subject | citocinas | - |
dc.subject | marcadores genéticos | - |
dc.subject | transtorno mental | - |
dc.subject | polimorfismo | - |
dc.subject.other | necrosis-factor-alpha | - |
dc.subject.other | promoter polymorphism | - |
dc.subject.other | depressive symptoms | - |
dc.subject.other | rheumatic-fever | - |
dc.subject.other | stress | - |
dc.subject.other | brain | - |
dc.subject.other | identification | - |
dc.subject.other | epidemiology | - |
dc.subject.other | population | - |
dc.subject.other | mechanisms | - |
dc.title | Association study between functional polymorphisms in the TNF-alpha gene and obsessive-compulsive disorder | - |
dc.title.alternative | Estudo de associação entre polimorfismos funcionais do gene do TNF-alfa e transtorno obsessivo-compulsivo | - |
dc.type | article | - |
dc.rights.holder | Copyright ASSOC ARQUIVOS NEURO- PSIQUIATRIA | - |
dc.identifier.doi | 10.1590/S0004-282X2012000200003 | - |
dc.identifier.pmid | 22311210 | - |
dc.subject.wos | Neurosciences | - |
dc.subject.wos | Psychiatry | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | CORDEIRO, Quirino:Santa Casa Med Sch, Dept Psychiat & Psychol Med, Sao Paulo, Brazil | - |
hcfmusp.description.beginpage | 87 | - |
hcfmusp.description.endpage | 90 | - |
hcfmusp.description.issue | 2 | - |
hcfmusp.description.volume | 70 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84857136589 | - |
hcfmusp.origem.id | WOS:000300650300003 | - |
hcfmusp.origem.id | SCIELO:S0004-282X2012000200003 | - |
hcfmusp.publisher.city | SAO PAULO SP | - |
hcfmusp.publisher.country | BRAZIL | - |
hcfmusp.relation.reference | Abraham LJ, 1999, J LEUKOCYTE BIOL, V66, P562 | - |
hcfmusp.relation.reference | Bayley JP, 2001, CYTOKINE, V14, P316, DOI 10.1006/cyto.2001.0902 | - |
hcfmusp.relation.reference | Brinkman B M, 1995, J Inflamm, V46, P32 | - |
hcfmusp.relation.reference | Cordeiro Q, 2009, REV BRAS PSIQUIATR, V31, P131 | - |
hcfmusp.relation.reference | DROUET C, 1991, J IMMUNOL, V147, P1694 | - |
hcfmusp.relation.reference | FONG CLW, 1994, NUCLEIC ACIDS RES, V22, P1108, DOI 10.1093/nar/22.6.1108 | - |
hcfmusp.relation.reference | Garcia-Bueno B, 2008, NEUROSCI BIOBEHAV R, V32, P1136, DOI 10.1016/j.neubiorev.2008.04.001 | - |
hcfmusp.relation.reference | Hettema JM, 2001, AM J PSYCHIAT, V158, P1568, DOI 10.1176/appi.ajp.158.10.1568 | - |
hcfmusp.relation.reference | Hounie AG, 2008, NEUROSCI LETT, V442, P86, DOI 10.1016/j.neulet.2008.07.022 | - |
hcfmusp.relation.reference | Jun TY, 2003, PSYCHIAT GENET, V13, P179, DOI 10.1097/01.ypg.0000066962.66429.49 | - |
hcfmusp.relation.reference | Kaluza W, 2000, J INVEST DERMATOL, V114, P1180, DOI 10.1046/j.1523-1747.2000.00001.x | - |
hcfmusp.relation.reference | Kohl C, 2007, CURR DRUG METAB, V8, P283, DOI 10.2174/138920007780362572 | - |
hcfmusp.relation.reference | Konuk N, 2007, MEDIAT INFLAMM, V2007, P1 | - |
hcfmusp.relation.reference | Licinio J, 1999, MOL PSYCHIATR, V4, P317, DOI 10.1038/sj.mp.4000586 | - |
hcfmusp.relation.reference | Maes M, BIOL PSYCHIAT, V45, P833 | - |
hcfmusp.relation.reference | McEwen BS, 2007, PHYSIOL REV, V87, P873, DOI 10.1152/physrev.00041.2006 | - |
hcfmusp.relation.reference | Miguel EC, 2008, REV BRAS PSIQUIATR, V30, P185 | - |
hcfmusp.relation.reference | Miller AH, 2009, BRAIN BEHAV IMMUN, V23, P149, DOI 10.1016/j.bbi.2008.08.006 | - |
hcfmusp.relation.reference | MOSSNER, 2007, WORLD J BIOL PSYCHIA, V8, P141 | - |
hcfmusp.relation.reference | POCIOT F, 1995, SCAND J IMMUNOL, V42, P501, DOI 10.1111/j.1365-3083.1995.tb03686.x | - |
hcfmusp.relation.reference | Purcell S, 2007, AM J HUM GENET, V81, P559, DOI 10.1086/519795 | - |
hcfmusp.relation.reference | Ramasawmy R, 2007, MOL IMMUNOL, V44, P1873, DOI 10.1016/j.molimm.2006.10.001 | - |
hcfmusp.relation.reference | Sallakci N, 2005, J AUTOIMMUN, V25, P150, DOI 10.1016/j.jaut.2005.05.005 | - |
hcfmusp.relation.reference | SAWADA M, 2006, J NEURAL TRANSM, V70, P373 | - |
hcfmusp.relation.reference | Silverman MN, 2005, VIRAL IMMUNOL, V18, P41, DOI 10.1089/vim.2005.18.41 | - |
hcfmusp.relation.reference | Szelenyi J, 2007, ANN NY ACAD SCI, V1113, P311, DOI 10.1196/annals.1391.026 | - |
hcfmusp.relation.reference | Uglialoro AM, 1998, TISSUE ANTIGENS, V52, P359, DOI 10.1111/j.1399-0039.1998.tb03056.x | - |
hcfmusp.relation.reference | VASSALLI P, 1992, ANNU REV IMMUNOL, V10, P411, DOI 10.1146/annurev.immunol.10.1.411 | - |
hcfmusp.relation.reference | WEISSMAN MM, 1994, J CLIN PSYCHIAT, V55, P5 | - |
hcfmusp.relation.reference | Westendorp RGJ, 1997, LANCET, V349, P1912, DOI 10.1016/S0140-6736(05)63910-4 | - |
dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | CAPES | - |
hcfmusp.remissive.sponsorship | CNPq | - |
hcfmusp.remissive.sponsorship | FAPESP | - |
hcfmusp.lim.ref | 2012 | - |
hcfmusp.citation.scopus | 24 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPS Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - HC/IPq Artigos e Materiais de Revistas Científicas - LIM/19 Artigos e Materiais de Revistas Científicas - LIM/21 Artigos e Materiais de Revistas Científicas - LIM/23 |
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