Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis
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Citações na Scopus
25
Tipo de produção
article
Data de publicação
2015
Editora
ASSOC BRASILEIRA OTORRINOLARINGOLOGIA & CIRURGIA CERVICOFACIAL
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Citação
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY, v.81, n.3, p.248-254, 2015
Resumo
Introduction: Elective neck dissection is recommended in cases of oral cavity squamous cell carcinoma without lymph node metastasis because of the risk of occult metastasis. Objective: The present study aimed to evaluate predictive factors for occult lymph node metastasis in patients with oral cavity squamous cell carcinoma treated with elective neck dissection and their impact on overall and disease-free survival. Methods: Forty surgically treated patients were retrospectively included. Results: Ten cases (25%) had lymphatic metastasis. Of the studied variables, perineural and angiolymphatic invasion in addition to tumor thickness were statistically associated with lymph node metastasis. Only angiolymphatic invasion was identified as an independent risk factor for occult metastasis in the logistic regression (OR=39.3; p=0.002). There was no association between overall and disease-free survival with the presence of occult lymph node metastasis. Conclusion: Metastatic disease rate was similar to that found in the literature. Perineural and angiolymphatic invasion and tumor thickness were associated with occult metastasis, but only angiolymphatic invasion showed to be an independent risk factor (C) 2015 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial.
Palavras-chave
Carcinoma, Squamous cell, Mouth, Lymphatic metastasis, Prognosis
Referências
- Alkureishi LWT, 2010, ANN SURG ONCOL, V17, P2459, DOI 10.1245/s10434-010-1111-3
- Amaral TMP, 2004, ORAL ONCOL, V40, P780, DOI 10.1016/j.oraloncology.2003.10.009
- Byers RM, 1998, HEAD NECK-J SCI SPEC, V20, P138, DOI 10.1002/(SICI)1097-0347(199803)20:2<138::AID-HED7>3.0.CO;2-3
- DAVIDSON BJ, 1993, AM J SURG, V166, P395, DOI 10.1016/S0002-9610(05)80340-X
- El-Naaj Imad Abu, 2011, J Oral Maxillofac Surg, V69, P2674, DOI 10.1016/j.joms.2011.02.012
- FAKIH AR, 1989, SEMIN SURG ONCOL, V5, P327, DOI 10.1002/ssu.2980050507
- Fasunla AJ, 2011, ORAL ONCOL, V47, P320, DOI 10.1016/j.oraloncology.2011.03.009
- Ferlito A, 2009, BRIT J ORAL MAX SURG, V47, P5, DOI 10.1016/j.bjoms.2008.06.001
- Fukano H, 1997, HEAD NECK-J SCI SPEC, V19, P205, DOI 10.1002/(SICI)1097-0347(199705)19:3<205::AID-HED7>3.0.CO;2-6
- Genden EM, 2010, EUR ARCH OTO-RHINO-L, V267, P1001, DOI 10.1007/s00405-010-1206-2
- Goshen E, 2006, INT J ORAL MAX SURG, V35, P332, DOI 10.1016/j.ijom.2005.08.003
- Govers TM, 2013, ORAL ONCOL, V49, P726, DOI 10.1016/j.oraloncology.2013.04.006
- Huang SH, 2009, CANCER, V115, P1489, DOI 10.1002/cncr.24161
- JERJES W, 2010, HEAD NECK ONCOL, V20, P2
- Kelner N, 2014, BR J MAXILLOFAC SURG
- KLIGERMAN J, 1994, AM J SURG, V168, P391, DOI 10.1016/S0002-9610(05)80082-0
- Kowalski L P, 2007, Acta Otorhinolaryngol Ital, V27, P113
- Lim YC, 2004, EJSO, V30, P692, DOI 10.1016/j.ejso.2004.02.001
- Martinez-Gimeno C, 1995, LARYNGOSCOPE, V105, P728
- Melkane AE, 2012, LARYNGOSCOPE, V122, P1782, DOI 10.1002/lary.23383
- MORTON RP, 1994, ARCH OTOLARYNGOL, V120, P717
- Nieuwenhuis EJC, 2002, HEAD NECK-J SCI SPEC, V24, P282, DOI 10.1002/hed.10018
- Paleri V, 2005, HEAD NECK-J SCI SPEC, V27, P739, DOI 10.1002/hed.20228
- Pinto FR, 2012, REV BRAS CIR CABECA, V41, P53
- Pinto FR, 2013, EUR ARCH OTO-RHINO-L, V271, P1747
- Poonacha TK, 2011, J CLIN ONCOL, V29, P186, DOI 10.1200/JCO.2010.31.6414
- SHAH JP, 1990, CANCER, V66, P109, DOI 10.1002/1097-0142(19900701)66:1<109::AID-CNCR2820660120>3.0.CO;2-A
- VANDENBROUCK C, 1980, CANCER, V46, P386, DOI 10.1002/1097-0142(19800715)46:2<386::AID-CNCR2820460229>3.0.CO;2-9
- Vijayakumar Manavalan, 2011, Indian J Surg Oncol, V2, P172, DOI 10.1007/s13193-011-0083-5
- Woolgar JA, 1997, INT J ORAL MAX SURG, V26, P3, DOI 10.1016/S0901-5027(97)80837-5
- Yu SB, 2006, AM J SURG, V191, P94, DOI 10.1016/j.amjsurg.2005.10.008