Septic Shock in Advanced Age: Transcriptome Analysis Reveals Altered Molecular Signatures in Neutrophil Granulocytes

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art_PELLEGRINA_Septic_Shock_in_Advanced_Age_Transcriptome_Analysis_Reveals_2015.PDF (431.58 KB)
Citações na Scopus
27
Tipo de produção
article
Data de publicação
2015
Editora
PUBLIC LIBRARY SCIENCE
DOI
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Scopus
Web of Science
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ISSN da Revista
Título do Volume
Autores
PELLEGRINA, Diogo Vieira da Silva
SEVERINO, Patricia
ANDREGHETTO, Flavia Maziero
REIS, Eduardo Moraes
Autor de Grupo de pesquisa
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Citação
PLOS ONE, v.10, n.6, article ID e0128341, 16p, 2015
Projetos de Pesquisa
Unidades Organizacionais
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Resumo
Sepsis is one of the highest causes of mortality in hospitalized people and a common complication in both surgical and clinical patients admitted to hospital for non-infectious reasons. Sepsis is especially common in older people and its incidence is likely to increase substantially as a population ages. Despite its increased prevalence and mortality in older people, immune responses in the elderly during septic shock appear similar to that in younger patients. The purpose of this study was to conduct a genome-wide gene expression analysis of circulating neutrophils from old and young septic patients to better understand how aged individuals respond to severe infectious insult. We detected several genes whose expression could be used to differentiate immune responses of the elderly from those of young people, including genes related to oxidative phosphorylation, mitochondrial dysfunction and TGF-a signaling, among others. Our results identify major molecular pathways that are particularly affected in the elderly during sepsis, which might have a pivotal role in worsening clinical outcomes compared with young people with sepsis.
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URI
https://observatorio.fm.usp.br/handle/OPI/11559
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/51