Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/11636
Title: Trichosporon inkin as an Emergent Pathogen in Patients With Severe Pemphigus
Authors: ALMEIDA JUNIOR, Joao Nobrega deOLIVEIRA, Renata Buccheri deDUARTE, AmaroMOTTA, Adriana LopesROSSI, FlaviaFIGUEIREDO, Dulce Sachiko Yamamoto deNEGRO, Gilda Maria Barbaro DelAOKI, ValeriaMARUTA, Celina WakisakaSANTI, Claudia GiuliBENARD, Gil
Citation: JAMA DERMATOLOGY, v.151, n.6, p.642-645, 2015
Abstract: IMPORTANCE To our knowledge, these are the first reports of bloodstream infections by Trichosporon inkin in patients with pemphigus. OBSERVATIONS Trichosporon inkin, a novel organism causing bloodstream infection, was detected in 2 patients with pemphigus. An elderly man with pemphigus foliaceus died despite treatment with liposomal amphotericin B, 3mg/kg/d, and a young girl with pemphigus vulgaris responded to treatment with voriconazole, 8mg/kg/d, for 24 days. One of the T inkin isolates had a minimal inhibitory concentration of 2mg/L against amphotericin B, suggesting resistance to the drug. CONCLUSIONS AND RELEVANCE Delayed suspicion of invasive infection by T inkin may result in a poor outcome in patients with severe forms of pemphigus. This opportunistic infection is highly refractory to conventional potent antifungal treatment.
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Artigos e Materiais de Revistas Científicas - FM/MDT
Departamento de Dermatologia - FM/MDT

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/03
LIM/03 - Laboratório de Medicina Laboratorial

Artigos e Materiais de Revistas Científicas - LIM/53
LIM/53 - Laboratório de Micologia

Artigos e Materiais de Revistas Científicas - LIM/56
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências


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