Effects of Duodenal-Jejunal Bypass Liner (EndoBarrierA (R)) on Gastric Emptying in Obese and Type 2 Diabetic Patients

Imagem de Miniatura
Arquivos
art_MOURA_Effects_of_DuodenalJejunal_Bypass_Liner_EndoBarrierA_R_on_2015.PDF (1.12 MB)
Citações na Scopus
35
Tipo de produção
article
Data de publicação
2015
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER
Autores
OLIVEIRA, Suzana Lopes de
GALVAO-NETO, Manoel dos Passos
Citação
OBESITY SURGERY, v.25, n.9, p.1618-1625, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The duodenal-jejunal bypass liner (DJBL) is a promising technique for treating obesity and type 2 diabetes mellitus (T2DM). However, despite promising results, its mechanism of action has not been elucidated. It is thought to promote changes in gastric emptying owing to the neuro-endocrine axis. The aim of this paper was to study DJBL-induced changes in gastric emptying and the relationship of those changes with weight loss and T2DM. Twenty-five patients with obesity and T2DM met inclusion criteria. Scintigraphic gastric emptying testing was performed prior to implantation, 16 weeks after implantation, and 4 weeks after removal. The average gastric retention was compared between tests, to examine the relationship between gastric emptying and those who lost more than 10 % of total body weight. Similarly, we compared average gastric retention between those who achieved a glycated hemoglobin target lower than 7 %. Average gastric retention was greater after DJBL implantation compared with the baseline (first hour, 74 +/- 16.3 %, p = 0.001; second hour, 45 +/- 25 %, p < 0.001; fourth hour, 15.8 +/- 15 %, p < 0.001). There was no difference between the baseline and 4 weeks after device removal (fourth hour, p = 0.057). Gastric retention was similar between patients who achieved T2DM control and those who did not (p = 0.73). Additionally, no difference was seen between patients who lost more than 10 % of body weight and those who did not (p = 0.275). DJBL delays gastric emptying but is reversible after withdrawal. The changes in gastric emptying have no relationship to weight loss and T2DM control.
Palavras-chave
Gastric emptying, Endoscopy, Diabetes mellitus, Type 2/radionuclide imaging, Obesity, Duodenum/surgery
URI
https://observatorio.fm.usp.br/handle/OPI/11666
Referências
  1. Abell TL, 2008, AM J GASTROENTEROL, V103, P753, DOI 10.1111/j.1572-0241.2007.01636.x
  2. Allison DB, 1999, AM J PUBLIC HEALTH, V89, P1194, DOI 10.2105/AJPH.89.8.1194
  3. DEPONTI F, 1987, AM J PHYSIOL, V252, pG595
  4. AZPIROZ F, 1990, GASTROENTEROLOGY, V98, P1193
  5. Cohen RV, 2013, J CLIN ENDOCR METAB, V98, pE279, DOI 10.1210/jc.2012-2814
  6. de Jonge C, 2013, OBES SURG, V23, P1354, DOI 10.1007/s11695-013-0921-3
  7. Dockray GJ, 2012, CURR OPIN ENDOCRINOL, V19, P8, DOI 10.1097/MED.0b013e32834eb77d
  8. Escalona A, 2010, SURG OBES RELAT DIS, V6, P126, DOI 10.1016/j.soard.2009.12.009
  9. Escalona A, 2012, ANN SURG, V255, P1080, DOI 10.1097/SLA.0b013e31825498c4
  10. Flum DR, 2004, J AM COLL SURGEONS, V199, P543, DOI 10.1016/j.jamcollsurg.2004.06.014
  11. Gersin KS, 2007, SURG INNOV, V14, P275, DOI 10.1177/1553350607312901
  12. Guh DP, 2009, BMC PUBLIC HEALTH, V9, P1
  13. Guyton A, 2006, TXB MED PHYSL, V11th, P771
  14. Hellstrom PM, 2001, PHYSIOL BEHAV, V74, P735, DOI 10.1016/S0031-9384(01)00618-7
  15. Hellström Per M, 2006, Best Pract Res Clin Anaesthesiol, V20, P397, DOI 10.1016/j.bpa.2006.02.002
  16. Levine A, 2009, SURG OBES RELAT DIS, V5, P371, DOI 10.1016/j.soard.2009.02.010
  17. Lopasso FP, 2008, J CLIN GASTROENTEROL, V42, P48
  18. Martins BC, 2012, DIABETES TECHNOL THE, V14
  19. Moura EGH, 2012, J GASTROENTEROL DI S, VS2, P003
  20. Munoz R, 2014, CURR CARDIOL REP, V16, DOI 10.1007/s11886-013-0454-3
  21. Rohde U, 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2013-003417
  22. Rubino F, 2006, ANN SURG, V244, P741, DOI 10.1097/01.sla.0000224726.61448.1b
  23. SAID G, 1992, NEW ENGL J MED, V326, P1257, DOI 10.1056/NEJM199205073261905
  24. Waseem S, 2009, WORLD J GASTROENTERO, V15, P25, DOI 10.3748/wjg.15.25
  25. Tarnoff M, 2009, SURG ENDOSC, V23, P650, DOI 10.1007/s00464-008-0125-4
  26. TOUGAS G, 2000, GASTROENTEROLOGY, V95, P1456
  27. Ueno H, 2008, REGUL PEPTIDES, V145, P12, DOI 10.1016/j.regpep.2007.09.011
  28. World Health Organization, 2012, WORLD HLTH STAT SNAP

Coleções
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/35
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