https://observatorio.fm.usp.br/handle/OPI/11666
Title: | Effects of Duodenal-Jejunal Bypass Liner (EndoBarrierA (R)) on Gastric Emptying in Obese and Type 2 Diabetic Patients |
Authors: | MOURA, Eduardo Guimaraes Hourneaux de; LOPES, Guilherme Sauniti; MARTINS, Bruno da Costa; ORSO, Ivan Roberto Bonotto; COUTINHO, Artur Martins Novaes; OLIVEIRA, Suzana Lopes de; SAKAI, Paulo; GALVAO-NETO, Manoel dos Passos; SANTO, Marco Aurelio; SAPIENZA, Marcelo Tatit; CECCONELLO, Ivan; BUCHPIGUEL, Carlos Alberto |
Citation: | OBESITY SURGERY, v.25, n.9, p.1618-1625, 2015 |
Abstract: | The duodenal-jejunal bypass liner (DJBL) is a promising technique for treating obesity and type 2 diabetes mellitus (T2DM). However, despite promising results, its mechanism of action has not been elucidated. It is thought to promote changes in gastric emptying owing to the neuro-endocrine axis. The aim of this paper was to study DJBL-induced changes in gastric emptying and the relationship of those changes with weight loss and T2DM. Twenty-five patients with obesity and T2DM met inclusion criteria. Scintigraphic gastric emptying testing was performed prior to implantation, 16 weeks after implantation, and 4 weeks after removal. The average gastric retention was compared between tests, to examine the relationship between gastric emptying and those who lost more than 10 % of total body weight. Similarly, we compared average gastric retention between those who achieved a glycated hemoglobin target lower than 7 %. Average gastric retention was greater after DJBL implantation compared with the baseline (first hour, 74 +/- 16.3 %, p = 0.001; second hour, 45 +/- 25 %, p < 0.001; fourth hour, 15.8 +/- 15 %, p < 0.001). There was no difference between the baseline and 4 weeks after device removal (fourth hour, p = 0.057). Gastric retention was similar between patients who achieved T2DM control and those who did not (p = 0.73). Additionally, no difference was seen between patients who lost more than 10 % of body weight and those who did not (p = 0.275). DJBL delays gastric emptying but is reversible after withdrawal. The changes in gastric emptying have no relationship to weight loss and T2DM control. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MDR Artigos e Materiais de Revistas Científicas - FM/MGT Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/35 Artigos e Materiais de Revistas Científicas - LIM/43 Artigos e Materiais de Revistas Científicas - ODS/03 |
File | Description | Size | Format | |
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art_MOURA_Effects_of_DuodenalJejunal_Bypass_Liner_EndoBarrierA_R_on_2015.PDF Restricted Access | publishedVersion (English) | 1.14 MB | Adobe PDF | View/Open Request a copy |
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