Community Structure Analysis of Transcriptional Networks Reveals Distinct Molecular Pathways for Early- and Late-Onset Temporal Lobe Epilepsy with Childhood Febrile Seizures

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP MOREIRA-FILHO, Carlos Alberto FMUSP-HC
BERTONHA, Fernanda Bernardi FMUSP-HC
SILVA, Filipi Nascimento
COSTA, Luciano da Fontoura
SILVA, Alexandre Valotta FMUSP-HC
CASTRO, Luiz Henrique Martins FMUSP-HC
WEN, Hung-Tzu FMUSP-HC 2015
dc.identifier.citation PLOS ONE, v.10, n.5, article ID UNSP e0128174, 37p, 2015
dc.identifier.issn 1932-6203
dc.description.abstract Age at epilepsy onset has a broad impact on brain plasticity and epilepsy pathomechanisms. Prolonged febrile seizures in early childhood (FS) constitute an initial precipitating insult (IPI) commonly associated with mesial temporal lobe epilepsy (MTLE). FS-MTLE patients may have early disease onset, i.e. just after the IPI, in early childhood, or late-onset, ranging from mid-adolescence to early adult life. The mechanisms governing early (E) or late (L) disease onset are largely unknown. In order to unveil the molecular pathways underlying E and L subtypes of FS-MTLE we investigated global gene expression in hippocampal CA3 explants of FS-MTLE patients submitted to hippocampectomy. Gene coexpression networks (GCNs) were obtained for the E and L patient groups. A network-based approach for GCN analysis was employed allowing: i) the visualization and analysis of differentially expressed (DE) and complete (CO) - all valid GO annotated transcripts - GCNs for the E and L groups; ii) the study of interactions between all the system's constituents based on community detection and coarse-grained community structure methods. We found that the E-DE communities with strongest connection weights harbor highly connected genes mainly related to neural excitability and febrile seizures, whereas in L-DE communities these genes are not only involved in network excitability but also playing roles in other epilepsy-related processes. Inversely, in E-CO the strongly connected communities are related to compensatory pathways (seizure inhibition, neuronal survival and responses to stress conditions) while in L-CO these communities harbor several genes related to pro-epileptic effects, seizure-related mechanisms and vulnerability to epilepsy. These results fit the concept, based on fMRI and behavioral studies, that early onset epilepsies, although impacting more severely the hippocampus, are associated to compensatory mechanisms, while in late MTLE development the brain is less able to generate adaptive mechanisms, what has implications for epilepsy management and drug discovery.
dc.description.sponsorship · Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2009/53443-1, 2005/56446-0]
· Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [305635/2009-3]
· FAPESP [2005/00587-5, 2011/50761-2]
· CNPq [307333/2013-2]
· Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
· FAPESP-MCT/CNPq/PRONEX [2011/50761-2]
dc.language.iso eng
dc.relation.ispartof Plos One
dc.rights openAccess
dc.subject.other bone morphogenetic protein; long-term potentiation; factor-kappa-b; status epilepticus; complex networks; oxidative stress; gene-expression; hippocampal sclerosis; calcium-channels; nervous-system
dc.title Community Structure Analysis of Transcriptional Networks Reveals Distinct Molecular Pathways for Early- and Late-Onset Temporal Lobe Epilepsy with Childhood Febrile Seizures
dc.type article
dc.rights.holder Copyright PUBLIC LIBRARY SCIENCE LIM/36 LIM/45
dc.identifier.doi 10.1371/journal.pone.0128174
dc.identifier.pmid 26011637
dc.type.category original article
dc.type.version publishedVersion MOREIRA-FILHO, Carlos Alberto:FM:MPE BANDO, Silvia Yumi:FM:MPE BERTONHA, Fernanda Bernardi:FM:MPE IAMASHITA, Priscila:FM: SILVA, Alexandre Valotta:FM: CASTRO, Luiz Henrique Martins:FM:MNE WEN, Hung-Tzu:HC:ICHC · SILVA, Filipi Nascimento:Univ Sao Paulo, Inst Fis Sao Carlos, Sao Carlos, SP, Brazil
· COSTA, Luciano da Fontoura:Univ Sao Paulo, Inst Fis Sao Carlos, Sao Carlos, SP, Brazil WOS:000355183900201 2-s2.0-84930644912 SAN FRANCISCO USA
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