Community Structure Analysis of Transcriptional Networks Reveals Distinct Molecular Pathways for Early- and Late-Onset Temporal Lobe Epilepsy with Childhood Febrile Seizures

Show simple item record

dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author MOREIRA-FILHO, Carlos Alberto FMUSP-HC
BANDO, Silvia Yumi FMUSP-HC
BERTONHA, Fernanda Bernardi FMUSP-HC
IAMASHITA, Priscila FMUSP-HC
SILVA, Filipi Nascimento
COSTA, Luciano da Fontoura
SILVA, Alexandre Valotta FMUSP-HC
CASTRO, Luiz Henrique Martins FMUSP-HC
WEN, Hung-Tzu FMUSP-HC
dc.date.issued 2015
dc.identifier.citation PLOS ONE, v.10, n.5, article ID UNSP e0128174, 37p, 2015
dc.identifier.issn 1932-6203
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/11755
dc.description.abstract Age at epilepsy onset has a broad impact on brain plasticity and epilepsy pathomechanisms. Prolonged febrile seizures in early childhood (FS) constitute an initial precipitating insult (IPI) commonly associated with mesial temporal lobe epilepsy (MTLE). FS-MTLE patients may have early disease onset, i.e. just after the IPI, in early childhood, or late-onset, ranging from mid-adolescence to early adult life. The mechanisms governing early (E) or late (L) disease onset are largely unknown. In order to unveil the molecular pathways underlying E and L subtypes of FS-MTLE we investigated global gene expression in hippocampal CA3 explants of FS-MTLE patients submitted to hippocampectomy. Gene coexpression networks (GCNs) were obtained for the E and L patient groups. A network-based approach for GCN analysis was employed allowing: i) the visualization and analysis of differentially expressed (DE) and complete (CO) - all valid GO annotated transcripts - GCNs for the E and L groups; ii) the study of interactions between all the system's constituents based on community detection and coarse-grained community structure methods. We found that the E-DE communities with strongest connection weights harbor highly connected genes mainly related to neural excitability and febrile seizures, whereas in L-DE communities these genes are not only involved in network excitability but also playing roles in other epilepsy-related processes. Inversely, in E-CO the strongly connected communities are related to compensatory pathways (seizure inhibition, neuronal survival and responses to stress conditions) while in L-CO these communities harbor several genes related to pro-epileptic effects, seizure-related mechanisms and vulnerability to epilepsy. These results fit the concept, based on fMRI and behavioral studies, that early onset epilepsies, although impacting more severely the hippocampus, are associated to compensatory mechanisms, while in late MTLE development the brain is less able to generate adaptive mechanisms, what has implications for epilepsy management and drug discovery.
dc.description.sponsorship · Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2009/53443-1, 2005/56446-0]
· Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [305635/2009-3]
· FAPESP [2005/00587-5, 2011/50761-2]
· CNPq [307333/2013-2]
· Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
· FAPESP-MCT/CNPq/PRONEX [2011/50761-2]
dc.language.iso eng
dc.publisher PUBLIC LIBRARY SCIENCE
dc.relation.ispartof Plos One
dc.rights openAccess
dc.subject.other bone morphogenetic protein; long-term potentiation; factor-kappa-b; status epilepticus; complex networks; oxidative stress; gene-expression; hippocampal sclerosis; calcium-channels; nervous-system
dc.title Community Structure Analysis of Transcriptional Networks Reveals Distinct Molecular Pathways for Early- and Late-Onset Temporal Lobe Epilepsy with Childhood Febrile Seizures
dc.type article
dc.rights.holder Copyright PUBLIC LIBRARY SCIENCE
dc.description.group LIM/36
dc.description.group LIM/45
dc.identifier.doi 10.1371/journal.pone.0128174
dc.identifier.pmid 26011637
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author MOREIRA-FILHO, Carlos Alberto:FM:MPE
hcfmusp.author BANDO, Silvia Yumi:FM:MPE
hcfmusp.author BERTONHA, Fernanda Bernardi:FM:MPE
hcfmusp.author IAMASHITA, Priscila:FM:
hcfmusp.author SILVA, Alexandre Valotta:FM:
hcfmusp.author CASTRO, Luiz Henrique Martins:FM:MNE
hcfmusp.author WEN, Hung-Tzu:HC:ICHC
hcfmusp.author.external · SILVA, Filipi Nascimento:Univ Sao Paulo, Inst Fis Sao Carlos, Sao Carlos, SP, Brazil
· COSTA, Luciano da Fontoura:Univ Sao Paulo, Inst Fis Sao Carlos, Sao Carlos, SP, Brazil
hcfmusp.origem.id WOS:000355183900201
hcfmusp.origem.id 2-s2.0-84930644912
hcfmusp.publisher.city SAN FRANCISCO
hcfmusp.publisher.country USA
hcfmusp.relation.reference · Ahmad S, 2010, SEMIN PEDIATR NEUROL, V17, P150, DOI 10.1016/j.spen.2010.06.004
· Alam H, 2011, MOL BIOL CELL, V22, P4068, DOI 10.1091/mbc.E10-08-0703
· Alegro MD, 2012, MAGN RESON MED, V68, P1647, DOI 10.1002/mrm.24174
· [Anonymous], 1960, HIPPOCAMPUS, V18, P460, DOI [10.1002/hipo.20409, DOI 10.1002/HIP0.20409]
· Arion D, 2006, NEUROBIOL DIS, V22, P374, DOI 10.1016/j.nbd.2005.12.012
· Aruga J, 2004, MOL CELL NEUROSCI, V26, P205, DOI 10.1016/j.mcn.2004.01.004
· Bai DM, 2014, NUCLEIC ACIDS RES, V42, P1799, DOI 10.1093/nar/gkt971
· Balosso S, 2013, EXP NEUROL, V247, P267, DOI 10.1016/j.expneurol.2013.05.010
· Bando SY, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0026268
· Bando SY, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0079913
· Barabasi AL, 1999, SCIENCE, V286, P509, DOI 10.1126/science.286.5439.509
· Barabasi AL, 2011, NAT REV GENET, V12, P56, DOI 10.1038/nrg2918
· Barabasi AL, 2004, NAT REV GENET, V5, P101, DOI 10.1038/nrg1272
· Barreau C, 2006, BIOCHIMIE, V88, P515, DOI 10.1016/j.biochi.2005.10.011
· Bartolini F, 2010, BBA-MOL CELL RES, V1803, P164, DOI 10.1016/j.bbamcr.2009.07.006
· Baulac M, 2015, REV NEUROL, V26
· Bernhardt BC, 2011, CEREB CORTEX, V21, P2147, DOI 10.1093/cercor/bhq291
· Bernhardt BC, 2013, FRONT HUM NEUROSCI, V7, DOI 10.3389/fnhum.2013.00624
· Bhanot K, 2011, J PROTEOME RES, V10, P5118, DOI 10.1021/pr200564g
· Bhargava S, 2014, MOL CELL BIOCHEM, V387, P55, DOI 10.1007/s11010-013-1869-2
· Bianchi MG, 2014, CELL MOL LIFE SCI, V71, P2001, DOI 10.1007/s00018-013-1484-0
· Bierhals T, 2013, EUR J MED GENET, V56, P325, DOI 10.1016/j.ejmg.2013.03.009
· Bilevicius E, 2010, NEUROLOGY, V75, P1695, DOI 10.1212/WNL.0b013e3181fc29dd
· Blondel VD, 2008, J STAT MECH-THEORY E, DOI 10.1088/1742-5468/2008/10/P10008
· Blumcke I, 2013, EPILEPSIA, V54, P1315, DOI 10.1111/epi.12220
· Bosio Y, 2012, EUR J CELL BIOL, V91, P662, DOI 10.1016/j.ejcb.2012.03.002
· BROCKMANN D, 2009, REV NONLINEAR DYNAMI, V2, P1
· Broomfield A, 2013, JIMD Rep, V11, P93, DOI 10.1007/8904_2013_227
· Buchser WJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0038101
· Burk K, 2013, INT J NEUROSCI, V123, P278, DOI 10.3109/00207454.2012.755180
· Cai JJ, 2010, GENOME BIOL EVOL, V2, P815, DOI 10.1093/gbe/evq064
· Cao GD, 2001, J NEUROSCI, V21, P4678
· Carpentier C, 2014, BBA-MOL BASIS DIS, V1842, P654, DOI 10.1016/j.bbadis.2014.01.004
· Casanova JR, 2013, EUR J NEUROSCI, V38, P3115, DOI 10.1111/ejn.12315
· Charong N, 2011, J CANCER RES CLIN, V137, P89, DOI 10.1007/s00432-010-0863-2
· Charytoniuk DA, 2000, NEUROSCIENCE, V100, P33, DOI 10.1016/S0306-4522(00)00246-3
· Chaussabel D, 2014, NAT REV IMMUNOL, V14, P271, DOI 10.1038/nri3642
· Chen ZL, 2003, MOL BIOL CELL, V14, P2665, DOI 10.1091/mbc.E02-12-0832
· Cheung ZH, 2004, NEUROSCI LETT, V361, P47, DOI 10.1016/j.neulet.2003.12.117
· Chiang S, 2014, CLIN NEUROPHYSIOL, V125, P1295, DOI 10.1016/j.clinph.2014.04.004
· Choudhary S, 2011, J BIOL CHEM, V286, P37187, DOI 10.1074/jbc.M111.224923
· Choy M, 2014, J NEUROSCI, V34, P8672, DOI 10.1523/JNEUROSCI.4806-13.2014
· Chungath M, 2008, NAT CLIN PRACT NEURO, V4, P610, DOI 10.1038/ncpneuro0922
· Clauset A, 2009, SIAM REV, V51, P661, DOI 10.1137/070710111
· Cloix JF, 2009, CURR MED CHEM, V16, P841
· Cornejo BJ, 2007, ANN NEUROL, V61, P411, DOI 10.1002/ana.21071
· Costa LD, 2011, ADV PHYS, V60, P329, DOI 10.1080/00018732.2011.572452
· Costa LD, 2008, PHYSICA A, V387, P6201, DOI 10.1016/j.physa.2008.06.034
· Costa LD, 2006, J STAT PHYS, V125, P845, DOI 10.1007/s10955-006-9130-y
· Coxon CH, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0049543
· Crepaldi L, 2013, PLOS GENET, V9, DOI 10.1371/journal.pgen.1003699
· da Fonseca ACC, 2014, FRONT CELL NEUROSCI, V8, DOI 10.3389/fncel.2014.00362
· Davies KG, 1996, EPILEPSY RES, V24, P119, DOI 10.1016/0920-1211(96)00008-3
· Devos SL, 2013, J NEUROSCI, V33, P12887, DOI 10.1523/JNEUROSCI.2107-13.2013
· Doucet G, 2013, HUM BRAIN MAPP, V34, P2202, DOI 10.1002/hbm.22059
· Doucet GE, 2015, BRAIN TOPOGR, V28, P113, DOI 10.1007/s10548-014-0366-6
· Du YS, 2013, BRAIN RES, V1509, P79, DOI 10.1016/j.brainres.2013.03.005
· Dube C, 2006, BRAIN, V129, P911, DOI 10.1093/brain/awl018
· Dube CM, 2009, BRAIN DEV-JPN, V31, P366, DOI 10.1016/j.braindev.2008.11.010
· El-Hattab AW, 2011, CLIN GENET, V79, P531, DOI 10.1111/j.1399-0004.2010.01496.x
· Erck C, 2005, P NATL ACAD SCI USA, V102, P7853, DOI 10.1073/pnas.0409626102
· Feliciano P, 2013, J NEUROSCI, V33, P18319, DOI 10.1523/JNEUROSCI.5293-12.2013
· Francis JS, 2011, GLIA, V59, P1435, DOI 10.1002/glia.21187
· Furukawa A, 2011, NEUROBIOL DIS, V43, P706, DOI 10.1016/j.nbd.2011.05.024
· Gasteier JE, 2005, EXP CELL RES, V306, P192, DOI 10.1016/j.yexer.2005.02.006
· Ghanta KS, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017135
· Glynn P, 2013, BBA-MOL CELL BIOL L, V1831, P633, DOI 10.1016/j.bbalip.2012.07.023
· Gomez-Ospina N, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0060526
· GRIFFIN WST, 1995, J NEUROCHEM, V65, P228
· Gunzel D, 2009, J CELL SCI, V122, P1507, DOI 10.1242/jcs.040113
· Hakimi MA, 2003, J BIOL CHEM, V278, P7234, DOI 10.1074/jbc.M208992200
· Halder SK, 2012, CELL MOL NEUROBIOL, V32, P59, DOI 10.1007/s10571-011-9734-x
· Hasegawa H, 2007, J NEUROSCI, V27, P14404, DOI 10.1523/JNEUROSCI.4908-07.2007
· Helmstaedter C, 2004, EPILEPSY BEHAV, V5, P696, DOI 10.1016/j.yebeh.2004.06.008
· Heuser K, 2011, SEIZURE-EUR J EPILEP, V20, P163, DOI 10.1016/j.seizure.2010.11.015
· Hinnebusch AG, 2014, ANN REV BIO IN PRESS
· Hoang SA, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0081972
· Holm PC, 2007, MOL CELL NEUROSCI, V34, P99, DOI 10.1016/j.mcn.2006.10.008
· Huang CT, 2008, NEUROPSYCHOBIOLOGY, V58, P171, DOI 10.1159/000191123
· Huang JH, 2011, FEBS J, V278, P1651, DOI 10.1111/j.1742-4658.2011.08085.x
· Huang YY, 2012, SYNAPSE, V66, P151, DOI 10.1002/syn.20995
· Huh YH, 2013, CELL MOL LIFE SCI, V70, P4841, DOI 10.1007/s00018-013-1447-5
· Jacquemet G, 2013, J CELL SCI, V126, P4121, DOI 10.1242/jcs.121988
· Janszky J, 2004, NEUROLOGY, V63, P1296
· Jung JJ, 2012, BIOSCIENCE REP, V32, P383, DOI 10.1042/BSR20120006
· Kanari Y, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059026
· Kienesberger PC, 2009, J LIPID RES, V50, pS63, DOI 10.1194/jlr.R800082-JLR200
· Kim H, 2009, PHARMACOGENOMICS, V10, P171, DOI 10.2217/14622416.10.2.171
· Kim JE, 2008, EXP NEUROL, V211, P128, DOI 10.1016/j.expneurol.2008.01.029
· Kim JE, 2010, J COMP NEUROL, V518, P4612, DOI 10.1002/cne.22482
· Kim KC, 2014, MOL NEUROBIOL, V49, P512, DOI 10.1007/s12035-013-8535-2
· Kim MH, 2009, J NEUROSCI, V29, P1586, DOI 10.1523/JNEUROSCI.4306-08.2009
· Kobayashi T, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035820
· Kobow K, 2012, EPILEPSIA, V53, P11, DOI 10.1111/epi.12031
· Kondo T, 2014, DEV CELL, V28, P94, DOI 10.1016/j.devcel.2013.11.021
· Krug A, 2014, EUR ARCH PSY CLIN N, V264, P103, DOI 10.1007/s00406-013-0428-x
· Kuraoka I, 2007, DNA REPAIR, V6, P841, DOI 10.1016/j.dnarep.2007.01.014
· Lauritzen F, 2013, BRAIN STRUC IN PRESS
· Lauritzen F, 2012, NEUROBIOL DIS, V45, P165, DOI 10.1016/j.nbd.2011.08.001
· Lauritzen F, 2011, NEUROBIOL DIS, V41, P577, DOI 10.1016/j.nbd.2010.11.005
· Leandro-Garcia LJ, 2010, CYTOSKELETON, V67, P214, DOI 10.1002/cm.20436
· Lee CH, 2012, MOL CELL NEUROSCI, V51, P61, DOI 10.1016/j.mcn.2012.07.010
· Lee MC, 2001, HUM PATHOL, V32, P643, DOI 10.1053/hupa.2001.24997
· Lee TS, 2006, ACTA NEUROPATHOL, V111, P351, DOI 10.1007/s00401-005-0017-9
· Lewerenz J, 2012, CELL DEATH DIFFER, V19, P847, DOI 10.1038/cdd.2011.165
· Lewerenz J, 2009, J BIOL CHEM, V284, P1106, DOI 10.1074/jbc.M807325200
· Lewerenz J, 2014, ANTIOXID REDOX SIGN, V20, P2907, DOI 10.1089/ars.2013.5455
· Linnartz B, 2013, GLIA, V61, P37, DOI 10.1002/glia.22359
· Linnartz-Gerlach B, 2014, NEUROSCIENCE, V275, P113, DOI 10.1016/j.neuroscience.2014.05.061
· Liu G, 2002, ONCOGENE, V21, P7195, DOI 10.1038/sj.onc.1205862
· Liu Y, 2008, J BIOL CHEM, V283, P6561, DOI 10.1074/jbc.M708096200
· Lu CF, 2010, NEUROSCI LETT, V484, P139, DOI 10.1016/j.neulet.2010.08.036
· Ludwig A, 2011, J NEUROSCI, V31, P644, DOI 10.1523/JNEUROSCI.2006-10.2011
· Lum H, 2002, AM J PHYSIOL-CELL PH, V282, pC59
· Ma YY, 2009, BMC GENOMICS, V10, DOI 10.1186/1471-2164-10-109
· Marat AL, 2011, J BIOL CHEM, V286, P13791, DOI 10.1074/jbc.R110.217067
· Margineanu DG, 2012, EPILEPSY RES, V98, P104, DOI 10.1016/j.eplepsyres.2011.10.006
· Matsuki H, 2013, GENES CELLS, V18, P135, DOI 10.1111/gtc.12023
· McClelland S, 2011, NEUROSCI LETT, V497, P155, DOI 10.1016/j.neulet.2011.02.032
· Medrihan L, 2013, NAT COMMUN, V4, DOI 10.1038/ncomms2515
· Menssen R, 2012, J BIOL CHEM, V287, P25602, DOI 10.1074/jbc.M112.363762
· Millard CJ, 2014, CANCER METAST REV, V33, P857, DOI 10.1007/s10555-014-9513-5
· Miller-Delaney SFC, 2012, J NEUROSCI, V32, P1577, DOI 10.1523/JNEUROSCI.5180-11.2012
· Miyagi M, 2011, NEUROSCIENCE, V176, P93, DOI 10.1016/j.neuroscience.2010.12.027
· Moorthamer M, 1999, BIOCHEM BIOPH RES CO, V255, P631, DOI 10.1006/bbrc.1999.0145
· Moreira-Filho CA, 2014, TRANSCRIPTOMICS HLTH, P79
· Mulley JC, 2013, EPILEPSIA, V54, pe122, DOI 10.1111/epi.12323
· Nam J, 2011, SEMIN CELL DEV BIOL, V22, P492, DOI 10.1016/j.semcdb.2011.06.005
· Narayanan T, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0067237
· Naylor DE, 2013, NEUROBIOL DIS, V54, P225, DOI 10.1016/j.nbd.2012.12.015
· Newman M., 2010, NETWORKS INTRO
· Newman M.E., 2004, PHYS REV E, V69, P26113, DOI 10.1103/PHYSREVE.69.026113
· Newman MEJ, 2003, SIAM REV, V45, P167, DOI 10.1137/S003614450342480
· N'Gouemo P, 2011, EXPERT OPIN THER TAR, V15, P1283, DOI 10.1517/14728222.2011.620607
· Ogawa M, 2013, BIOCHEM BIOPH RES CO, V440, P88, DOI 10.1016/j.bbrc.2013.09.022
· Otalora LFP, 2008, BRAIN RES, V1200, P116, DOI 10.1016/j.brainres.2008.01.017
· Pandithage R, 2008, J CELL BIOL, V180, P915, DOI 10.1083/jcb.200707126
· Patterson KP, 2014, NEUROTHERAPEUTICS, V11, P242, DOI 10.1007/s13311-014-0263-4
· Pechenino AS, 2009, NEUROBIOL LEARN MEM, V91, P313, DOI 10.1016/j.nlm.2008.09.017
· Perosa SR, 2002, BRAIN RES BULL, V58, P509, DOI 10.1016/S0361-9230(02)00822-5
· Poppe R, 1997, J NEUROCHEM, V69, P84
· Puskarjov M, 2014, EMBO REP, V15, P723, DOI 10.1002/embr.201438749
· Putkonen N, 2011, EUR J NEUROSCI, V34, P1212, DOI 10.1111/j.1460-9568.2011.07858.x
· Radzicki D, 2013, J NEUROSCI, V33, P9920, DOI 10.1523/JNEUROSCI.5482-12.2013
· Ramirez DMO, 2012, NEURON, V73, P121, DOI 10.1016/j.neuron.2011.10.034
· Ravenall SJ, 2002, EUR J NEUROSCI, V15, P281, DOI 10.1046/j.0953-816x.2001.01862.x
· Richardson RJ, 2013, CHEM-BIOL INTERACT, V203, P238, DOI 10.1016/j.cbi.2012.10.024
· Rosvall M, 2008, P NATL ACAD SCI USA, V105, P1118, DOI 10.1073/pnas.0706851105
· Rothermundt M, 2003, MICROSC RES TECHNIQ, V60, P614, DOI 10.1002/jemt.10303
· Rowley S, 2013, FREE RADICAL BIO MED, V62, P121, DOI 10.1016/j.freeradbiomed.2013.02.002
· Russo I, 2013, NEUROMOL MED, V15, P324, DOI 10.1007/s12017-013-8221-6
· Ryley PR, 2013, NEUROSCIENCE C, V248C, P602, DOI 10.1016/J.NEUR0SCIENCE.2013.06.029
· Saha S, 2013, J BIOL CHEM, V288, P7815, DOI 10.1074/jbc.M112.417196
· Sahni N, 2013, CURR OPIN GENET DEV, V23, P649, DOI 10.1016/j.gde.2013.11.002
· Saitoh F, 2004, J BIOL CHEM, V279, P29461, DOI 10.1074/jbc.M401471200
· Salat K, 2011, FUTURE MED CHEM, V3, P211, DOI [10.4155/fmc.10.298, 10.4155/FMC.10.298]
· Sanchez J, 2014, SEIZURE-EUR J EPILEP, V23, P448, DOI 10.1016/j.seizure.2014.03.003
· Santos SD, 2012, J BIOL CHEM, V287, P6868, DOI 10.1074/jbc.M111.322909
· Sasaki K, 2009, PEDIATR NEUROL, V41, P114, DOI 10.1016/j.pediatrneurol.2009.03.003
· Sasaki N, 2005, BIOCHEM BIOPH RES CO, V333, P131, DOI 10.1016/j.bbrc.2005.05.082
· Sato T, 2010, J COMP NEUROL, V518, P4513, DOI 10.1002/cne.22469
· Sequeira KM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0053204
· Sha L, 2014, MOL CELLULA IN PRESS
· Shen AG, 2002, NEUROSCI LETT, V327, P45, DOI 10.1016/S0304-3940(02)00381-6
· Shi Y, 2012, INT J INF TECH DECIS, V11, P1, DOI 10.1142/S0219622012010018
· Simms BA, 2014, NEURON, V82, P24, DOI 10.1016/j.neuron.2014.03.016
· Singh NA, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000649
· Smirnova E, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0065605
· Soerensen J, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001813
· Souchet B, 2014, NEUROBIOL DIS, V69, P65, DOI 10.1016/j.nbd.2014.04.016
· Steiger JL, 2004, J NEUROSCI, V24, P6115, DOI 10.1523/JNEUROSCI.1200-04.2004
· Steinhoff BJ, 1999, EPILEPSY RES, V36, P75, DOI 10.1016/S0920-1211(99)00026-1
· Teocchi MA, 2013, J NEUROINFLAMM, V10, DOI 10.1186/1742-2094-10-53
· Tian LJ, 2012, J BIOL CHEM, V287, P14718, DOI 10.1074/jbc.M111.335547
· Tiedje KE, 2010, NEUROCHEM INT, V57, P177, DOI 10.1016/j.neuint.2010.06.001
· Troller U, 2004, CELL SIGNAL, V16, P245, DOI 10.1016/S0898-6568(03)00135-9
· Turturici G, 2011, BIOCH RES INT, V2011, DOI [10.1155/2011/618127, DOI 10.1155/2011/618127]
· van den Heuvel MP, 2011, J NEUROSCI, V31, P15775, DOI 10.1523/JNEUROSCI.3539-11.2011
· Van Kuilenburg ABP, 1999, HUM GENET, V104, P1, DOI 10.1007/PL00008711
· Vezzani A, 2014, EPILEPSY CURR, V14, P3, DOI 10.5698/1535-7511-14.s2.3
· Vielhaber S, 2008, EPILEPSIA, V49, P40, DOI 10.1111/j.1528-1167.2007.01280.x
· Viggiano A, 2012, BRAIN RES, V1471, P66, DOI 10.1016/j.brainres.2012.06.048
· Villarroel-Campos D, 2014, J NEUROCHEM, V129, P240, DOI 10.1111/jnc.12676
· Wagnon JL, 2012, PLOS GENET, V8, DOI 10.1371/journal.pgen.1003067
· Wang Y, 2006, MOL MEMBR BIOL, V23, P377, DOI 10.1080/09687860600776734
· Wang YJ, 2012, J CELL BIOCHEM, V113, P2696, DOI 10.1002/jcb.24145
· Wei ZY, 2011, MOL CELL, V43, P586, DOI 10.1016/j.molcel.2011.07.021
· Wende H, 1999, MAMM GENOME, V10, P154, DOI 10.1007/s003359900961
· Weser S, 2004, J BIOL CHEM, V279, P27022, DOI 10.1074/jbc.M312790200
· West S, 2008, NUCLEIC ACIDS RES, V36, P905, DOI 10.1093/nar/gkm1112
· White HS, 2014, NEUROTHERAPEUTICS, V11, P373, DOI 10.1007/s13311-013-0250-1
· Willemsen MH, 2011, J MED GENET, V48, P810, DOI 10.1136/jmedgenet-2011-100294
· Witte H, 2008, J CELL BIOL, V180, P619, DOI [10.1083/jcb.200707042, 10.1083/icb.200707042]
· Woods JO, 2013, BMC BIOINFORMATICS, V14, DOI 10.1186/1471-2105-14-203
· Wu CC, 2011, MOL CELL BIOL, V31, P2715, DOI 10.1128/MCB.05151-11
· Xiao F, 2008, BRAIN RES, V1233, P168, DOI 10.1016/j.brainres.2008.07.101
· Yang F, 2008, HIPPOCAMPUS, V18, P460, DOI 10.1002/hipo.20409
· Yang JW, 2006, AMINO ACIDS, V30, P477, DOI 10.1007/s00726-005-0281-y
· Yang RQ, 2011, MOL CELL BIOL, V31, P542, DOI 10.1128/MCB.01162-10
· Yoo DY, 2015, NEUROL RES, V37, P69, DOI 10.1179/1743132814Y
· You JJ, 2010, J BIOL CHEM, V285, P11652, DOI 10.1074/jbc.M109.051094
· Zha QQ, 2008, J NEUROCHEM, V105, P68, DOI 10.1111/j.1471-4159.2007.05110.x
· Zhang BL, 2007, BIOCHEM BIOPH RES CO, V356, P536, DOI 10.1016/j.bbrc.2007.02.160
· Zhang C, 1999, J NEUROCHEM, V73, P1650, DOI 10.1046/j.1471-4159.1999.0731650.x
· Zhang DM, 1998, J NEUROSCI, V18, P3314
· Zhang SJ, 2009, PLOS GENET, V5, DOI 10.1371/journal.pgen.1000604
· Zhou Yun, 2013, Front Endocrinol (Lausanne), V4, P165, DOI 10.3389/fendo.2013.00165
· Zhu XW, 2007, GENE DEV, V21, P1010, DOI 10.1101/gad.1528707
dc.description.index MEDLINE
hcfmusp.citation.scopus 5
hcfmusp.citation.wos 4
hcfmusp.affiliation.country Brasil


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search DSpace



Browse

My Account

Statistics