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https://observatorio.fm.usp.br/handle/OPI/11819| Title: | Glutathione-mediated effects of lithium in decreasing protein oxidation induced by mitochondrial complex I dysfunction |
| Authors: | NASCIMENTO, Camila; KIM, Helena Kyunghee; YOUNG, L. Trevor; MENDONCA, Karina Martinez; GRINBERG, Lea Tenenholz; LAFER, Beny; ANDREAZZA, Ana Cristina |
| Citation: | JOURNAL OF NEURAL TRANSMISSION, v.122, n.6, p.741-746, 2015 |
| Abstract: | The aim of this study was to elucidate whether glutathione is involved in lithium's ability to decrease carbonylation and nitration produced by complex I inhibition, which is consistently found in BD. Neuroblastoma cells were treated with rotenone, a complex I inhibitor. Our results suggest that glutathione is essential for lithium's ability to ameliorate rotenone-induced protein carbonylation, but not nitration. |
| Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPS Artigos e Materiais de Revistas Científicas - FM/MPT Artigos e Materiais de Revistas Científicas - LIM/21 Artigos e Materiais de Revistas Científicas - LIM/22 Artigos e Materiais de Revistas Científicas - ODS/03 |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| art_NASCIMENTO_Glutathionemediated_effects_of_lithium_in_decreasing_protein_oxidation_2015.PDF Restricted Access | 2.15 MB | Adobe PDF | View/Open Request a copy |
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