Malaria in Pregnancy Interacts with and Alters the Angiogenic Profiles of the Placenta

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author ATAIDE, Ricardo
MURILLO, Oscar
DOMBROWSKI, Jamille G.
SOUZA, Rodrigo M.
LIMA, Flavia A.
LIMA, Giselle F. M. C. FMUSP-HC
HRISTOV, Angelica D. FMUSP-HC
VALLE, Suiane C. N.
SANTI, Silvia M. Di FMUSP-HC
EPIPHANIO, Sabrina FMUSP-HC
MARINHO, Claudio R. F.
dc.date.issued 2015
dc.identifier.citation PLOS NEGLECTED TROPICAL DISEASES, v.9, n.6, article ID e0003824, 15p, 2015
dc.identifier.issn 1935-2735
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/11850
dc.description.abstract Malaria in pregnancy remains a substantial public health problem in malaria-endemic areas with detrimental outcomes for both the mother and the foetus. The placental changes that lead to some of these detrimental outcomes have been studied, but the mechanisms that lead to these changes are still not fully elucidated. There is some indication that imbalances in cytokine cascades, complement activation and angiogenic dysregulation might be involved in the placental changes observed. Nevertheless, the majority of studies on malaria in pregnancy (MiP) have come from areas where malaria transmission is high and usually restricted to Plasmodium falciparum, the most pathogenic of the malaria parasite species. We conducted a cross-sectional study in Cruzeiro do Sul, Acre state, Brazil, an area of low transmission and where both P. vivax and P. falciparum circulate. We collected peripheral and placental blood and placental biopsies, at delivery from 137 primigravid women and measured levels of the angiogenic factors angiopoietin (Ang)-1, Ang-2, their receptor Tie-2, and several cytokines and chemokines. We measured 4 placental parameters (placental weight, syncytial knots, placental barrier thickness and mononuclear cells) and associated these with the levels of angiogenic factors and cytokines. In this study, MiP was not associated with severe outcomes. An increased ratio of peripheral Tie-2: Ang-1 was associated with the occurrence of MiP. Both Ang-1 and Ang-2 had similar magnitudes but inverse associations with placental barrier thickness. Malaria in pregnancy is an effect modifier of the association between Ang-1 and placental barrier thickness.
dc.description.sponsorship · Conselho Nacional de Desenvolvimento Cientifico e Tecnologico CNPq [404213/2012, 475103/2013-0]
· Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior CAPES [AUX-PE-PNPD 2751/2010]
· Fundacao de Apoio a Pesquisa do Estado de Sao Paulo FAPESP [2009/53889-0, 2009/53256-7]
· FAPESP [2011/20921-8, 2012/04755-3]
· Universidade Federal do Acre [141946/2012-1]
dc.language.iso eng
dc.publisher PUBLIC LIBRARY SCIENCE
dc.relation.ispartof Plos Neglected Tropical Diseases
dc.rights openAccess
dc.subject.other plasmodium-falciparum malaria; low-birth-weight; complement activation; brazilian amazon; vivax infection; ifn-gamma; alpha; women; area; angiopoietins
dc.title Malaria in Pregnancy Interacts with and Alters the Angiogenic Profiles of the Placenta
dc.type article
dc.rights.holder Copyright PUBLIC LIBRARY SCIENCE
dc.description.group LIM/49
dc.identifier.doi 10.1371/journal.pntd.0003824
dc.identifier.pmid 26090803
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author LIMA, Giselle F. M. C.:FM:
hcfmusp.author HRISTOV, Angelica D.:FM:
hcfmusp.author SANTI, Silvia M. Di:FM:
hcfmusp.author EPIPHANIO, Sabrina:IMT:
hcfmusp.author.external · ATAIDE, Ricardo:Univ Sao Paulo ICB USP, Dept Parasitol, Sao Paulo, SP, Brazil; Burnet Inst, Ctr Biomed Res, Melbourne, Australia
· MURILLO, Oscar:Univ Sao Paulo ICB USP, Dept Parasitol, Sao Paulo, SP, Brazil
· DOMBROWSKI, Jamille G.:Univ Sao Paulo ICB USP, Dept Parasitol, Sao Paulo, SP, Brazil
· SOUZA, Rodrigo M.:Univ Sao Paulo ICB USP, Dept Parasitol, Sao Paulo, SP, Brazil; Univ Fed Acre, Ctr Multidisciplinar, Cruzeiro Do Sul, Acre, Brazil
· LIMA, Flavia A.:Univ Sao Paulo ICB USP, Dept Parasitol, Sao Paulo, SP, Brazil
· VALLE, Suiane C. N.:Univ Fed Acre, Ctr Multidisciplinar, Cruzeiro Do Sul, Acre, Brazil
· MARINHO, Claudio R. F.:Univ Sao Paulo ICB USP, Dept Parasitol, Sao Paulo, SP, Brazil
hcfmusp.origem.id WOS:000357398100029
hcfmusp.origem.id 2-s2.0-84934776958
hcfmusp.publisher.city SAN FRANCISCO
hcfmusp.publisher.country USA
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dc.description.index MEDLINE
hcfmusp.citation.scopus 12
hcfmusp.citation.wos 11
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Austrália


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