Investigation of Central Nervous System Dysfunction in Chronic Pelvic Pain Using Magnetic Resonance Spectroscopy and Noninvasive Brain Stimulation

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art_SIMIS_Investigation_of_Central_Nervous_System_Dysfunction_in_Chronic_2015.PDF (245.78 KB)
Citações na Scopus
43
Tipo de produção
article
Data de publicação
2015
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY-BLACKWELL
Autores
REIDLER, Jay S.
MACEA, Debora Duarte
DUARTE, Ingrid Moreno
WANG, Xiaoen
LENKINSKI, Robert
PETROZZA, John C.
FREGNI, Felipe
Citação
PAIN PRACTICE, v.15, n.5, p.423-432, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
BackgroundRecent studies demonstrate that chronic pelvic pain is associated with altered afferent sensory input resulting in maladaptive changes in the neural circuitry of pain. To better understand the central changes associated with chronic pelvic pain, we investigated the contributions of critical pain-related neural circuits using single-voxel proton magnetic resonance spectroscopy (MRS) and transcranial direct current stimulation (tDCS). MethodsWe measured concentrations of neural metabolites in 4 regions of interest (thalamus, anterior cingulate cortex, primary motor, and occipital cortex [control]) at baseline and after 10days of active or sham tDCS in patients with chronic pelvic pain. We then compared our results to those observed in healthy controls, matched by age and gender. ResultsWe observed a significant increase in pain thresholds after active tDCS compared with sham conditions. There was a correlation between metabolite concentrations at baseline and quantitative sensory assessments. Chronic pelvic pain patients had significantly lower levels of NAA/Cr in the primary motor cortex compared with healthy patients. ConclusionstDCS increases pain thresholds in patients with chronic pelvic pain. Biochemical changes in pain-related neural circuits are associated with pain levels as measured by objective pain testing. These findings support the further investigation of targeted cortical neuromodulatory interventions for chronic pelvic pain.
Palavras-chave
chronic pelvic pain, brain stimulation, transcranial direct current stimulation, tDCS, magnetic resonance spectroscopy
URI
https://observatorio.fm.usp.br/handle/OPI/11951
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Coleções
Artigos e Materiais de Revistas Científicas - HC/Outros