Do Tobacco and Alcohol Modify Protective Effects of Diet on Oral Carcinogenesis?

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art_CARVALHO_Do_Tobacco_and_Alcohol_Modify_Protective_Effects_of_2012.PDF (128 KB)
Citações na Scopus
13
Tipo de produção
article
Data de publicação
2012
Editora
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI
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Scopus
Web of Science
PubMed
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Título do Volume
Autores
TOPORCOV, Tatiana Natasha
TAVARES, Giovanna Emann
ROTUNDO, Ligia Drovandi Braga
VACCAREZZA, Gabriela Fuerst
BIAZEVIC, Maria Gabriela Haye
BRASILEIRO, Rosana Sarmento
KOWALSKI, Luiz Paulo
ANTUNES, Jose Leopoldo Ferreira
Autor de Grupo de pesquisa
Editores
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Organizadores
Citação
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, v.64, n.8, p.1182-1189, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Recent systematic reviews concluded that the frequent consumption of fruits and vegetables is inversely associated with the risk of oral cancer. We assessed this association, specifically comparing results obtained to nonsmokers and smokers, as well to nondrinkers and drinkers. We conducted a case-control study involving 296 patients with oral squamous cell carcinoma (cases) attended in 3 major hospitals of Sao Paulo, Brazil, paired with 296 controls, recruited from outpatient units of the same hospitals. Multivariate models assessed the effect of fruits and salads according to smoking and drinking. The intake of fruit was associated with the prevention of the disease in the specific assessment among light [odds ratio (OR) = 0.46; 95% confidence interval (CI) = 0.27-0.78) and heavy (OR = 0.30; 95% CI = 0.14-0.65) smokers. The same was observed for vegetables consumption. For nonsmokers, no fruit (OR = 50; 95% CI = 0.22-1.12) or vegetable (for tomato, OR = 0.53; 95% CI = 0.31-0.93) was associated with reduced risk of oral and oropharyngeal cancer. Similar results were found in the stratified analysis according to drinking status with OR = 0.51 (95% CI = 0.30-0.87) and 0.18 for fruits (95% CI = 0.07-0.45), respectively, for light and heavy drinkers. This observation suggests that the protective effect of fruit and salad intake may modulate the deleterious effects from tobacco and alcohol.
Palavras-chave
URI
https://observatorio.fm.usp.br/handle/OPI/1224
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/28