Periodontitis Response to Anti-TNF Therapy in Ankylosing Spondylitis

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art_FABRI_Periodontitis_Response_to_AntiTNF_Therapy_in_Ankylosing_Spondylitis_2015.PDF (142.68 KB)
Citações na Scopus
22
Tipo de produção
article
Data de publicação
2015
Editora
LIPPINCOTT WILLIAMS & WILKINS
DOI
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Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
FABRI, Gisele Maria C.
SAVIOLI, Cynthia
SIQUEIRA, Jose Tadeu T.
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v.21, n.7, p.341-345, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background Recently, it has been demonstrated that patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA) have a higher risk of periodontitis; however, the effect of anti-TNF therapy in periodontal status of patients with AS and particularly in dental attachment is not known. Objective To evaluate longitudinally the local periodontal effect of TNF-antagonist in AS and compare to patients with RA. Methods Fifteen patients with AS and 15 RA control patients were prospectively evaluated at baseline and after 6 months (6 M) of anti-TNF therapy. Periodontal assessment included: probing pocket depth (PPD), clinical attachment level (CAL), gingival bleeding index, and plaque index. Rheumatologic clinical and laboratory evaluations were the following: Bath AS Disease Activity Index, Bath AS Metrology Index, Bath AS Functional Index, C-reactive protein and erythrocyte sedimentation rate for AS and Disease Activity Score 28 joints, and C-reactive protein and erythrocyte sedimentation rate for patients with RA. Results At baseline, periodontal parameters were alike in AS and RA (P > 0.05). After 6 M of anti-TNF therapy, clinical and laboratory parameters of rheumatic diseases decreased significantly in the patients with AS and RA (P < 0.05). A significant improvement in periodontal attachment measurements were observed in the patients with AS (PPD, 2.18 vs 1.94 mm; P = 0.02; CAL, 2.29 vs.2.02 mm; P = 0.03), but not in RA (PPD, 1.92 vs 2.06 mm; P = 0.06; CAL, 2.14 vs 2.28 mm; P = 0.27). Oral hygiene and gingival inflammation remained unchanged from baseline to 6-M evaluation in AS and RA (P > 0.05). Conclusion Patients with AS under anti-TNF improved periodontal attachment. The mechanism for this effect needs further studies.
Palavras-chave
ankylosing spondylitis, periodontal disease, rheumatoid arthritis, periodontium, TNF-alpha, rheumatic diseases
URI
https://observatorio.fm.usp.br/handle/OPI/12303
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/17