Body mass index and cognitive function: the potential for reverse causation

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art_SUEMOTO_Body_mass_index_and_cognitive_function_the_potential_2015.PDF (569.1 KB)
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89
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article
Data de publicação
2015
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NATURE PUBLISHING GROUP
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Scopus
Web of Science
PubMed
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GILSANZ, P.
MAYEDA, E. R.
GLYMOUR, M. M.
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Citação
INTERNATIONAL JOURNAL OF OBESITY, v.39, n.9, p.1383-1389, 2015
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Resumo
OBJECTIVE: Higher late life body mass index (BMI) is unrelated to or even predicts lower risk of dementia in late life, a phenomenon that may be explained by reverse causation due to weight loss during preclinical phases of dementia. We aim to investigate the association of baseline BMI and changes in BMI with dementia in a large prospective cohort, and to examine whether weight loss predicts cognitive function. METHODS: Using a national cohort of adults average age 58 years at baseline in 1994 (n = 7029), we investigated the associations between baseline BMI in 1994 and memory scores from 2000 to 2010. We also examined the association of BMI change from 1994 to 1998 with memory scores from 2000 to 2010. Last, to investigate reverse causation, we examined whether memory scores in 1996 predicted BMI trajectories from 2000 to 2010. RESULTS: Baseline overweight predicted better memory scores 6 to 16 years later (beta = 0.012, 95% confidence interval (CI) = 0.001; 0.023). Decline in BMI predicted lower memory scores over the subsequent 12 years (beta = -0.026, 95% CI = -0.041; -0.011). Lower memory scores at mean age 60 years in 1996 predicted faster annual rate of BMI decline during follow-up (beta = -0.158 kgm(-2) per year, 95% CI = -0.223; -0.094). CONCLUSION: Consistent with reverse causation, greater decline in BMI over the first 4 years of the study was associated with lower memory scores over the next decade and lower memory scores was associated with a decline in BMI. These findings suggest that preclinical dementia predicts weight loss for people as early as their late 50s.
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https://observatorio.fm.usp.br/handle/OPI/12315
Referências
  1. JORM AF, 1989, PSYCHOL MED, V19, P1015
  2. Fitzpatrick AL, 2009, ARCH NEUROL-CHICAGO, V66, P336, DOI 10.1001/archneurol.2008.582
  3. Dahl AK, 2008, J AM GERIATR SOC, V56, P2261, DOI 10.1111/j.1532-5415.2008.01958.x
  4. Stewart R, 2005, ARCH NEUROL-CHICAGO, V62, P55, DOI 10.1001/archneur.62.1.55
  5. Luchsinger JA, 2009, CURR OPIN CLIN NUTR, V12, P15, DOI 10.1097/MCO.0b013e32831c8c71
  6. Loef M, 2013, OBESITY, V21, pE51, DOI 10.1002/oby.20037
  7. Nourhashemi F, 2003, NEUROLOGY, V60, P117
  8. Xu WL, 2011, NEUROLOGY, V76, P1568, DOI 10.1212/WNL.0b013e3182190d09
  9. Anstey KJ, 2011, OBES REV, V12, pe426, DOI 10.1111/j.1467-789X.2010.00825.x
  10. Rosengren A, 2005, ARCH INTERN MED, V165, P321, DOI 10.1001/archinte.165.3.321
  11. Morris JC, 2005, ALZ DIS ASSOC DIS, V19, P163
  12. Knopman DS, 2007, NEUROLOGY, V69, P739, DOI 10.1212/01.wnl.0000267661.65586.33
  13. Ready RE, 2003, AM J GERIAT PSYCHIAT, V11, P222, DOI 10.1176/appi.ajgp.11.2.222
  14. Dahl A, 2010, J GERONTOL A-BIOL, V65, P57, DOI 10.1093/gerona/glp035
  15. Hernan MA, 2000, EPIDEMIOLOGY, V11, P561, DOI 10.1097/00001648-200009000-00012
  16. Dahl AK, 2013, INT J OBESITY, V37, P296, DOI 10.1038/ijo.2012.37
  17. Hughes TF, 2009, NEUROLOGY, V72, P1741, DOI 10.1212/WNL.0b013e3181a60a58
  18. Sperling RA, 2011, ALZHEIMERS DEMENT, V7, P280, DOI 10.1016/j.jalz.2011.03.003
  19. Prince M, 2013, ALZHEIMERS DEMENT, V9, P63, DOI 10.1016/j.jalz.2012.11.007
  20. Juster FT, 1995, J HUM RESOUR, V30, pS7, DOI 10.2307/146277
  21. Johnson DK, 2006, ARCH NEUROL-CHICAGO, V63, P1312, DOI 10.1001/archneur.63.9.1312
  22. Whitmer RA, 2007, CURR ALZHEIMER RES, V4, P103, DOI 10.2174/156720507780362047
  23. Weuve J, 2012, EPIDEMIOLOGY, V23, P119, DOI 10.1097/EDE.0b013e318230e861
  24. Oreopoulos A, 2009, CLIN GERIATR MED, V25, P643, DOI 10.1016/j.cger.2009.07.005
  25. Buchman AS, 2005, NEUROLOGY, V65, P892, DOI 10.1212/01.wnl.0000176061.33817.90
  26. Driscoll I, 2011, OBESITY, V19, P1595, DOI 10.1038/oby.2011.23
  27. BarrettConnor E, 1996, J AM GERIATR SOC, V44, P1147
  28. BRAAK H, 1991, ACTA NEUROPATHOL, V82, P239
  29. Brandt J., 1988, NEUROPSY NEUROPSY BE, V1, P111, DOI 10.1159/000264678
  30. Center for Disease Control and Prevention (CDC), US LIF TABL
  31. Charakida M, 2014, LANCET DIABETES ENDO, V2, P648, DOI 10.1016/S2213-8587(14)70103-2
  32. Droyvold WB, 2005, INT J OBESITY, V29, P650, DOI 10.1038/sj.ijo.0802944
  33. Dupre ME, 2009, BRIT MED J, V338, DOI 10.1136/bmj.b1175
  34. Hassing LB, 2009, INT J OBESITY, V33, P893, DOI 10.1038/ijo.2009.104
  35. Kovacs T, 2001, NEUROREPORT, V12, P285
  36. Langa KM, 2005, NEUROEPIDEMIOLOGY, V25, P181, DOI 10.1159/000087448
  37. Lawlor DA, 2010, BRIT MED J, V341, DOI 10.1136/bmj.c6224
  38. BLAND JM, 1986, LANCET, V1, P307
  39. Power BD, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0017902
  40. Power BD, 2013, INT PSYCHOGERIATR, V25, P467, DOI 10.1017/S1041610212001834
  41. RADLOFF L S, 1977, Applied Psychological Measurement, V1, P385, DOI 10.1177/014662167700100306
  42. Sperling R, 2014, NEURON, V84, P608, DOI 10.1016/j.neuron.2014.10.038
  43. Turvey C L, 1999, Int Psychogeriatr, V11, P139, DOI 10.1017/S1041610299005694
  44. Whitmer RA, 2005, BRIT MED J, V330, P1360, DOI 10.1136/bmj.38446.466238.E0
  45. WHO, 1999, WHO TECHN REP SER
  46. Wu Q, 2013, ALZ DIS ASSOC DIS, V27, P207, DOI 10.1097/WAD.0b013e31826cfe90
  47. Yang EJ, 2014, J AM GERIATR SOC, V62, P40, DOI 10.1111/jgs.12606

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - LIM/22