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Complexity of malaria transmission dynamics in the Brazilian Atlantic Forest
CURRENT RESEARCH IN PARASITOLOGY & VECTOR-BORNE DISEASES, v.1, article ID 100032, 8p, 2021
Plasmodium malariae and Plasmodium vivax are protozoan parasites that can cause malaria in humans. They are genetically indistinguishable from, respectively, Plasmodium brasilianum and Plasmodium simium, i.e. parasites infecting New World non-human primates in South America. In the tropical rainf...
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New Allele-Specific Oligonucleotide (ASO) amplifications for Toxoplasma gondii rop18 allele typing: Analysis of 86 human congenital infections in Brazil
ACTA TROPICA, v.247, article ID 107011, 8p, 2023
This study aimed to detect and differentiate Toxoplasma gondii by the allele typing of its polymorphic rop18 gene. For this purpose, a novel genotyping system using allele-specific oligonucleotides (ASOs) was designed, consisting of three ASO pairs. The first and third pairs specifically amplify ...
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Arbovirus Surveillance in a Private Brazilian Hospital: A Four-Year Retrospective Study
JOURNAL OF MOLECULAR DIAGNOSTICS, v.21, n.6, p.1160-1160, 2019
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Hemocromatose hereditária
Evangelista, Andreia Silva; Nakhle, Maria Cristina; Cançado, Eduardo Luiz Rachid. Hemocromatose hereditária. In: Pinho, João Renato Rebello; Ribeiro Junior, Ulysses (eds). Genômica e marcadores moleculares em gastroenterologia e hepatologia. SÃO PAULO: Sarvier, 2017. p.364-373.
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Technical comparison of MinIon and Illumina technologies for genotyping Chikungunya virus in clinical samples
JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY, v.21, n.1, article ID 88, 8p, 2023
New-generation sequencing (NGS) techniques have brought the opportunity for genomic monitoring of several microorganisms potentially relevant to public health. The establishment of different methods with different mechanisms provides a wide choice, taking into account several aspects. With that i...
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Deep serological profiling of the <i>Trypanosoma cruzi</i> TSSA antigen reveals different epitopes and modes of recognition by Chagas disease patients
PLOS NEGLECTED TROPICAL DISEASES, v.17, n.8, article ID e0011542, 22p, 2023
BackgroundTrypanosoma cruzi, the agent of Chagas disease, displays a highly structured population, with multiple strains that can be grouped into 6-7 evolutionary lineages showing variable eco-epidemiological traits and likely also distinct disease-associated features. Previous works have shown t...
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Population-based genomic study of<i> Plasmodium</i><i> vivax</i> malaria in seven Brazilian states and across South America
LANCET REGIONAL HEALTH-AMERICAS, v.18, article ID 100420, 21p, 2023
Background Brazil is a unique and understudied setting for malaria, with complex foci of transmission associated with human and environmental conditions. An understanding of the population genomic diversity of P. vivax parasites across Brazil can support malaria control strategies.Methods Through...
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Characterization of Torquetenovirus in amniotic fluid at the time of <i>in utero</i> fetal surgery: correlation with early premature delivery and respiratory distress
FRONTIERS IN MEDICINE, v.10, article ID 1161091, 8p, 2023
Torquetenovirus (TTV) is a commensal virus present in many healthy individuals. Although considered to be non-pathogenic, its presence and titer have been shown to be indicative of altered immune status in individuals with chronic infections or following allogeneic transplantations. We evaluated ...
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Association between development of severe COVID-19 and a polymorphism in the <i>CIAS1</i> gene that codes for an inflammasome component
SCIENTIFIC REPORTS, v.13, n.1, article ID 11252, 5p, 2023
An elevated pro-inflammatory cytokine response is associated with severe life-threatening symptoms in individuals with Coronavirus Disease-2019 (COVID). The inflammasome is an intracellular structure responsible for generation of interleukin (IL)-1 & beta; and IL-18. NALP3, a product of the CIAS1...
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Detailed characterization of Redondovirus in saliva of SARS-CoV-2-infected individuals in Sao Paulo, Brazil
PLOS ONE, v.18, n.8, article ID e0291027, 10p, 2023
BackgroundRedondovirus (ReDoV) is a DNA virus present in the respiratory tract of many healthy individuals. Since SARS-CoV-2, the virus responsible for COVID-19, also primarily infects the same site, we evaluated whether ReDoV was present at increased frequency in patients with COVID-19 and influ...
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