Health-related quality of life evaluated by Pediatric Quality of Life Inventory 4.0 in pediatric leprosy patients with musculoskeletal manifestations

Objective: To evaluate the health-related quality of life (HRQL) in pediatric leprosy patients. Methods: A cross-sectional study included 47 leprosy patients and 45 healthy subjects. The HRQL was measured by Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0), and evaluated physical, emotional, social and school domains. The leprosy patients were classified by Ridley and Jopling classification criteria and assessed according to clinical musculoskeletal manifestations, laboratory and radiographic examinations. Results: The median of current age was similar in leprosy patients and controls [12(6-18) vs. 15(5-18) years, p = 0.384], likewise the frequencies of female gender (p = 0.835) and middle/lower Brazilian socio-economic classes (p = 1.0). The domain school activities according the child-self report was significantly lower in leprosy patients compared to controls in the age group of 13-18 years [75(45-100) vs. 90(45-100), p = 0.021]. The other domains were alike in both groups (p > 0.05). At least one musculoskeletal manifestation (arthralgia, arthritis and/or myalgia) was observed in 15% of leprosy patients and none in controls (p = 0.012). Further comparison between all leprosy patients showed that the median of the physical capacity domain [81.25(50-100) vs. 98.44(50-100), p = 0.036] and school activities domain by child-self report [60(50-85) vs. 80(45-100), p = 0.042] were significantly lower in patients with musculoskeletal manifestations compared to patients without these manifestations. No differences were evidenced between the other HRQL parameters in both groups, reported by patients and parents (p > 0.05). Conclusions: Reduced physical capacity and school activities domains were observed in pediatric leprosy patients with musculoskeletal manifestations.
Objetivo: Avaliar a qualidade de vida relacionada à saúde (QVRS) em pacientes pediátricos com hanseníase. Métodos: Estudo transversal com 47 pacientes com hanseníase e 45 indivíduos saudáveis. A QVRS foi mensurada pelo Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0) e os domí- nios físico, emocional, social e escolar foram avaliados. Os pacientes com hanseníase foram classificados pelos critérios de Ridley e Jopling e avaliados de acordo com manifestac¸ões clínicas musculoesqueléticas, laboratoriais e exames radiográficos. Resultados: A média de idade atual foi similar em pacientes com hanseníase e controles [12(6-18) vs. 15(5-18) anos, p = 0,384], assim como frequências do sexo feminino (p = 0,835) e classes socioeconômicas brasileiras média/baixa (p = 1,0). De acordo com a autoavaliac¸ão da crianc¸a relacionada com as atividades escolares, esse domínio foi significativamente menor nos pacientes com hanseníase em relac¸ão aos controles de 13-18 anos [75(45-100) vs. 90(45-100), p = 0,021]. Os outros domínios foram semelhantes em ambos os grupos (p > 0,05). Pelo menos uma manifestac¸ão musculoesquelética (artralgia, artrite e/ou mialgia) foi observada em 15% dos pacientes com hanseníase e nenhuma nos controles (p = 0,012). Uma comparac¸ão mais detalhada entre pacientes com hanseníase mostrou que a mediana do domínio de capacidade física [81,25(50-100) vs. 98,44(50-100), p = 0,036] e de atividades escolares pela autoavaliac¸ão da crianc¸a [60(50-85) vs. 80(45-100), p = 0,042] era significantemente menor nos pacientes com manifestac¸ões musculoesqueléticas em comparac¸ão com a dos pacientes sem essas manifestac¸ões. (1) Nenhuma diferenc¸a foi evidenciada entre os outros parâmetros de QVRS em ambos os grupos relatados pelos pacientes e pais (p > 0,05).

Palavras-chave

Leprosy, Children, Hansen's disease, Health-related quality of life, Arthritis, Lepra, Criança, Hanseníase, Qualidade de vida relacionada à saúde, Artrite

URI

https://observatorio.fm.usp.br/handle/OPI/12431

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Coleções

Artigos e Materiais de Revistas Científicas - FM/MPE
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - LIM/36
Artigos e Materiais de Revistas Científicas - ODS/03

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