Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/12573
Title: | Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival |
Authors: | MARTINS, Sandra F.; AMORIM, Ricardo; MOTA, Silvia Coelho; COSTA, Luis; PARDAL, Fernando; RODRIGUES, Mesquita; LONGATTO-FILHO, Adhemar |
Citation: | BIOMED RESEARCH INTERNATIONAL, article ID 131685, 13p, 2015 |
Abstract: | Colorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumour-associated molecules according to individual tumour biology; however, so far, no ideal molecular marker has been found to predict disease progression. We tested Ki-67 proliferation marker in primary and lymph node metastasis of CRC. We observed a statistical significant difference between the positive rates of neoplastic cells positively stained by Ki-67 in both sites, with remarkable increased number of Ki-67 positive cells in primary tumor cells compared to cancer cells that invaded lymph nodes. We can speculate that the metastatic CRC in lymph node can be more resistant to the drugs that target cellular division. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - LIM/14 Artigos e Materiais de Revistas Científicas - ODS/03 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_MARTINS_Ki67_Expression_in_CRC_Lymph_Node_Metastasis_Does_2015.PDF | publishedVersion (English) | 4.18 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.