Effectiveness of influenza vaccination of schoolchildren in the city of Sao Paulo, Brazil, 2009

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author GATTAS, Vera L.
CARDOSO, Maria Regina A.
MONDINI, Gabriela
MACHADO, Clarisse M. FMUSP-HC
LUNA, Expedito J. A. FMUSP-HC
dc.date.issued 2015
dc.identifier.citation INFLUENZA AND OTHER RESPIRATORY VIRUSES, v.9, n.6, p.323-330, 2015
dc.identifier.issn 1750-2640
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/12589
dc.description.abstract Background Children play an important role in maintaining the transmission of influenza. Evidence suggests that vaccination of school-age children can reduce transmission to unvaccinated household contacts. We evaluated the direct and indirect effectiveness of the 2009 inactivated seasonal influenza vaccine in vaccinated schoolchildren and their unvaccinated household contacts. Methods This was a double-blind cluster randomized trial involving 10 schools and 1742 schoolchildren as well as 5406 household contacts. The schools were randomly assigned to receive the influenza vaccine or the control vaccine. After vaccination, the schoolchildren and household contacts were followed for 6 months to identify cases of acute respiratory infection (ARI). Reverse-transcriptase polymerase chain reaction was performed for the diagnosis of influenza. Results A total of 632 ARI cases were detected. Of those, 103 tested positive for influenza virus (influenza virus A[H1N1] pdm09 virus in 55 and seasonal influenza viruses in 48). The effectiveness of the vaccine in protecting against seasonal influenza virus infection was 65>0% for the household contacts (95% CI, 19.6-84.3) and 65.0% for the schoolchildren (95% CI, 20.9-84.5). Conclusion Vaccination of schoolchildren significantly protected them and their household contacts against seasonal influenza.
dc.description.sponsorship · Butantan Foundation
dc.language.iso eng
dc.publisher WILEY-BLACKWELL
dc.relation.ispartof Influenza and Other Respiratory Viruses
dc.rights openAccess
dc.subject Effectiveness; influenza; intervention study; school-age children; vaccination
dc.subject.other acute respiratory-infections; community-acquired pneumonia; real-time pcr; multiplex pcr; viral-infections; human bocavirus; pathogens; children; viruses; assay
dc.title Effectiveness of influenza vaccination of schoolchildren in the city of Sao Paulo, Brazil, 2009
dc.type article
dc.rights.holder Copyright WILEY-BLACKWELL
dc.description.group LIM/52
dc.identifier.doi 10.1111/irv.12328
dc.identifier.pmid 26018131
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author MACHADO, Clarisse M.:HC:INCOR
hcfmusp.author LUNA, Expedito J. A.:IMT:IMT
hcfmusp.author.external · GATTAS, Vera L.:Inst Butantan, BR-05503900 Sao Paulo, SP, Brazil
· CARDOSO, Maria Regina A.:Univ Sao Paulo, Sch Publ Hlth, Sao Paulo, Brazil
· MONDINI, Gabriela:Inst Butantan, BR-05503900 Sao Paulo, SP, Brazil
hcfmusp.origem.id WOS:000362915800008
hcfmusp.origem.id 2-s2.0-84944057668
hcfmusp.publisher.city HOBOKEN
hcfmusp.publisher.country USA
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dc.description.index MEDLINE
dc.identifier.eissn 1750-2659
hcfmusp.citation.scopus 1
hcfmusp.citation.wos 1
hcfmusp.affiliation.country Brasil


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