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https://observatorio.fm.usp.br/handle/OPI/12629
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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | BAILEY, Adam L. | - |
dc.contributor.author | LAUCK, Michael | - |
dc.contributor.author | MOHNS, Mariel | - |
dc.contributor.author | PETERSON, Eric J. | - |
dc.contributor.author | BEHELER, Kerry | - |
dc.contributor.author | BRUNNER, Kevin G. | - |
dc.contributor.author | CROSNO, Kristin | - |
dc.contributor.author | MEJIA, Andres | - |
dc.contributor.author | MUTSCHLER, James | - |
dc.contributor.author | GEHRKE, Matthew | - |
dc.contributor.author | GREENE, Justin | - |
dc.contributor.author | ERICSEN, Adam J. | - |
dc.contributor.author | WEILER, Andrea | - |
dc.contributor.author | LEHRER-BREY, Gabrielle | - |
dc.contributor.author | FRIEDRICH, Thomas C. | - |
dc.contributor.author | SIBLEY, Samuel D. | - |
dc.contributor.author | KALLAS, Esper G. | - |
dc.contributor.author | III, Saverio Capuano | - |
dc.contributor.author | ROGERS, Jeffrey | - |
dc.contributor.author | GOLDBERG, Tony L. | - |
dc.contributor.author | SIMMONS, Heather A. | - |
dc.contributor.author | O'CONNOR, David H. | - |
dc.date.accessioned | 2016-02-11T14:04:26Z | - |
dc.date.available | 2016-02-11T14:04:26Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | SCIENCE TRANSLATIONAL MEDICINE, v.7, n.305, article ID 305ra144, 11p, 2015 | - |
dc.identifier.issn | 1946-6234 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/12629 | - |
dc.description.abstract | Human pegivirus (HPgV)-formerly known as GB virus C and hepatitis G virus-is a poorly characterized RNA virus that infects about one-sixth of the global human population and is transmitted frequently in the blood supply. We create an animal model of HPgV infection by infecting macaque monkeys with a new simian pegivirus (SPgV) discovered in wild baboons. Using this model, we provide a high-resolution, longitudinal picture of SPgV viremia where the dose, route, and timing of infection are known. We detail the highly variable acute phase of SPgV infection, showing that the viral load trajectory early in infection is dependent on the infecting dose, whereas the chronic-phase viremic set point is not. We also show that SPgV has an extremely low propensity for accumulating sequence variation, with no consensus-level variants detected during the acute phase of infection and an average of only 1.5 variants generated per 100 infection-days. Finally, we show that SPgV RNA is highly concentrated in only two tissues: spleen and bone marrow, with bone marrow likely producing most of the virus detected in plasma. Together, these results reconcile several paradoxical observations from cross-sectional analyses of HPgV in humans and provide an animal model for studying pegivirus biology. | - |
dc.description.sponsorship | NIH as part of joint NIH-National Science Foundation Ecology of Infectious Diseases program [TW009237] | - |
dc.description.sponsorship | UK Economic and Social Research Council | - |
dc.description.sponsorship | Wisconsin Partnership Program through Wisconsin Center for Infectious Diseases | - |
dc.description.sponsorship | NIH [R01 AI077376, R01 AI084787] | - |
dc.description.sponsorship | Office of Research Infrastructure Programs [P51 RR000167] | - |
dc.description.sponsorship | Research Facilities Improvement Program [RR15459-01, RR020141-01] | - |
dc.description.sponsorship | University of Wisconsin's Medical Scientist Training Program [T32 GM008692] | - |
dc.description.sponsorship | National Research Service Award through Microbes in Health and Disease training program at the University of Wisconsin [T32 AI55397] | - |
dc.description.sponsorship | National Institute of General Medical Sciences of the NIH [T32GM081061] | - |
dc.language.iso | eng | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.relation.ispartof | Science Translational Medicine | - |
dc.rights | restrictedAccess | - |
dc.subject.other | gb-virus-c | - |
dc.subject.other | hepatitis-g virus | - |
dc.subject.other | c/hepatitis-g virus | - |
dc.subject.other | sexual transmission | - |
dc.subject.other | blood-donors | - |
dc.subject.other | high prevalence | - |
dc.subject.other | down-regulation | - |
dc.subject.other | liver-disease | - |
dc.subject.other | in-vitro | - |
dc.subject.other | rna | - |
dc.title | Durable sequence stability and bone marrow tropism in a macaque model of human pegivirus infection | - |
dc.type | article | - |
dc.rights.holder | Copyright AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.identifier.doi | 10.1126/scitranslmed.aab3467 | - |
dc.identifier.pmid | 26378244 | - |
dc.subject.wos | Cell Biology | - |
dc.subject.wos | Medicine, Research & Experimental | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | BAILEY, Adam L.:Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53711 USA; Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA | - |
hcfmusp.author.external | LAUCK, Michael:Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53711 USA; Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA | - |
hcfmusp.author.external | MOHNS, Mariel:Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53711 USA; Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA | - |
hcfmusp.author.external | PETERSON, Eric J.:Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA | - |
hcfmusp.author.external | BEHELER, Kerry:Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA | - |
hcfmusp.author.external | BRUNNER, Kevin G.:Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA | - |
hcfmusp.author.external | CROSNO, Kristin:Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA | - |
hcfmusp.author.external | MEJIA, Andres:Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA | - |
hcfmusp.author.external | MUTSCHLER, James:Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA; Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53711 USA | - |
hcfmusp.author.external | GEHRKE, Matthew:Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53711 USA; Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA | - |
hcfmusp.author.external | GREENE, Justin:Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53711 USA; Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA | - |
hcfmusp.author.external | ERICSEN, Adam J.:Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53711 USA; Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA | - |
hcfmusp.author.external | WEILER, Andrea:Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA; Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53711 USA | - |
hcfmusp.author.external | LEHRER-BREY, Gabrielle:Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA; Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53711 USA | - |
hcfmusp.author.external | FRIEDRICH, Thomas C.:Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA; Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53711 USA | - |
hcfmusp.author.external | SIBLEY, Samuel D.:Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA; Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53711 USA | - |
hcfmusp.author.external | III, Saverio Capuano:Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA | - |
hcfmusp.author.external | ROGERS, Jeffrey:Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA; Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA | - |
hcfmusp.author.external | GOLDBERG, Tony L.:Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA; Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53711 USA | - |
hcfmusp.author.external | SIMMONS, Heather A.:Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA | - |
hcfmusp.author.external | O'CONNOR, David H.:Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53711 USA; Wisconsin Natl Primate Res Ctr, Madison, WI 53711 USA | - |
hcfmusp.description.articlenumber | 305ra144 | - |
hcfmusp.description.issue | 305 | - |
hcfmusp.description.volume | 7 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000365231800004 | - |
hcfmusp.origem.id | 2-s2.0-84941753926 | - |
hcfmusp.publisher.city | WASHINGTON | - |
hcfmusp.publisher.country | USA | - |
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dc.description.index | MEDLINE | - |
dc.identifier.eissn | 1946-6242 | - |
hcfmusp.citation.scopus | 18 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/60 Artigos e Materiais de Revistas Científicas - ODS/03 |
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