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Please use this identifier to cite or link to this item: https://observatorio.fm.usp.br/handle/OPI/12639
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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP-
dc.contributor.authorPRECIOSO, Alexander Roberto-
dc.contributor.authorPALACIOS, Ricardo-
dc.contributor.authorTHOME, Beatriz-
dc.contributor.authorMONDINI, Gabriella-
dc.contributor.authorBRAGA, Patricia-
dc.contributor.authorKALIL, Jorge-
dc.date.accessioned2016-02-11T14:04:28Z-
dc.date.available2016-02-11T14:04:28Z-
dc.date.issued2015-
dc.identifier.citationVACCINE, v.33, n.50, Special Issue, p.7121-7125, 2015-
dc.identifier.issn0264-410X-
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/12639-
dc.description.abstractButantan Institute is a public Brazilian biomedical research-manufacturer center affiliated to the Sao Paulo State Secretary of Health. Currently, Butantan is one of the main public producers of vaccines, antivenoms, and antitoxins in Latin America. The partnership between Butantan and the National Institutes of Health (NIH) of the United Sates has been one of the longest and most successful partnerships in the development and manufacturing of new vaccines. Recently, Butantan Institute has developed and manufactured a lyophilized tetravalent live attenuated dengue vaccine with the four dengue viruses attenuated and licensed from the Laboratory of Infectious Diseases at The National Institutes of Allergy and Infectious Diseases (LID/NIAID/NIH). The objective of this paper is to describe the clinical evaluation strategies of a live attenuated tetravalent dengue vaccine (Butantan-DV) developed and manufactured by Butantan Institute. These clinical strategies will be used to evaluate the Butantan-DV Phase III trial to support the Butantan-DV licensure for protection against any symptomatic dengue caused by any serotype in people aged 2 to 59 years.-
dc.description.sponsorshipBanco Nacional de Desenvolvimento Economico e Social-BNDES-
dc.language.isoeng-
dc.publisherELSEVIER SCI LTD-
dc.relation.ispartofVaccine-
dc.rightsrestrictedAccess-
dc.subjectTetravalent dengue vaccine-
dc.subjectButantan Institute-
dc.subjectClinical trial-
dc.subject.otherhealthy adult volunteers-
dc.subject.othervirus type-4-
dc.subject.other3'-untranslated region-
dc.subject.othernaive adults-
dc.subject.othercandidates-
dc.subject.othersafe-
dc.subject.othermosquitos-
dc.subject.otherdeletion-
dc.subject.othermonkeys-
dc.titleClinical evaluation strategies for a live attenuated tetravalent dengue vaccine-
dc.typearticle-
dc.rights.holderCopyright ELSEVIER SCI LTD-
dc.identifier.doi10.1016/j.vaccine.2015.09.105-
dc.identifier.pmid26458796-
dc.subject.wosImmunology-
dc.subject.wosMedicine, Research & Experimental-
dc.type.categoryoriginal article-
dc.type.versionpublishedVersion-
hcfmusp.author.externalPALACIOS, Ricardo:Inst Butantan, Div Clin Trials & Pharmacovigilance, BR-05503900 Sao Paulo, Brazil-
hcfmusp.author.externalTHOME, Beatriz:Inst Butantan, Div Clin Trials & Pharmacovigilance, BR-05503900 Sao Paulo, Brazil-
hcfmusp.author.externalMONDINI, Gabriella:Inst Butantan, Div Clin Trials & Pharmacovigilance, BR-05503900 Sao Paulo, Brazil-
hcfmusp.author.externalBRAGA, Patricia:Inst Butantan, Div Clin Trials & Pharmacovigilance, BR-05503900 Sao Paulo, Brazil-
hcfmusp.description.beginpage7121-
hcfmusp.description.endpage7125-
hcfmusp.description.issue50-
hcfmusp.description.issueSpecial Issue-
hcfmusp.description.volume33-
hcfmusp.origemWOS-
hcfmusp.origem.id2-s2.0-84951291942-
hcfmusp.origem.idWOS:000366771500010-
hcfmusp.publisher.cityOXFORD-
hcfmusp.publisher.countryENGLAND-
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dc.description.indexMEDLINE-
dc.identifier.eissn1873-2518-
hcfmusp.citation.scopus38-
hcfmusp.scopus.lastupdate2024-04-12-
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Artigos e Materiais de Revistas Científicas - FM/MCM
Departamento de Clínica Médica - FM/MCM

Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - HC/ICr
Instituto da Criança - HC/ICr

Artigos e Materiais de Revistas Científicas - LIM/19
LIM/19 - Laboratório de Histocompatibilidade e Imunidade Celular

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar


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