Subclinical carotid artery atherosclerosis and performance on cognitive tests in middle-aged adults: Baseline results from the ELSA-Brasil

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author SUEMOTO, Claudia K. FMUSP-HC
SANTOS, Itamar S. FMUSP-HC
BITTENCOURT, Marcio S. FMUSP-HC
PEREIRA, Alexandre C. FMUSP-HC
GOULART, Alessandra C. FMUSP-HC
RUNDEK, Tatjana
PASSOS, Valeria M.
LOTUFO, Paulo FMUSP-HC
BENSENOR, Isabela M. FMUSP-HC
dc.date.issued 2015
dc.identifier.citation ATHEROSCLEROSIS, v.243, n.2, p.510-515, 2015
dc.identifier.issn 0021-9150
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/12642
dc.description.abstract Background and aims: Carotid artery intima-media thickness (CIMT) may be used as a biomarker for early cognitive impairment. However, the results of the association between CIMT and cognitive function in middle-aged subjects are mixed. We aimed to investigate this association in a large Brazilian sample with no history of stroke at baseline. Additionally, we tested the effect of interactions between CIMT and cardiovascular risk factors on cognitive performance. Methods: In this cross-sectional study, cognition was evaluated using the delayed word recall (DWRT), the category fluency, and the trail making tests (TMT). CIMT was measured at the common carotid artery. The association between CIMT and cognitive tests was investigated using linear regression models, adjusted for an extensive set of possible confounding variables. We also included interaction terms with selected risk factors. Results: The mean age of the 8208 participants was 49.6 +/- 7.3 years, 44% were male, and 56% White. Increase in CIMT was associated with worse performance on the DWRT (beta = -0.433, 95% CI = -0.724; -0.142, p = 0.004). We found effect modification of the association between cognitive function and CMIT by self-reported heart failure and alcohol intake. Participants had worse performance in the TMT if they had greater CIMT and current alcohol use (p < 0.0001). The interaction between CIMT and heart failure on TMT performance was not significant after adjustment for multiple comparisons (p = 0.07). Conclusions: In this sample of middle-aged adults, CIMT was inversely associated with memory function. Additionally, the presence of alcohol use resulted in a stronger association of CIMT with worse performance on an executive function test.
dc.description.sponsorship · Brazilian Ministry of Health
· CNPq [01060010.00RS, 01060212.00BA, 01060300.00ES, 01060278.00MG, 01060115.00SP, 01060071.00RJ]
· CAPES
dc.language.iso eng
dc.publisher ELSEVIER IRELAND LTD
dc.relation.ispartof Atherosclerosis
dc.rights restrictedAccess
dc.subject Carotid intima media thickness; Atherosclerosis; Cognition disorders
dc.subject.other intima-media thickness; vascular risk-factors; alzheimers-disease; cardiovascular-disease; older-adults; dementia; impairment; health; decline; cerad
dc.title Subclinical carotid artery atherosclerosis and performance on cognitive tests in middle-aged adults: Baseline results from the ELSA-Brasil
dc.type article
dc.rights.holder Copyright ELSEVIER IRELAND LTD
dc.description.group LIM/13
dc.description.group LIM/20
dc.description.group LIM/22
dc.description.group LIM/51
dc.identifier.doi 10.1016/j.atherosclerosis.2015.10.008
dc.identifier.pmid 26520907
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author SUEMOTO, Claudia K.:FM:MCM
hcfmusp.author SANTOS, Itamar S.:FM:MCM
hcfmusp.author BITTENCOURT, Marcio S.:HC:ICESP
hcfmusp.author PEREIRA, Alexandre C.:HC:INCOR
hcfmusp.author GOULART, Alessandra C.:HU:SCPACEX-62
hcfmusp.author LOTUFO, Paulo:FM:MCM
hcfmusp.author BENSENOR, Isabela M.:FM:MCM
hcfmusp.author.external · RUNDEK, Tatjana:Univ Miami, Miller Sch Med, Dept Neurol Sci, Miami, FL 33136 USA; Univ Miami, Miller Sch Med, Dept Publ Hlth Sci, Miami, FL 33136 USA
· PASSOS, Valeria M.:Univ Fed Minas Gerais, Sch Med, Dept Internal Med, Belo Horizonte, MG, Brazil
hcfmusp.origem.id 2-s2.0-84946212412
hcfmusp.origem.id WOS:000366534100023
hcfmusp.publisher.city CLARE
hcfmusp.publisher.country IRELAND
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dc.description.index MEDLINE
dc.identifier.eissn 1879-1484
hcfmusp.citation.scopus 9
hcfmusp.citation.wos 9
hcfmusp.affiliation.country Brasil
hcfmusp.affiliation.country Estados Unidos


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