https://observatorio.fm.usp.br/handle/OPI/12721
Title: | Neuropathic pain after brachial plexus avulsion - central and peripheral mechanisms |
Authors: | TEIXEIRA, Manoel Jacobsen; PAZ, Matheus Gomes da S. da; BINA, Mauro Tupiniquim; SANTOS, Scheila Nogueira; RAICHER, Irina; GALHARDONI, Ricardo; FERNANDES, Diego Toledo; YENG, Lin T.; BAPTISTA, Abrahao F.; ANDRADE, Daniel Ciampi De |
Citation: | BMC NEUROLOGY, v.15, article ID 73, 9p, 2015 |
Abstract: | Review: The pain that commonly occurs after brachial plexus avulsion poses an additional burden on the quality of life of patients already impaired by motor, sensory and autonomic deficits. Evidence-based treatments for the pain associated with brachial plexus avulsion are scarce, thus frequently leaving the condition refractory to treatment with the standard methods used to manage neuropathic pain. Unfortunately, little is known about the pathophysiology of brachial plexus avulsion. Available evidence indicates that besides primary nerve root injury, central lesions related to the abrupt disconnection of nerve roots from the spinal cord may play an important role in the genesis of neuropathic pain in these patients and may explain in part its refractoriness to treatment. Conclusions: The understanding of both central and peripheral mechanisms that contribute to the development of pain is of major importance in order to propose more effective treatments for brachial plexus avulsion-related pain. This review focuses on the current understanding about the occurrence of neuropathic pain in these patients and the role played by peripheral and central mechanisms that provides insights into its treatment. Summary: Pain after brachial plexus avulsion involves both peripheral and central components; thereby it is characterized as a mixed (central and peripheral) neuropathic pain syndrome. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MNE Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/IOT Artigos e Materiais de Revistas Científicas - HC/IPq Artigos e Materiais de Revistas Científicas - LIM/26 Artigos e Materiais de Revistas Científicas - LIM/45 |
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art_TEIXEIRA_Neuropathic_pain_after_brachial_plexus_avulsion_central_and_2015.PDF | publishedVersion (English) | 621.46 kB | Adobe PDF | View/Open |
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