Comorbidity variation in patients with obsessive-compulsive disorder according to symptom dimensions: Results from a large multicentre clinical sample

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art_TORRES_Comorbidity_variation_in_patients_with_obsessivecompulsive_disorder_according_2016.PDF (347.47 KB)
Citações na Scopus
77
Tipo de produção
article
Data de publicação
2016
Editora
ELSEVIER SCIENCE BV
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
TORRES, Albina R.
FONTENELLE, Leonardo E.
FERRAO, Ygor A.
ROSARIO, Maria Conceicao do
STORCH, Eric A.
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
JOURNAL OF AFFECTIVE DISORDERS, v.190, p.508-516, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Obsessive-compulsive disorder (OCD) has a heterogeneous and complex phenomenological picture, characterized by different symptom dimensions and comorbid psychiatric disorders, which frequently co-occur or are replaced by others over the illness course. To date, very few studies have investigated the associations between specific OCD symptom dimensions and comorbid disorders. Methods: Cross-sectional, multicenter clinical study with 1001 well-characterized OCD patients recruited within the Brazilian Research Consortium on Obsessive-Compulsive and Related Disorders. The primary instruments were the Dimensional Yale-Brown Obsessive Compulsive Scale (DY-BOCS) and the Structured Clinical Interview for DSM-IV Axis I Disorders. Bivariate analyses between symptom dimensions and comorbidities were followed by logistic regression. Results: The most common comorbidities among participants (56.8% females) were major depression (56.4%), social phobia (34.6%), generalized anxiety disorder (34.3%), and specific phobia (31.4%). The aggressive dimension was independently associated with posttraumatic stress disorder (PTSD), separation anxiety disorder, any impulse-control disorder and skin picking; the sexual-religious dimension was associated with mood disorders, panic disorder/agoraphobia, social phobia, separation anxiety disorder, non-paraphilic sexual disorder, any somatoform disorder, body dysmorphic disorder and tic disorders; the contamination-cleaning dimension was related to hypochondriasis; and the hoarding dimension was associated with depressive disorders, specific phobia, PTSD, impulse control disorders (compulsive buying, skin picking, internet use), ADHD and tic disorders. The symmetry-ordering dimension was not independently associated with any comorbidity. Limitations: Cross-sectional design; participants from only tertiary mental health services; personality disorders not investigated. Conclusions: Different OCD dimensions presented some specific associations with comorbid disorders, which may influence treatment seeking behaviors and response, and be suggestive of different underlying pathogenic mechanisms.
Palavras-chave
Obsessive-compulsive disorder, Symptom dimensions, Comorbidity, Comorbid disorders
URI
https://observatorio.fm.usp.br/handle/OPI/12767
Referências
  1. Frost RO, 2009, J ANXIETY DISORD, V23, P632, DOI 10.1016/j.janxdis.2009.01.013
  2. Lochner C, 2014, COMPR PSYCHIAT, V55, P1513, DOI 10.1016/j.comppsych.2014.05.020
  3. Grant JE, 2006, COMPR PSYCHIAT, V47, P325, DOI 10.1016/j.comppsych.2006.01.007
  4. Mataix-Cols D, 2002, PSYCHOTHER PSYCHOSOM, V71, P255, DOI 10.1159/000064812
  5. Kalra H, 2008, COMPR PSYCHIAT, V49, P51, DOI 10.1016/j.comppsych.2007.08.005
  6. Janowitz D, 2009, DEPRESS ANXIETY, V26, P1012, DOI 10.1002/da.20597
  7. Fontenelle LF, 2004, COMPR PSYCHIAT, V45, P375, DOI 10.1016/j.comppsych.2004.03.005
  8. Mataix-Cols D, 1999, AM J PSYCHIAT, V156, P1409
  9. Hasler G, 2005, PSYCHIAT RES, V135, P121, DOI 10.1016/j.psychres.2005.03.003
  10. Grisham JR, 2008, EUR ARCH PSY CLIN N, V258, P107, DOI 10.1007/s00406-007-0789-0
  11. Rufer M, 2005, J AFFECT DISORDERS, V88, P99, DOI 10.1016/j.jad.2005.06.003
  12. Hartl TL, 2005, BEHAV RES THER, V43, P269, DOI 10.1016/j.brat.2004.02.002
  13. LaSalle-Ricci VH, 2006, BEHAV RES THER, V44, P1503, DOI 10.1016/j.brat.2005.11.009
  14. Hall BJ, 2013, DEPRESS ANXIETY, V30, P67, DOI 10.1002/da.22015
  15. Fullana MA, 2009, AM J PSYCHIAT, V166, P329, DOI [10.1176/appi.ajp.2008.08071006, 10.1176/appi.ajp.2008/08071006]
  16. Mroczkowski MM, 2011, DEPRESS ANXIETY, V28, P256, DOI 10.1002/da.20773
  17. Mataix-Cols D, 2005, AM J PSYCHIAT, V162, P228, DOI 10.1176/appi.ajp.162.2.228
  18. Timpano KR, 2014, BEHAV THER, V45, P690, DOI 10.1016/j.beth.2014.04.002
  19. Roberson-Nay R, 2012, DEPRESS ANXIETY, V29, P320, DOI 10.1002/da.21931
  20. Shavitt R, 2010, EUR ARCH PSY CLIN N, V260, P91, DOI 10.1007/s00406-009-0015-3
  21. Torres AR, 2011, J CLIN PSYCHIAT, V72, P17, DOI 10.4088/JCP.09m05651blu
  22. de la Cruz LF, 2013, DEPRESS ANXIETY, V30, P732, DOI 10.1002/da.22097
  23. Mataix-Cols D, 2004, ARCH GEN PSYCHIAT, V61, P564, DOI 10.1001/archpsyc.61.6.564
  24. Miguel EC, 1997, BRIT J PSYCHIAT, V170, P140, DOI 10.1192/bjp.170.2.140
  25. LaSalle VH, 2004, DEPRESS ANXIETY, V19, P163, DOI 10.1002/da.20009
  26. Denys D, 2004, J AFFECT DISORDERS, V80, P155, DOI 10.1016/S0165-0327(03)00056-9
  27. Amerio A, 2014, ACTA PSYCHIAT SCAND, V129, P343, DOI 10.1111/acps.12250
  28. de Mathis MA, 2009, CNS SPECTRUMS, V14, P362
  29. Ferrao YA, 2006, J AFFECT DISORDERS, V94, P199, DOI 10.1016/j.jad.2006.04.019
  30. Bulli F, 2014, BEHAV COGN PSYCHOTH, V42, P297, DOI 10.1017/S1352465812001105
  31. Tukel R, 2002, COMPR PSYCHIAT, V43, P204, DOI 10.1053/comp.2002.32355
  32. Wheaton M, 2008, J ANXIETY DISORD, V22, P243, DOI 10.1016/j.janxdis.2007.01.015
  33. Frost RO, 2011, DEPRESS ANXIETY, V28, P876, DOI 10.1002/da.20861
  34. Adam Y, 2012, SOC PSYCH PSYCH EPID, V47, P339, DOI 10.1007/s00127-010-0337-5
  35. Fontenelle LF, 2012, J ANXIETY DISORD, V26, P377, DOI 10.1016/j.janxdis.2011.12.001
  36. Winsberg ME, 1999, J CLIN PSYCHIAT, V60, P591
  37. Hasler G, 2007, BIOL PSYCHIAT, V61, P617, DOI 10.1016/j.biopsych.2006.05.040
  38. Nestadt G, 2009, PSYCHOL MED, V39, P1491, DOI 10.1017/S0033291708004753
  39. Zlotnick C, 1999, J NERV MENT DIS, V187, P296, DOI 10.1097/00005053-199905000-00005
  40. Batmaz S, 2013, COMPR PSYCHIAT, V54, P740, DOI 10.1016/j.comppsych.2013.02.004
  41. Jakubovski E, 2013, DEPRESS ANXIETY, V30, P763, DOI 10.1002/da.22013
  42. Mueller A, 2009, BEHAV RES THER, V47, P705, DOI 10.1016/j.brat.2009.04.005
  43. Caspi A, 2008, ISR J PSYCHIATR REL, V45, P177
  44. Chacon P, 2007, AM J MED GENET B, V144B, P551, DOI 10.1002/ajmg.b.30457
  45. Grisham JR, 2007, BEHAV RES THER, V45, P1471, DOI 10.1016/j.brat.2006.12.008
  46. Leckman JF, 1997, AM J PSYCHIAT, V154, P911
  47. Coles ME, 2003, BEHAV RES THER, V41, P179, DOI 10.1016/S0005-7967(01)00136-X
  48. Chakraborty V, 2012, COMPR PSYCHIAT, V53, P1153, DOI 10.1016/j.comppsych.2012.05.006
  49. Samuels J, 2002, BEHAV RES THER, V40, P517, DOI 10.1016/S0005-7967(01)00026-2
  50. Raffin AL, 2009, EUR PSYCHIAT, V24, P297, DOI 10.1016/j.eurpsy.2008.12.001
  51. Via E, 2014, BRIT J PSYCHIAT, V204, P61, DOI 10.1192/bjp.bp.112.123364
  52. Ruscio AM, 2010, MOL PSYCHIATR, V15, P53, DOI 10.1038/mp.2008.94
  53. Fullana MA, 2007, BEHAV MODIF, V31, P815, DOI 10.1177/0145445507301649
  54. Bloch MH, 2008, AM J PSYCHIAT, V165, P1532, DOI 10.1176/appi.ajp.2008.08020320
  55. Fineberg NA, 2013, INT J PSYCHIAT CLIN, V17, P188, DOI 10.3109/13651501.2013.777745
  56. van den Heuvel OA, 2009, BRAIN, V132, P853, DOI 10.1093/brain/awn267
  57. Hofmeijer-Sevink MK, 2013, J AFFECT DISORDERS, V150, P847, DOI 10.1016/j.jad.2013.03.014
  58. Tolin DF, 2011, BEHAV RES THER, V49, P120, DOI 10.1016/j.brat.2010.12.002
  59. Torres AR, 2006, AM J PSYCHIAT, V163, P1978, DOI 10.1176/appi.ajp.163.11.1978
  60. Rosario-Campos MC, 2006, MOL PSYCHIATR, V11, P495, DOI 10.1038/sj.mp.4001798
  61. Rucci P, 2009, J PSYCHIATR RES, V43, P366, DOI 10.1016/j.jpsychires.2008.04.002
  62. de Mathis MA, 2013, EUR NEUROPSYCHOPHARM, V23, P594, DOI 10.1016/j.euroneuro.2012.08.006
  63. Brakoulias V, 2013, COMPR PSYCHIAT, V54, P750, DOI 10.1016/j.comppsych.2013.02.005
  64. Samuels J, 2007, AM J PSYCHIAT, V164, P493, DOI 10.1176/appi.ajp.164.3.493
  65. Coffey BJ, 1998, J NERV MENT DIS, V186, P201, DOI 10.1097/00005053-199804000-00001
  66. Borges CP, 2011, PSYCHOTHER PSYCHOSOM, V80, P249, DOI 10.1159/000322028
  67. Cerda M, 2008, EPIDEMIOL REV, V30, P155, DOI 10.1093/epirev/mxn003
  68. Frank H, 2014, J OBSESS-COMPULS REL, V3, P6, DOI 10.1016/j.jocrd.2013.11.001
  69. Harrison BJ, 2013, BIOL PSYCHIAT, V73, P321, DOI 10.1016/j.biopsych.2012.10.006
  70. BAER L, 1994, J CLIN PSYCHIAT, V55, P18
  71. First M., 1995, STRUCTURED CLIN INTE
  72. First M.B., 2004, STRUCTURAL CLIN INTE
  73. Gomes dA, 2012, CNS SPECTRUMS, V17, P87
  74. GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1012
  75. Ha T.H., 2004, J KOREAN NEUROPSYCHI, V43, P46
  76. Hacker L.E., 2012, J ATTEN DISORD
  77. Landeros-Weisenberger A, 2010, J AFFECT DISORDERS, V121, P175, DOI 10.1016/j.jad.2009.06.010
  78. McGuire JF, 2014, DEPRESS ANXIETY, V31, P988, DOI 10.1002/da.22241
  79. Miguel E.C., 2008, REV BRAS PSIQUIATR, V30, P187
  80. Pigott T.A., 1994, J CLIN PSYCHIAT S, V55, pS15
  81. Samuels J, 2014, J OBSESS-COMPULS REL, V3, P325, DOI 10.1016/j.jocrd.2014.08.001
  82. Stata Corporation, 2011, STAT STAT SOFTW REL
  83. Storch A.L., 2007, COMPR PSYCHIAT, V48, P313

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/21