https://observatorio.fm.usp.br/handle/OPI/12778
Title: | A Longitudinal (6-week) 3T H-1-MRS Study on the Effects of Lithium Treatment on Anterior Cingulate Cortex Metabolites in Bipolar Depression |
Authors: | MACHADO-VIEIRA, Rodrigo; GATTAZ, Wagner F.; ZANETTI, Marcus V.; SOUSA, Rafael T. De; CARVALHO, Andre F.; SOEIRO-DE-SOUZA, Marcio G.; LEITE, Claudia C.; OTADUY, Maria C. |
Citation: | EUROPEAN NEUROPSYCHOPHARMACOLOGY, v.25, n.12, p.2311-2317, 2015 |
Abstract: | The anterior cingulate cortex (ACC) is a key area in mood regulation. To date, no Longitudinal study has specifically evaluated lithium's effects on ACC metabolites using H-1-MRS, as well as its association with clinical improvement in bipolar depression. This H-1-MRS (TE=35 ms) study evaluated 24 drug-free BD patients during depressive episodes and after lithium treatment at therapeutic levels. Brain metabolite levels (N-acetyl aspartate (NM), creatine (tCr), choline, myo-inositol, and glutamate levels) were measured in the ACC at baseline (week 0) and after lithium monotherapy (week 6). The present investigation showed that ACC glutamate (Glu/tCr) and glutamate +glutamine (Glx/tCr) significantly increased after six weeks of lithium therapy. Regarding the association with clinical improvement, remitters showed an increase in myoinositol levels (ml/tCr) after lithium treatment compared to non-remitters. The present findings reinforce a role for ACC glutamate-glutamine cycling and myoinositol pathway as key targets for lithium's therapeutic effects in BD. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MDR Artigos e Materiais de Revistas Científicas - FM/MPS Artigos e Materiais de Revistas Científicas - HC/InRad Artigos e Materiais de Revistas Científicas - HC/IPq Artigos e Materiais de Revistas Científicas - LIM/21 Artigos e Materiais de Revistas Científicas - LIM/23 Artigos e Materiais de Revistas Científicas - LIM/27 Artigos e Materiais de Revistas Científicas - LIM/44 |
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