Neural and mesenchymal stem cells in animal models of Huntington's disease: past experiences and future challenges
Carregando...
Citações na Scopus
34
Tipo de produção
article
Data de publicação
2015
Editora
BIOMED CENTRAL LTD
Indexadores
Título da Revista
ISSN da Revista
Título do Volume
Autores
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
STEM CELL RESEARCH & THERAPY, v.6, article ID 232, 15p, 2015
Resumo
Huntington's disease (HD) is an inherited disease that causes progressive nerve cell degeneration. It is triggered by a mutation in the HTT gene that strongly influences functional abilities and usually results in movement, cognitive and psychiatric disorders. HD is incurable, although treatments are available to help manage symptoms and to delay the physical, mental and behavioral declines associated with the condition. Stem cells are the essential building blocks of life, and play a crucial role in the genesis and development of all higher organisms. Ablative surgical procedures and fetal tissue cell transplantation, which are still experimental, demonstrate low rates of recovery in HD patients. Due to neuronal cell death caused by accumulation of the mutated huntingtin (mHTT) protein, it is unlikely that such brain damage can be treated solely by drug-based therapies. Stem cell-based therapies are important in order to reconstruct damaged brain areas in HD patients. These therapies have a dual role: stem cell paracrine action, stimulating local cell survival, and brain tissue regeneration through the production of new neurons from the intrinsic and likely from donor stem cells. This review summarizes current knowledge on neural stem/progenitor cell and mesenchymal stem cell transplantation, which has been carried out in several animal models of HD, discussing cell distribution, survival and differentiation after transplantation, as well as functional recovery and anatomic improvements associated with these approaches. We also discuss the usefulness of this information for future preclinical and clinical studies in HD.
Palavras-chave
Referências
- Vazey EM, 2006, EXP NEUROL, V199, P384, DOI 10.1016/j.expneurol.2006.01.034
- Tai YF, 2007, BRAIN, V130, P1759, DOI 10.1093/brain/awm044
- Lee ST, 2005, NEUROSCI RES, V52, P243, DOI 10.1016/j.neures.2005.03.016
- Owens T, 2008, J NEUROPATH EXP NEUR, V67, P1113, DOI 10.1097/NEN.0b013e31818f9ca8
- Crigler L, 2006, EXP NEUROL, V198, P54, DOI 10.1016/j.expneurol.2005.10.029
- Caplan AI, 2011, CELL STEM CELL, V9, P11, DOI 10.1016/j.stem.2011.06.008
- Beal MF, 2004, NAT REV NEUROSCI, V5, P373, DOI 10.1038/nrn1386
- Chen SF, 2004, CHINESE MED J-PEKING, V117, P1443
- Dragatsis I, 2000, NAT GENET, V26, P300
- Walker FO, 2007, LANCET, V369, P218, DOI 10.1016/S0140-6736(07)60111-1
- Griffin MD, 2013, IMMUNOL CELL BIOL, V91, P40, DOI 10.1038/icb.2012.67
- Bianco P, 2013, NAT MED, V19, P35, DOI 10.1038/nm.3028
- Kharaziha P, 2009, EUR J GASTROEN HEPAT, V21, P1199, DOI 10.1097/MEG.0b013e32832a1f6c
- Kokaia Z, 2012, NAT NEUROSCI, V15, P1078, DOI 10.1038/nn.3163
- Lee JM, 2015, CELL, V162, P516, DOI 10.1016/j.cell.2015.07.003
- Bachoud-Levi AC, 2006, LANCET NEUROL, V5, P303, DOI 10.1016/S1474-4422(06)
- Wild EJ, 2015, J CLIN INVEST, V125, P1979, DOI 10.1172/JCI80743
- Reyes S, 2015, EXPERT REV NEUROTHER, V15, P381, DOI 10.1586/14737175.2015.1021787
- Rosenblatt A, 2012, MOVEMENT DISORD, V27, P272, DOI 10.1002/mds.24024
- Ryu JK, 2004, NEUROBIOL DIS, V16, P68, DOI 10.1016/j.nbd.2004.01.016
- Kahlem P, 1996, P NATL ACAD SCI USA, V93, P14580, DOI 10.1073/pnas.93.25.14580
- English K, 2013, IMMUNOL CELL BIOL, V91, P19, DOI 10.1038/icb.2012.56
- MULLEN RJ, 1992, DEVELOPMENT, V116, P201
- Zhang RL, 2003, NEUROSCIENCE, V116, P373, DOI 10.1016/S0306-4522(02)00696-6
- Maucksch C, 2013, J CELL BIOCHEM, V114, P754, DOI 10.1002/jcb.24432
- Soulet D, 2011, MOL PSYCHIATR, V16, P889, DOI 10.1038/mp.2011.28
- Martindale D, 1998, NAT GENET, V18, P150, DOI 10.1038/ng0298-150
- Schilling G, 1999, HUM MOL GENET, V8, P397, DOI 10.1093/hmg/8.3.397
- Ellrichmann G, 2013, CLIN DEV IMMUNOL, DOI 10.1155/2013/541259
- Honmou O, 2012, TRENDS MOL MED, V18, P292, DOI 10.1016/j.molmed.2012.02.003
- SUBRAMANIAN T, 1995, EXP NEUROL, V131, P157, DOI 10.1016/0014-4886(95)90017-9
- Augello A, 2005, EUR J IMMUNOL, V35, P1482, DOI 10.1002/eji.200425405
- Fainstein N, 2008, MOL CELL NEUROSCI, V39, P335, DOI 10.1016/j.mcn.2008.07.007
- Yoo SW, 2013, NEUROBIOL DIS, V58, P249, DOI 10.1016/j.nbd.2013.06.001
- SHARP AH, 1995, NEURON, V14, P1065, DOI 10.1016/0896-6273(95)90345-3
- KREMER HPH, 1990, J NEUROPATH EXP NEUR, V49, P371, DOI 10.1097/00005072-199007000-00002
- Vazey EM, 2010, CELL TRANSPLANT, V19, P1055, DOI 10.3727/096368910X494632
- Kordower JH, 1996, J COMP NEUROL, V370, P203
- Tan Z, 2015, MOL PSYCHIATR, V20, P1286, DOI 10.1038/mp.2015.81
- Ankrum JA, 2014, NAT BIOTECHNOL, V32, P252, DOI 10.1038/nbt.2816
- ZEITLIN S, 1995, NAT GENET, V11, P155, DOI 10.1038/ng1095-155
- Vonsattel JPG, 1998, J NEUROPATH EXP NEUR, V57, P369
- Koellensperger E, 2014, J PLAST RECONSTR AES, V67, P844, DOI 10.1016/j.bjps.2014.02.021
- Bjorkqvist M, 2008, J EXP MED, V205, P1869, DOI 10.1084/jem.20080178
- LANGE H, 1976, J NEUROL SCI, V28, P401, DOI 10.1016/0022-510X(76)90114-3
- Ivkovic S, 1999, J NEUROSCI, V19, P5409
- Landles C, 2004, EMBO REP, V5, P958, DOI 10.1038/sj.embor.7400250
- Cicchetti F, 2014, ANN NEUROL, V76, P31, DOI 10.1002/ana.24174
- Le Blanc K, 2006, CURR OPIN IMMUNOL, V18, P586, DOI 10.1016/j.coi.2006.07.004
- Baquet ZC, 2004, J NEUROSCI, V24, P4250, DOI 10.1523/JNEUROSCI.3920-03.2004
- Dore-Duffy P, 2006, J CEREBR BLOOD F MET, V26, P613, DOI 10.1038/sj.jcbfm.9600272
- Klempir J, 2011, MOVEMENT DISORD, V26, P125, DOI 10.1002/mds.23436
- Leavitt BR, 2001, AM J HUM GENET, V68, P313, DOI 10.1086/318207
- NASIR J, 1995, CELL, V81, P811, DOI 10.1016/0092-8674(95)90542-1
- Klassen H, 2003, VISION RES, V43, P947, DOI 10.1016/S0042-6989(03)00094-4
- Kazantsev A, 1999, P NATL ACAD SCI USA, V96, P11404, DOI 10.1073/pnas.96.20.11404
- Lee ST, 2006, J NEUROSCI METH, V152, P250, DOI 10.1016/j.jneumeth.2005.09.013
- Tse WT, 2003, TRANSPLANTATION, V75, P389, DOI 10.1097/01.TP.0000045055.63901.A9
- SANBERG PR, 1981, EUR J PHARMACOL, V74, P347, DOI 10.1016/0014-2999(81)90054-6
- Joyce N, 2010, REGEN MED, V5, P933, DOI [10.2217/rme.10.72, 10.2217/RME.10.72]
- Marconi S, 2012, TISSUE ENG PT A, V18, P1264, DOI [10.1089/ten.TEA.2011.0491, 10.1089/ten.tea.2011.0491]
- Ross CA, 2011, LANCET NEUROL, V10, P83, DOI 10.1016/S1474-4422(10)70245-3
- Dominici M, 2006, CYTOTHERAPY, V8, P315, DOI 10.1080/14653240600855905
- Lee JM, 2012, NEUROLOGY, V78, P690, DOI 10.1212/WNL.0b013e318249f683
- Ha AD, 2012, CURR OPIN NEUROL, V25, P491, DOI 10.1097/WCO.0b013e3283550c97
- Messina C, 2008, BONE MARROW TRANSPL, V41, pS65, DOI 10.1038/bmt.2008.57
- DiFiglia M, 1997, SCIENCE, V277, P1990, DOI 10.1126/science.277.5334.1990
- Rossignol J, 2011, BEHAV BRAIN RES, V217, P369, DOI 10.1016/j.bbr.2010.11.006
- Dalrymple A, 2007, J PROTEOME RES, V6, P2833, DOI 10.1021/pr0700753
- Johann V, 2007, EXP BRAIN RES, V177, P458, DOI 10.1007/s00221-006-0689-y
- Zuccato C, 2005, PHARMACOL RES, V52, P133, DOI 10.1016/j.phrs.2005.01.001
- Caplan AI, 2006, J CELL BIOCHEM, V98, P1076, DOI 10.1002/jcb.20886
- Xie YX, 2010, J NEUROSCI, V30, P14708, DOI 10.1523/JNEUROSCI.1637-10.2010
- TROTTIER Y, 1995, NATURE, V378, P403, DOI 10.1038/378403a0
- VENTIMIGLIA R, 1995, EUR J NEUROSCI, V7, P213, DOI 10.1111/j.1460-9568.1995.tb01057.x
- Yang CR, 2009, J NEUROSCI RES, V87, P26, DOI 10.1002/jnr.21817
- Walling HW, 1998, J NEUROSCI RES, V54, P301, DOI 10.1002/(SICI)1097-4547(19981101)54:3<301::AID-JNR1>3.0.CO;2-W
- Bantubungi K, 2008, MOL CELL NEUROSCI, V37, P454, DOI 10.1016/j.mcn.2007.11.001
- Kassubek J, 2004, J NEUROL NEUROSUR PS, V75, P213
- Pittenger MF, 1999, SCIENCE, V284, P143, DOI 10.1126/science.284.5411.143
- Engelhardt B, 2009, SEMIN IMMUNOPATHOL, V31, P497, DOI 10.1007/s00281-009-0177-0
- Bennett EJ, 2007, NATURE, V448, P704, DOI 10.1038/nature06022
- Jeon D, 2011, EPILEPSIA, V52, P1617, DOI 10.1111/j.1528-1167.2011.03182.x
- Ramaswamy S, 2007, ILAR J, V48, P356
- Wilkins A, 2009, STEM CELL RES, V3, P63, DOI 10.1016/j.scr.2009.02.006
- Matsushita T, 2011, NEUROSCI LETT, V502, P41, DOI 10.1016/j.neulet.2011.07.021
- Petersen A, 2005, HUM MOL GENET, V14, P39, DOI 10.1093/hmg/ddi004
- Roberts TJ, 2006, NEUROSCIENCE, V139, P1187, DOI 10.1016/j.neuroscience.2006.01.025
- Einstein O, 2008, ARCH NEUROL-CHICAGO, V65, P452, DOI 10.1001/archneur.65.4.452
- Mastrokolias A, 2015, EUR J HUM GENET, V23, P1349, DOI 10.1038/ejhg.2014.281
- Heinsen H, 1996, ACTA NEUROPATHOL, V91, P161
- Moraes L, 2012, STEM CELL RES, V9, P143, DOI 10.1016/j.scr.2012.05.005
- Barker RA, 2013, J NEUROL NEUROSUR PS, V84, P657, DOI 10.1136/jnnp-2012-302441
- McBride JL, 2004, J COMP NEUROL, V475, P211, DOI 10.1002/cne.20176
- Lee ST, 2009, ANN NEUROL, V66, P671, DOI 10.1002/ana.21788
- Trushina E, 2004, MOL CELL BIOL, V24, P8195, DOI 10.1128/MCB.24.18.8195-8209.2004
- Dong XX, 2009, ACTA PHARMACOL SIN, V30, P379, DOI 10.1038/aps.2009.24
- Richardson RM, 2005, MOL CELL NEUROSCI, V28, P674, DOI 10.1016/j.mcn.2004.11.013
- Le Blanc K, 2003, EXP HEMATOL, V31, P890, DOI 10.1016/S0301-472X(03)00110-3
- Aggarwal S, 2005, BLOOD, V105, P1815, DOI 10.1182/blood-2004-04-1559
- Danielyan L, 2009, EUR J CELL BIOL, V88, P315, DOI 10.1016/j.ejcb.2009.02.001
- Reekmans KP, 2011, CELL TRANSPLANT, V20, P851, DOI 10.3727/096368910X543411
- Weiss A, 2012, J CLIN INVEST, V122, P3731, DOI 10.1172/JCI64565
- Guillemin GJ, 2012, FEBS J, V279, P1356, DOI 10.1111/j.1742-4658.2012.08485.x
- Paulsen JS, 2008, J NEUROL NEUROSUR PS, V79, P874, DOI 10.1136/jnnp.2007.128728
- Mangiarini L, 1996, CELL, V87, P493, DOI 10.1016/S0092-8674(00)81369-0
- De Miguel MP, 2012, CURR MOL MED, V12, P574
- Petersen A, 2001, HUM MOL GENET, V10, P1243, DOI 10.1093/hmg/10.12.1243
- Papp KV, 2011, BRAIN COGNITION, V77, P280, DOI 10.1016/j.bandc.2011.07.009
- Hare JM, 2009, J AM COLL CARDIOL, V54, P2277, DOI 10.1016/j.jacc.2009.06.055
- Li SH, 2004, TRENDS GENET, V20, P146, DOI 10.1016/j.tig.2004.01.008
- Gomi M, 2011, J NEUROSCI RES, V89, P1388, DOI 10.1002/jnr.22667
- Barzilay R, 2011, TRANSL PSYCHIAT, V1, DOI 10.1038/tp.2011.64
- Bruner DW, 2012, AM SOC CLIN ONCOL ED, V2012, P139
- Caplan AI, 2015, MENOPAUSE, V22, P131, DOI [10.1097/GME.0000000000000408, 10.1097/gme.0000000000000408]
- Caplan AI, 2004, HDB STEM CELLS, P299
- Chen J, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0075682
- Cisbani G, 2012, CELL DEATH DIS, V3, DOI 10.1038/cddis.2012.121
- DUYAO MP, 1995, SCIENCE, V269, P407, DOI 10.1126/science.7618107
- Fink KD, 2013, STEM CELL RES THER, V4, DOI 10.1186/scrt341
- HARPER PS, 1992, HUM GENET, V89, P365
- Harper PS, 2006, ELS, DOI 10.1038/npg.els.0005150
- Hunt V P, 1989, J Neurosci Nurs, V21, P92
- Kerkis I, 2008, J TRANSL MED, V6, DOI 10.1186/1479-5876-6-35
- Kim S, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0045757
- Lin YT, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022924
- Liu L, 2013, STEM CELLS INT, V2013, DOI 10.1155/2013/435093
- Murphy MB, 2013, EXP MOL MED, V45, DOI 10.1038/emm.2013.94
- Scheuing L, 2014, INT J BIOL SCI, V10, P1024, DOI 10.7150/ijbs.9898
- Singer NG, 2014, ANNU REV PATHOL-MECH, V6, P457
- Snyder BR, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0009347
- Trager U., 2014, NEUROBIOL DIS C, V73C, P388, DOI 10.1016/J.NBD.2014.10.012
- Trager U, 2013, PLOS CURR, P5, DOI 10.1371/currents.hd.5791c897b5c3bebeed93b1d1da0c0648
- Wild Edward, 2008, Expert Rev Neurother, V8, P1779, DOI 10.1586/14737175.8.12.1779
- Zhang R, 2013, J NEUROINFLAMM, V10, DOI 10.1186/1742-2094-10-106
- Zuccato C, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0022966