Shifting concepts in rectal cancer management A Review of Contemporary Primary Rectal Cancer Treatment Strategies

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author KOSINSKI, Lauren
HABR-GAMA, Angelita FMUSP-HC
LUDWIG, Kirk
PEREZ, Rodrigo FMUSP-HC
dc.date.issued 2012
dc.identifier.citation CA-A CANCER JOURNAL FOR CLINICIANS, v.62, n.3, p.173-202, 2012
dc.identifier.issn 0007-9235
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/1324
dc.description.abstract The management of rectal cancer has transformed over the last 3 decades and continues to evolve. Some of these changes parallel progress made with other cancers: refinement of surgical technique to improve organ preservation, selective use of neoadjuvant (and adjuvant) therapy, and emergence of criteria suggesting a role for individually tailored therapy. Other changes are driven by fairly unique issues including functional considerations, rectal anatomic features, and surgical technical issues. Further complexity is due to the variety of staging modalities (each with its own limitations), neoadjuvant treatment alternatives, and competing strategies for sequencing multimodal treatment even for nonmetastatic disease. Importantly, observations of tumor response made in the era of neoadjuvant therapy are reshaping some traditionally held concepts about tumor behavior. Frameworks for prioritizing and integrating complex data can help to formulate treatment plans for patients. CA Cancer J Clin 2012;. (C) 2012 American Cancer Society.
dc.language.iso eng
dc.publisher WILEY-BLACKWELL
dc.relation.ispartof Ca-A Cancer Journal for Clinicians
dc.rights restrictedAccess
dc.subject.other total mesorectal excision; transanal endoscopic microsurgery; positron-emission-tomography; low anterior resection; laparoscopic colorectal surgery; pathological complete response; randomized multicenter trial; lymph-node status; postoperative adjuvant chemotherapy; preoperative chemoradiation therapy
dc.title Shifting concepts in rectal cancer management A Review of Contemporary Primary Rectal Cancer Treatment Strategies
dc.type article
dc.rights.holder Copyright WILEY-BLACKWELL
dc.identifier.doi 10.3322/caac.21138
dc.identifier.pmid 22488575
dc.type.category review
dc.type.version publishedVersion
hcfmusp.author PEREZ, Rodrigo:HC:ICHC
hcfmusp.author HABR-GAMA, Angelita:FM:MGT
hcfmusp.author.external · KOSINSKI, Lauren:Med Coll Wisconsin, Dept Surg, Div Colorectal Surg, Milwaukee, WI 53226 USA
· LUDWIG, Kirk:Med Coll Wisconsin, Dept Surg, Div Colorectal Surg, Milwaukee, WI 53226 USA
hcfmusp.origem.id WOS:000303665400004
hcfmusp.origem.id 2-s2.0-84860796157
hcfmusp.publisher.city HOBOKEN
hcfmusp.publisher.country USA
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hcfmusp.affiliation.country Brasil
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