Th17 and regulatory T cells contribute to the in situ immune response in skin lesions of Jorge Lobo's disease
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Citações na Scopus
7
Tipo de produção
article
Data de publicação
2016
Editora
OXFORD UNIV PRESS
Indexadores
Título da Revista
ISSN da Revista
Título do Volume
Autores
BARBOZA, Tania Cristina
BRITO, Arival Cardoso de
XAVIER, Marilia Brasil
OLIVEIRA, Clivia Maria Moraes de
UNGER, Deborah Aben Athar
QUARESMA, Juarez Antonio Simoes
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
MEDICAL MYCOLOGY, v.54, n.1, p.23-28, 2016
Resumo
Jorge Lobo's disease (JLD) is a chronic granulomatous mycosis described in various Latin American countries. The main objective of the present study was to investigate the possible role of Th17 and Foxp3+ Treg cells in the pathogenesis of Jorge Lobo's disease. Human skin biopsies were submitted to an immunohistochemistry protocol to detect Foxp3, interleukin (IL)-1beta, CD25, IL-6, IL-17, and IL-23. The epidermis presented acanthosis, hyperkeratosis, and frequent presence of fungi. The dermis presented inflammatory infiltrate comprising macrophages, lymphocytes, epithelioid and multinucleated cells, and an intense number of fungi. Foxp3+ Treg cells and IL-17+ cells were visualized in lymphocytes in the inflammatory infiltrate. IL-1, IL-2R (CD25), IL-6, and IL-23 were visualized in the dermis, intermingled with fungal cells, permeating or participating of the granuloma. Following IL-17, the most prominent cytokine was IL-6. IL-23 and cells expressing CD25 were present in fewer number. The comparative analysis between IL-17 and Foxp3 demonstrated a statistically significant increased number of IL-17+ cells. Th17 cells play a role in the immune response of JLD. IL-1beta and IL-6 added to the previously described increased number of TGF-beta would stimulate such pattern of response. Th17 cells could be present as an effort to modulate the local immune response; however, high levels of a Th17 profile could overcome the role of Treg cells. The unbalance between Treg/Th17 cells seems to corroborate with the less effective immune response against the fungus.
Palavras-chave
Jorge Lobo's Disease, immune response, Th17 cells, regulatory T cells
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