Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/13597
Title: | Time trend analysis of cervical high-risk human papillomavirus (HPV) in HIV-infected women in an urban cohort from Rio de Janeiro, Brazil: the rise of non-16/18 HPV |
Authors: | CAMBOU, Mary C.; LEVI, Jose Eduardo; LAKE, Jordan E.; ANDRADE, Angela de; JALIL, Emilia M.; RUSSOMANO, Fabio; DERRICO, Monica; VELOSO, Valdilea G.; FRIEDMAN, Ruth K.; LUZ, Paula M.; GRINSZTEJN, Beatriz |
Citation: | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v.41, p.17-20, 2015 |
Abstract: | Objectives: HIV-infected women are at increased risk of human papillomavirus (HPV) infection. Time trends in annual prevalences of cervical high-risk human papillomavirus (HR-HPV) genotypes among a non-vaccinated, HIV-infected female cohort in urban Brazil were assessed for the period 2006-2012. Methods: Cervical specimens were collected for HPV genotyping yearly between January 2006 and December 2012 in a cross-sectional analysis of participants aged >= 18 years enrolled in the Women's HIV Cohort at Fiocruz in Rio de Janeiro, Brazil. Age-adjusted generalized estimating equation models with an exchangeable matrix were used to estimate odds ratios (OR) and 95% confidence intervals (CI) for annual HPV positivity (reference year: 2006). Results: Among the 590 participants, the median age across all study years ranged from 35.5 to 40.0 years. The prevalence of any HR-HPV was >= 53% every year; prevalences of HR-HPV 16, 58, 59, and 68 were >= 24% in at least 1 year. The odds of HPV 16 and 68 decreased in 2012. HPV 58 prevalence followed a U-shape, beginning and ending at >20%. HPV 59 prevalence followed a linear trend, with increased odds in 2012 (OR 16.0, 95% CI 3.8-67.3; Bonferroni-adjusted p-value <0.01). Conclusions: The prevalences of HR-HPV 58, 59, and 68 were high in this cohort. Given current HR-HPV vaccine coverage and availability, further investigations are needed to optimize vaccine recommendations for this population. (C) 2015 The Authors. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/52 Artigos e Materiais de Revistas Científicas - ODS/03 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_CAMBOU_Time_trend_analysis_of_cervical_highrisk_human_papillomavirus_2015.PDF | publishedVersion (English) | 278.22 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.