Ischemic preconditioning modifies mortality and inflammatory response
Carregando...
Citações na Scopus
7
Tipo de produção
article
Data de publicação
2016
Editora
ACTA CIRURGICA BRASILEIRA
Indexadores
Título da Revista
ISSN da Revista
Título do Volume
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
ACTA CIRURGICA BRASILEIRA, v.31, n.1, p.1-7, 2016
Resumo
PURPOSE: To evaluate the effect of ischemic preconditioning on mortality, inflammatory mediators and oxidative stress after intestinal ischemia and reperfusion. METHODS: Male Wistar rats were allocated according to the period of ischemia with or without ischemic preconditioning which consist on clamping the superior mesenteric artery for 10 minutes followed by reperfusion for 10 minutes before the sustained ischemia period. Mortality was assessed in Phase 1 study, and the CINC-1, CINC-2 and MDA levels in the lungs were analyzed in Phase 2. RESULTS: Mortality was lower in the ischemic preconditioning group subjected to 90 minutes of ischemia compared to the group without ischemic preconditioning (I-90: 50% and IPC-90: 15%, p=0.018), and it was lower in the ischemic preconditioning group as a whole compared to the groups without ischemic preconditioning (IPC-14% and I=30%, p=0.006). Lower levels of MDA, CINC-1, and CINC-2 were observed in the animals that were subjected to ischemic preconditioning compared to the animals that were not (MDA: I-45=1.23 nmol/mg protein, and IPC-45=0.62 nmol/mg protein, p=0.0333; CINC-1: I-45=0.82 ng/mL and IPC-45=0.67 ng/mL, p=0.041; CINC-2: I-45=0.52 ng/mL and IPC-45=0.35 ng/mL, p=0.032). CONCLUSION: Ischemic preconditioning reduces mortality, inflammatory process and oxidative stress in rats subjected to intestinal ischemia and reperfusion.
Palavras-chave
Ischemic Preconditioning, Reperfusion, Mortality, Oxidative Stress, Rats
Referências
- Wang SF, 2003, WORLD J GASTROENTERO, V9, P1866
- Grotto D, 2007, J PHARMACEUT BIOMED, V43, P619, DOI 10.1016/j.jpba.2006.07.030
- Tsuboi H, 2007, AM J PHYSIOL-GASTR L, V292, pG678, DOI 10.1152/ajpgi.00361.2006
- Sola A, 2004, APOPTOSIS, V9, P353, DOI 10.1023/B:APPT.0000025812.45382.4d
- McCallion K, 2000, SHOCK, V14, P429, DOI 10.1097/00024382-200014040-00002
- KOIKE K, 1992, J SURG RES, V52, P656
- Coelho AMM, 2011, J GASTROINTEST SURG, V15, P1679, DOI 10.1007/s11605-011-1648-x
- MURRY CE, 1986, CIRCULATION, V74, P1124
- Figueira ERR, 2010, SURGERY, V147, P415, DOI 10.1016/j.surg.2009.10.018
- Tamion F, 2007, AM J PHYSIOL-GASTR L, V293, pG1308, DOI 10.1152/ajpgi.00154.2007
- Huang YC, 2009, TRANSPL IMMUNOL, V20, P127, DOI 10.1016/j.trim.2008.08.002
- Sola A, 2000, TRANSPLANTATION, V69, P767
- Hotter G, 1996, BIOCHEM BIOPH RES CO, V222, P27, DOI 10.1006/bbrc.1996.0692
- Kozar RA, 2004, J SURG RES, V116, P145, DOI 10.1016/S0022-4804(03)00301-9
- Jacome DT, 2009, TRANSPL P, V41, P827, DOI 10.1016/j.transproceed.2009.01.071
- Ito K, 2003, SHOCK, V19, P462, DOI 10.1097/01.shk.0000055240.25446.16
- Aksoyek S, 2002, SHOCK, V18, P476
- Wu B, 2004, AM J PHYSIOL-GASTR L, V286, pG580, DOI 10.1152/ajpgi.00335.2003
- Shibata F, 1996, CYTOKINE, V8, P222, DOI 10.1006/cyto.1996.0031
- Avgerinos ED, 2010, J SURG RES, V160, P294, DOI 10.1016/j.jss.2008.12.017
- Rupani B, 2007, SURGERY, V141, P481, DOI 10.1016/j.surg.2006.10.008
- Moraes LB, 2008, J TRAUMA, V64, P1196, DOI 10.1097/TA.0b013e31816c5ca6
- Mallick IH, 2004, DIGEST DIS SCI, V49, P1359, DOI 10.1023/B:DDAS.0000042232.98927.91
- Sola A, 1999, TRANSPLANTATION, V67, P1446, DOI 10.1097/00007890-199906150-00010
- Mallick IH, 2010, AM J SURG, V199, P223, DOI 10.1016/j.amjsurg.2009.01.011
- Korth U, 2003, RESUSCITATION, V58, P209, DOI 10.1016/S0300-9572(03)00119-9
- Tamion F, 2002, AM J PHYSIOL-GASTR L, V283, pG408, DOI 10.1152/ajpgi.00348.2001
- Castro e Silva Jr O, 2002, ACTA CIR BRAS, V17, P96, DOI 10.1590/S0102-86502002000900020
- Kubes P, 2002, AM J PHYSIOL-GASTR L, V283, P139, DOI [10.1152/ajpgi00058.2002, DOI 10.1152/AJPGI00058.2002]
- Neves JS, 2011, ACTA CIR BRAS, V26, P496
- Parks DA, 1986, AM J PHYSIOL, V250, P749
- Tomanari G. Y., 2003, REV BRAS TER COMPORT, V5, P57
- Zitta K, 2012, MOL MED, V1, P29