Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/1379
Title: | Botulinum Neurotoxin Type A for the Treatment of Benign Prostatic Hyperplasia: Randomized Study Comparing Two Doses |
Authors: | ARNOUK, Rene; BELLUCCI, Carlos Henrique Suzuki; STULL, Roberto Benatuil; BESSA JUNIOR, Jose de; MALAVE, Cesar Augusto; GOMES, Cristiano Mendes |
Citation: | SCIENTIFIC WORLD JOURNAL, article ID 463574, 6p, 2012 |
Abstract: | Purpose. To assess the efficacy and safety of intraprostatic injection of two botulinum neurotoxin type A (BoNT-A) doses for the treatment of benign prostatic hyperplasia (BPH). Materials and Methods. Men with symptomatic BPH who failed medical treatment were randomized to receive 100 U or 200 U of BoNT-A into the prostate. The International Prostatic Symptom Score (IPSS), maximum flow rate (Q(max)), post-void residual volume (PVR), PSA levels and prostate volume before injection and after 3 and 6 months were evaluated. Adverse events were compared between the groups. Results. Thirty four patients were evaluated, including 17 in the BoNT-A 100 U group and 17 in the BoNT-A 200 U group. Baseline characteristics were similar in both groups. Both doses produced significant improvements in IPSS, Q(max) and PVR after 3 and 6 months and both doses promoted comparable effects. Prostate volume was affected by 200 U BoNT-A injection only after 6 months of treatment. PSA levels were significantly affected in the 100 U group only after 6 months of treatment. In the 200 U group, PSA levels were significantly decreased after 3 and 6 months. The complication rate was similar in both groups. Conclusions. Efficacy and safety of both BoNT-A doses are similar for BPH treatment in the short term followup. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/IOT Artigos e Materiais de Revistas Científicas - LIM/55 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_GOMES_Botulinum_Neurotoxin_Type_A_for_the_Treatment_of_2012.PDF | publishedVersion (English) | 1.63 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.