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Title: | Detection of Cerebral Vasculopathy by Transcranial Doppler in Children With Neurofibromatosis Type 1 |
Authors: | PASCHOAL, Joelma Karin Sagica Fernandes; PASCHOAL JR., Fernando Mendes; LIMA, Fernanda Teresa de; PINHO, Ricardo Silva; VILANOVA, Luiz Celso Pereira; BOR-SENG-SHU, Edson; MASRUHA, Marcelo Rodrigues |
Citation: | JOURNAL OF CHILD NEUROLOGY, v.31, n.3, p.351-356, 2016 |
Abstract: | Neurofibromatosis type 1 is characterized by nerve sheath neurofibromas associated with a number of additional clinical features, including cerebrovascular disease. The aim of this study was to use transcranial Doppler as a screening method for identifying cerebral vasculopathy in children with neurofibromatosis type 1. Forty children with neurofibromatosis type 1, aged 5 to 18 years old, were examined by transcranial Doppler. Patients presenting with hemodynamic features of arterial stenosis/occlusion on transcranial Doppler underwent magnetic resonance angiography to confirm the findings. Magnetic resonance angiography was performed on 4 children who exhibited a transcranial Doppler hemodynamic pattern indicative of cerebral vasculopathy. Among these cases, 2 presented internal carotid artery stenosis/occlusion, 1 had bilateral middle cerebral artery stenosis, and 1 presented a normal magnetic resonance angiography result. Transcranial Doppler can be used routinely in the investigation of cerebrovascular disease in neurofibromatosis type 1 patients, where magnetic resonance angiography can be subsequently applied to confirm the diagnosis, further contributing to the prevention of cerebrovascular events. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/26 Artigos e Materiais de Revistas Científicas - ODS/03 |
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