Beneficial Effects of Physical Exercise on Functional Capacity and Skeletal Muscle Oxidative Stress in Rats with Aortic Stenosis-Induced Heart Failure

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art_GOMES_Beneficial_Effects_of_Physical_Exercise_on_Functional_Capacity_2016.PDF (1.62 MB)
Citações na Scopus
44
Tipo de produção
article
Data de publicação
2016
Editora
HINDAWI PUBLISHING CORP
DOI
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Scopus
Web of Science
PubMed
Título da Revista
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Título do Volume
Autores
GOMES, Mariana Janini
MARTINEZ, Paula Felippe
CAMPOS, Dijon Henrique Salome
PAGAN, Luana Urbano
BONOMO, Camila
LIMA, Aline Regina Ruiz
DAMATTO, Ricardo Luiz
CEZAR, Marcelo D. M.
DAMATTO, Felipe Cezar
ROSA, Camila Moreno
Autor de Grupo de pesquisa
Editores
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Organizadores
Citação
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, article ID 8695716, 12p, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective. We evaluated the influence of exercise on functional capacity, cardiac remodeling, and skeletal muscle oxidative stress, MAPK, and NF-kappa B pathway in rats with aortic stenosis-(AS-) induced heart failure (HF). Methods and Results. Eighteen weeks after AS induction, rats were assigned into sedentary control (C-Sed), exercised control (C-Ex), sedentary AS (AS-Sed), and exercised AS (AS-Ex) groups. Exercise was performed on treadmill for eight weeks. Statistical analyses were performed with Goodman and ANOVA or Mann-Whitney. HF features frequency and mortality did not differ between AS groups. Exercise improved functional capacity, assessed by maximal exercise test on treadmill, without changing echocardiographic parameters. Soleus cross-sectional areas did not differ between groups. Lipid hydroperoxide concentration was higher in AS-Sed than C-Sed and AS-Ex. Activity of antioxidant enzymes superoxide dismutase and glutathione peroxidase was changed in AS-Sed and restored in AS-Ex. NADPH oxidase activity and gene expression of its subunits did not differ between AS groups. Total ROS generation was lower in AS-Ex than C-Ex. Exercise modulated MAPK in AS-Ex and did not change NF-kappa B pathway proteins. Conclusion. Exercise improves functional capacity in rats with AS-induced HF regardless of echocardiographic parameter changes. In soleus, exercise reduces oxidative stress, preserves antioxidant enzyme activity, and modulates MAPK expression.
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URI
https://observatorio.fm.usp.br/handle/OPI/14045
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Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/19