Assessment of Background Parenchymal Enhancement and Lesion Kinetics in Breast MRI of BRCA 1/2 Mutation Carriers Compared to Matched Controls Using Quantitative Kinetic Analysis

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art_LEWIN_Assessment_of_Background_Parenchymal_Enhancement_and_Lesion_Kinetics_2016.PDF (1.42 MB)
Citações na Scopus
10
Tipo de produção
article
Data de publicação
2016
Editora
ELSEVIER SCIENCE INC
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
LEWIN, Alana A.
KIM, Sungheon Gene
BABB, James S.
MELSAETHER, Amy N.
MCKELLOP, Jason
MOCCALDI, Melanie
MOY, Linda
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
ACADEMIC RADIOLOGY, v.23, n.3, p.358-367, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Rationale and Objectives: To investigate whether quantitative kinetic analysis of lesions and background parenchyma in breast magnetic resonance imaging can elucidate differences between BRCA carriers and sporadic controls with high risk for breast cancer. Materials and Methods: Fifty-nine BRCA and 59 control cases (49 benign, 10 malignant) were examined in this study. Principal component analysis was applied for quantitative analysis of dynamic signal in background parenchyma (B) and lesion (L) in terms of initial enhancement ratio (IER) and delayed enhancement ratio (DER). Results: Control B-IER, B-DER, L-IER, and L-DER were higher than BRCA cases in all women and in women with benign lesions; statistically significant differences in B-IER and B-DER (all women: P = 0.02 and P = 0.02, respectively; benign only: P = 0.005 and P = 0.005, respectively). In the control cohort, B-IER and B-DER were higher in the premenopausal women than in the postmenopausal women (P = 0.013 and 0.003, respectively), but not in the BRCA cohort; this led to significant differences in B-IER and B-DER between the control and the BRCA groups in the premenopausal women (P = 0.01 and 0.01, respectively) but not in the postmenopausal women. Conclusion: Results suggest possible differences in the vascular properties of background parenchyma between BRCA carriers and noncarriers and its association with menopausal status.
Palavras-chave
BRCA 1/2 mutation carrier, background parenchymal enhancement (BPE), principal component analysis (PCA), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)
URI
https://observatorio.fm.usp.br/handle/OPI/14063
Referências
  1. Ponder BAJ, 2000, BRIT J CANCER, V83, P1301
  2. Kuhl CK, 1997, RADIOLOGY, V203, P137
  3. Scaranelo AM, 2013, RADIOLOGY, V267, P692, DOI 10.1148/radiol.13120121
  4. Whittemore AS, 2004, CANCER EPIDEM BIOMAR, V13, P2078
  5. DeMartini WB, 2012, AM J ROENTGENOL, V198, pW373, DOI 10.2214/AJR.10.6272
  6. Kajihara M, 2013, MAGN RESON MED SCI, V12, P39, DOI 10.2463/mrms.2012-0022
  7. Amarosa AR, 2013, RADIOLOGY, V268, P356, DOI 10.1148/radiol.13121101
  8. Weinstein S, 2014, RADIOGRAPHICS, V34, P247, DOI 10.1148/rg.341135172
  9. Mote PA, 2004, GENE CHROMOSOME CANC, V39, P236, DOI 10.1002/gcc.10321
  10. Hussain Z, 1999, BRIT J RADIOL, V72, P236
  11. Tofts PS, 1999, J MAGN RESON IMAGING, V10, P223, DOI 10.1002/(SICI)1522-2586(199909)10:3<223::AID-JMRI2>3.0.CO;2-S
  12. Ko ES, 2011, ACTA RADIOL, V52, P256, DOI 10.1258/ar.2010.100187
  13. Eyal E, 2009, J MAGN RESON IMAGING, V30, P989, DOI 10.1002/jmri.21950
  14. Campeau PM, 2008, HUM GENET, V124, P31, DOI 10.1007/s00439-008-0529-1
  15. Sardanelli F, 2011, INVEST RADIOL, V46, P94, DOI 10.1097/RLI.0b013e3181f3fcdf
  16. Smith RA, 2003, CA-CANCER J CLIN, V53, P141
  17. O'Donovan PJ, 2010, CARCINOGENESIS, V31, P961, DOI 10.1093/carcin/bgq069
  18. Delille JP, 2005, RADIOLOGY, V235, P36, DOI 10.1148/radiol.2351040012
  19. Kang SS, 2014, J MAGN RESON IMAGING, V39, P526, DOI 10.1002/jmri.24185
  20. King V, 2011, RADIOLOGY, V260, P50, DOI 10.1148/radiol.11102156
  21. Gilliland FD, 2000, J NATL CANCER I, V92, P743, DOI 10.1093/jnci/92.9.743
  22. King V, 2012, BREAST J, V18, P527, DOI 10.1111/tbj.12002
  23. Gutierrez RL, 2009, AM J ROENTGENOL, V193, P994, DOI 10.2214/AJR.08.1983
  24. Zakhartseva L. M., 2009, Experimental Oncology, V31, P174
  25. Morris EA, 2007, RADIOL CLIN N AM, V45, P863, DOI 10.1016/i.rcl.2007.07.002
  26. Bluemke DA, 2004, JAMA-J AM MED ASSOC, V292, P2735, DOI 10.1001/jama.292.22.2735
  27. Price ER, 2014, EUR RADIOL, V24, P162, DOI 10.1007/s00330-013-2993-9
  28. Mahoney MC, 2012, RADIOLOGY, V264, P51, DOI 10.1148/radiol.12110619
  29. Antoniou A, 2003, AM J HUM GENET, V72, P1117, DOI 10.1086/375033
  30. Kim SA, 2014, RADIOLOGY, V270, P699, DOI 10.1148/radiol.13130459
  31. King V, 2012, EUR RADIOL, V22, P2641, DOI 10.1007/s00330-012-2553-8
  32. Huang W, 2008, P NATL ACAD SCI USA, V105, P17943, DOI 10.1073/pnas.0711226105
  33. BI-RADS Committee, 2003, BREAST IM REP DAT SY
  34. Easton D F, 1999, Breast Cancer Res, V1, P14, DOI 10.1186/bcr6
  35. Gillman Jennifer, 2014, Womens Health (Lond Engl), V10, P609, DOI 10.2217/whe.14.61
  36. van Voss MRH, 2010, BMC CANCER, V10, DOI 10.1186/1471-2407-10-145
  37. Howlader N, 2013, SEER CANC STAT REV 1
  38. Obdeijn IM, 2014, BREAST CANCER RES TR, V144, P577, DOI 10.1007/s10549-014-2888-8

Coleções
Artigos e Materiais de Revistas Científicas - HC/InRad
Artigos e Materiais de Revistas Científicas - ODS/03