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https://observatorio.fm.usp.br/handle/OPI/14121
Title: | Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study |
Authors: | KEMP, Andrew H.; LOPEZ, Santiago Rodriguez; PASSOS, Valeria M. A.; BITTENCOURT, Marcio S.; DANTAS, Eduardo M.; MILL, Jose G.; RIBEIRO, Antonio L. P.; THAYER, Julian F.; BENSENOR, Isabela M.; LOTUFO, Paulo A. |
Citation: | BIOLOGICAL PSYCHOLOGY, v.117, p.216-224, 2016 |
Abstract: | Background: Research has linked high-frequency heart rate variability (HF-HRV) to cognitive function. The present study adopts a modern path modelling approach to understand potential causal pathways that may underpin this relationship. Methods: Here we examine the association between resting-state HF-HRV and executive function in a large sample of civil servants from Brazil (N = 8114) recruited for the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). HF-HRV was calculated from 10-min resting-state electrocardiograms. Executive function was assessed using the trail-making test (version B). Results and conclusions: Insulin resistance (a marker of type 2 diabetes mellitus) and carotid intima-media thickness (subclinical atherosclerosis) mediated the relationship between HRV and executive function in seriatim. A limitation of the present study is its cross-sectional design; therefore, conclusions must be confirmed in longitudinal study. Nevertheless, findings support that possibility that HRV provides a 'spark' that initiates a cascade of adverse downstream effects that subsequently leads to cognitive impairment. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCM Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - HU Artigos e Materiais de Revistas Científicas - LIM/20 Artigos e Materiais de Revistas Científicas - ODS/03 |
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