Validation of coronary computed tomography angiography scores for non-invasive assessment of atherosclerotic burden through a comparison with multivessel intravascular ultrasound

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dc.contributor Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.author CAVALCANTE, Rafael FMUSP-HC
BITTENCOURT, Marcio S. FMUSP-HC
PINHEIRO, Thais L.
FALCAO, Breno A. A. FMUSP-HC
MORAIS, Gustavo R.
SOARES, Paulo FMUSP-HC
MARIANI JR., Jose FMUSP-HC
RIBEIRO, Expedito FMUSP-HC
KALIL-FILHO, Roberto FMUSP-HC
ROCHITTE, Carlos E. FMUSP-HC
LEMOS, Pedro A. FMUSP-HC
dc.date.issued 2016
dc.identifier.citation ATHEROSCLEROSIS, v.247, p.21-27, 2016
dc.identifier.issn 0021-9150
dc.identifier.uri http://observatorio.fm.usp.br/handle/OPI/14178
dc.description.abstract Aims: While the atherosclerotic plaque volume can be manually quantified in coronary computed tomography angiography (CTA) it is impractical for clinical routine use. Several anatomical scores have been developed as surrogates for overall atherosclerotic burden in coronary CTA and even proven to be highly predictive for future adverse events. However, they have not been validated against the gold standard for atherosclerotic burden, intra-vascular ultrasound (IVUS). In the present study we have compared several coronary CTA scores with the coronary IVUS. Methods and results: A total of 62 patients with diagnosed coronary disease scheduled for percutaneous intervention were prospectively enrolled. For all patients, coronary CTA and multivessel IVUS were obtained. Calcium score and 6 previously reported scores were calculated from coronary CTA imaging and compared to average IVUS-derived percent atheroma volume (PAV). On average, 3.8 +/- 0.7 vessels, comprising 123.8 +/- 31.3 mm in length, were imaged with IVUS per patient. All but one previously described scoring systems showed a significant association with IVUS-derived PAV. Among them, the SSS score demonstrated the strongest correlation with IVUS-PAV (r = 0.61, p < 0.001) and the greatest area under the ROC curve (C-statistic = 0.87), to predict a high PAV. Conclusions: Most frequently used coronary CTA scores have a good correlation with global coronary atherosclerotic burden measured by multivessel IVUS derived atheroma volume. Among them, the SSS score shows the best performance being a good non-invasive alternative to IVUS for global coronary atherosclerotic burden assessment.
dc.description.sponsorship · National Council for Scientific and Technological Development (CNPq) - Brazil
· State of Sao Paulo Research Foundation (FAPESP)
dc.language.iso eng
dc.publisher ELSEVIER IRELAND LTD
dc.relation.ispartof Atherosclerosis
dc.rights restrictedAccess
dc.subject Atherosclerosis; Coronary disease; Computed tomography; Intravascular ultrasound
dc.subject.other randomized controlled-trial; artery-disease; cardiovascular events; clinical-outcomes; prognostic value; statin therapy; progression; regression; plaque; ct
dc.title Validation of coronary computed tomography angiography scores for non-invasive assessment of atherosclerotic burden through a comparison with multivessel intravascular ultrasound
dc.type article
dc.rights.holder Copyright ELSEVIER IRELAND LTD
dc.description.group LIM/11
dc.identifier.doi 10.1016/j.atherosclerosis.2016.01.040
dc.identifier.pmid 26854972
dc.type.category original article
dc.type.version publishedVersion
hcfmusp.author CAVALCANTE, Rafael:HC:INCOR
hcfmusp.author BITTENCOURT, Marcio S.:HU:SCPACEX-62
hcfmusp.author FALCAO, Breno A. A.:HC:INCOR
hcfmusp.author SOARES, Paulo:HC:INCOR
hcfmusp.author MARIANI JR., Jose:HC:INCOR
hcfmusp.author RIBEIRO, Expedito:HC:INCOR
hcfmusp.author KALIL-FILHO, Roberto:FM:MCP
hcfmusp.author ROCHITTE, Carlos E.:HC:INCOR
hcfmusp.author LEMOS, Pedro A.:HC:INCOR
hcfmusp.author.external · PINHEIRO, Thais L.:Univ Sao Paulo, Sch Med, Heart Inst InCor, Dept Intervent Cardiol, Sao Paulo, Brazil
· MORAIS, Gustavo R.:Univ Sao Paulo, Sch Med, Heart Inst InCor, Dept Intervent Cardiol, Sao Paulo, Brazil
hcfmusp.origem.id 2-s2.0-84969405467
hcfmusp.origem.id WOS:000372718900003
hcfmusp.publisher.city CLARE
hcfmusp.publisher.country IRELAND
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dc.description.index MEDLINE
dc.identifier.eissn 1879-1484
hcfmusp.citation.scopus 3
hcfmusp.citation.wos 3
hcfmusp.affiliation.country Brasil


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